What is Mitoxantrone?

Category: Prescription Drugs

Most popular types: Novantrone

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See also: FCMR protocol

Mitoxantrone is an antineoplastic agent used in the treatment of acute nonlymphocytic leukemia, prostate cancer, secondary progressive or relapsing-remitting MS. It may also be used for certain lymphomas, certain adult and pediatric leukemias, myelodysplastic syndrome, breast cancer and sarcoma.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple sclerosis 254 76
Improve mobility 3 5
Weakness in leg(s) 3 1
Neuromyelitis optica 2 0
General health 1 0

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 17
Moderate 23
Mild 24
None 17

Commonly reported side effects and conditions associated with Mitoxantrone

Side effect Patients Percentage
Nausea 15
Tiredness 13
Hair loss 11
Headaches 6
Pain 6
Generalized weakness (asthenia) 5

Show all 29 reported side effects

Dosages

Based on patients currently taking Mitoxantrone

Dosage Patients Percentage
2 mg every 3 months 1
2 mg monthly 1
20 mg every 3 months 1
1000 mg every 6 months 1
2 mg as needed 1

Why patients stopped taking Mitoxantrone

Multiple reasons could be selected

Reason Patients Percentage
Course of treatment ended 100
Doctor's advice 76
Did not seem to work 57
Side effects too severe 55
Other 20
Personal research 6
Expense 3
Change in health plan coverage 1
See all 235 patients who've stopped taking Mitoxantrone

Duration

Currently taking Mitoxantrone

Duration Patients Percentage
6 months - 1 year 1
1 - 2 years 1
5 - 10 years 1
10 years or more 3

Stopped taking Mitoxantrone

Duration Patients Percentage
Less than 1 month 30
1 - 6 months 46
6 months - 1 year 52
1 - 2 years 52
2 - 5 years 46
5 - 10 years 5
10 years or more 4
Adherence
Adherence Evaluations Percentage
Always 72
Usually 5
Sometimes 0
Never taken as prescribed 4
Burden
Burden Evaluations Percentage
Very hard to take 10
Somewhat hard to take 20
A little hard to take 20
Not at all hard to take 31
Cost per month
Cost per month Evaluations Percentage
$200+ 3
$100-199 2
$50-99 0
$25-49 2
< $25 24
Not specified 50

What people switch to and from

Patients started taking Mitoxantrone after stopping:

Treatment Patients Percentage
Interferon beta-1a IM Injection (Avonex) 2
Natalizumab (Tysabri) 2
Glatiramer acetate (Copaxone) 1
Interferon beta-1a SubQ injection (Rebif) 1
Interferon beta-1b SubQ Injection (Betaseron) 1

Show all 6 treatments patients report switching from

Patients stopped taking Mitoxantrone and switched to:

Treatment Patients Percentage
Natalizumab (Tysabri) 3
Glatiramer acetate (Copaxone) 2
Fingolimod (Gilenya) 1
Naltrexone (Low Dose Naltrexone (LDN)) 1
Stem Cell Transplant (Autologous Stem Cell Transplant) 1
Last updated:

20 patient evaluations for Mitoxantrone

Mar 15, 2012 (Started Jan 05, 2011)

  • Effectiveness
    Can't tell (for multiple sclerosis)
  • Side effects
    Severe (It affected my heart, heart problems)
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Advice & Tips: Just make sure your Dr does regular blood test and Echocardiograms to keep a close watch on you hearts function.
Cost: < $25 monthly

  • 0 helpful marks

Jun 16, 2011 (Started Feb 05, 2011)

  • Effectiveness
    Slight (for multiple sclerosis)
  • Side effects
    Moderate (fatigue)
  • Adherence
    Always
  • Burden
    Very hard to take
Dosage: 20 mg Every 3 months
Advice & Tips: When you start this treatment program. You have a sonogram done on your heart. blood test for a baseline. Then you start treatment after treatment a week later a blood test then a two weeks. Then before your next round of treatment blood test and another heart sonogram.
Cost: < $25 monthly
Side effects: fatigue

  • 1 helpful mark

May 18, 2011 (Started Apr 04, 2008)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    Severe (nausea)
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 5 mg Every 3 months
Advice & Tips: This was a miracle drug for me. It is IV chemotherapy treatment for last ditch effort in treating MS. It turned my world around to where I felt like a functioning human again. It virtually stopped my exacerbations and I was able to walk on my own for the first time in seven years. The side effects were terrible for about two weeks after treatment. Vomiting and nausea, with lots of weakness and I lost my hair. The sad thing is that you can only take so many treatments in a lifetime. Now that mine are over I am going downhi again.
Side effects: nausea

  • 2 helpful marks
Last updated:
Showing 3 of 20 patient evaluations for Mitoxantrone