What is Pirfenidone?

Category: Prescription Drugs

Most popular types: Esbriet Pirfenex IPF Phase III ASCEND (pirfenidone) Show all

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Pirfenidone is an oral medication used for the treatment of idiopathic pulmonary fibrosis (IPF). The exact way this drug works is not yet fully understood, but it is believed to help fight the fibrosis and inflammation that lead to the progression of IPF.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Idiopathic pulmonary fibrosis 326 229
Asbestosis 1 0
Feels like i am suffocating 1 0
Support immune health 1 0
Swelling in lower extremities 1 2

Show all 6 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 41
Moderate 51
Mild 94
None 47

Commonly reported side effects and conditions associated with Pirfenidone

Side effect Patients Percentage
Decreased appetite 120
Nausea 101
Indigestion 99
Headaches 74
Abdominal pain 73
Rashes (redness, swelling) 64

Show all 66 reported side effects

Dosages

Based on patients currently taking Pirfenidone

Dosage Patients Percentage
801 mg three times daily 8
267 mg three times daily 3
2403 mg daily 3
267 mg twice daily 1
534 mg three times daily 1

Why patients stopped taking Pirfenidone

Multiple reasons could be selected

Reason Patients Percentage
Side effects too severe 29
Doctor's advice 15
Did not seem to work 8
Other 4
Course of treatment ended 1
See all 41 patients who've stopped taking Pirfenidone

Duration

Currently taking Pirfenidone

Duration Patients Percentage
6 months - 1 year 2
1 - 2 years 2
2 - 5 years 9
5 - 10 years 3

Stopped taking Pirfenidone

Duration Patients Percentage
Less than 1 month 5
1 - 6 months 13
6 months - 1 year 10
1 - 2 years 11
2 - 5 years 2
Adherence
Adherence Evaluations Percentage
Always 176
Usually 34
Sometimes 5
Never taken as prescribed 18
Burden
Burden Evaluations Percentage
Very hard to take 19
Somewhat hard to take 57
A little hard to take 60
Not at all hard to take 97
Cost per month
Cost per month Evaluations Percentage
$200+ 29
$100-199 4
$50-99 3
$25-49 10
< $25 95
Not specified 92

What people switch to and from

Patients started taking Pirfenidone after stopping:

Treatment Patients Percentage
Nintedanib (Ofev) 12
Acetylcysteine (Efetil) 2
Pirfenidone (Esbriet) 2
ALS Phase 2 Study Creatine/Tamoxifen Clinical Trial 1
Azathioprine (Imuran) 1

Show all 9 treatments patients report switching from

Patients stopped taking Pirfenidone and switched to:

Treatment Patients Percentage
Nintedanib (Ofev) 21
Oxygen therapy 2
Pirfenidone (Esbriet) 2
Vitamin B (Stress Vitamin B) 1
Vitamin B Complex (High Potency Vitamin B Complex) 1
Last updated:

2 patient evaluations for Pirfenidone

Dec 15, 2017 (Started Feb 06, 2016)

  • Effectiveness
    None (for idiopathic pulmonary fibrosis)
  • Side effects
    Mild (cough, shortness of breath with exertion, constant hunger)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 267 mg Three times daily
Cost: < $25 monthly

May 23, 2017 (Started Feb 06, 2016)

  • Effectiveness
    Can't tell (for idiopathic pulmonary fibrosis)
  • Side effects
    Mild (cough, shortness of breath with exertion, constant hunger)
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 267 mg Three times daily
Cost: < $25 monthly

Feb 3, 2017 (Started Feb 06, 2016)

  • Effectiveness
    Can't tell (for idiopathic pulmonary fibrosis)
  • Side effects
    Mild (cough, shortness of breath with exertion, constant hunger)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 267 mg Three times daily
Cost: < $25 monthly

Jan 28, 2017 (Started Feb 06, 2016)

  • Effectiveness
    Can't tell (for idiopathic pulmonary fibrosis)
  • Side effects
    Mild (cough, shortness of breath with exertion, constant hunger)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 267 mg Three times daily
Cost: < $25 monthly

Sep 29, 2016 (Started Feb 06, 2016)

  • Effectiveness
    Can't tell (for idiopathic pulmonary fibrosis)
  • Side effects
    Mild (cough, shortness of breath with exertion, constant hunger)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 267 mg Three times daily
Advice & Tips: Set my fitness tracker to remind me to take pills. Usually half a bananna is enough food for me to take the pills in the morning
Cost: < $25 monthly

Jul 24, 2016 (Started Feb 06, 2016)

  • Effectiveness
    Can't tell (for idiopathic pulmonary fibrosis)
  • Side effects
    Moderate (cough, shortness of breath with exertion, constant hunger)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 267 mg Three times daily
Cost: < $25 monthly

Feb 20, 2016 (Started Feb 06, 2016)

  • Effectiveness
    Can't tell (for idiopathic pulmonary fibrosis)
  • Side effects
    Mild (cough, shortness of breath with exertion, constant hunger)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 267 mg Three times daily
Advice & Tips: I sent my fitness tracker to remind to take
Cost: < $25 monthly

  • 1 helpful mark

May 27, 2015 (Started Nov 11, 2012)

  • Effectiveness
    Moderate (for idiopathic pulmonary fibrosis)
  • Side effects
    Moderate (exhaustion)
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 4 mg Daily
Advice & Tips: Now I take Pirfenidone 200 mg x10 tablets a day as my fibrosis spread to lower part of lung after 10 years . It started from lower part of left lung .
Cost: $200+ monthly

Oct 13, 2014 (Started Nov 11, 2012)

  • Effectiveness
    Major (for idiopathic pulmonary fibrosis)
  • Side effects
    Mild (exhaustion)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 4 mg Daily
Cost: $200+ monthly

Nov 26, 2013 (Started Nov 11, 2012)

  • Effectiveness
    Major (for idiopathic pulmonary fibrosis)
  • Side effects
    Moderate (exhaustion)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4 mg Daily
Advice & Tips: I started with 2 tablets a day . I had headache after 10 days . I stopped for 4 days I started again. After 3 week I started 4 tablets a day . I started feeling of tiredness . I had headache after 15 days . I stopped for 3 days I started again 4 tablets . I reached level of 8 tablets with in 3 months . I do checking of liver / renal / lipid profile and RBC count every quarter . All parameters of above test gone up high in last 8 months in comparatively before start of pirfenidone . As per my medical doctor they are in safe limits.my oxygen level after 6 mts walk improved in 9 months .my Fvc is now 74 percent which was 57 percent in year 2010 .i take nutrients like nano curcumin / dry ginger / basil extract tablets and alpha lipolic acid tablets .i take 2 tablets of rabeperazole as anti acid for reflux
Cost: $200+ monthly

  • 4 helpful marks
Last updated:
Showing 2 of 2 patient evaluations for Pirfenidone