What is Methylfolate (l-methylfolate)?

Category: Supplements

Most popular types: Deplin Metanx

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Methylfolate, or l-methylfolate, is the active form of folate in the body. Folate is necessary for formation of numerous coenzymes in many metabolic systems.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Increase effect of another treatment 59 27
Major depressive disorder 31 29
Depressed mood 28 10
Methylenetetrahydrofolate reductase deficiency 17 9
Fatigue 8 3
Myalgic encephalomyelitis/chronic fatigue syndrome 4 7

Show all 54 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 3
Moderate 3
Mild 8
None 98

Commonly reported side effects and conditions associated with Methylfolate (l-methylfolate)

Side effect Patients Percentage
Dizziness 1
Dysphoric mania 1
Food allergy 1
Insomnia 1
Irritability 1
None 1

Show all 10 reported side effects

Dosages

Based on patients currently taking Methylfolate (l-methylfolate)

Dosage Patients Percentage
15 mg daily 10
7.5 mg daily 4
1 capsule(s) daily 1
1 mg daily 1
2 mg daily 1
2 other daily 1
5 mg daily 1
12 mg daily 1
1000 mg weekly 1
500 mcg daily 1

See all 13 dosages

Why patients stopped taking Methylfolate (l-methylfolate)

Multiple reasons could be selected

Reason Patients Percentage
Did not seem to work 26
Expense 15
Other 11
Doctor's advice 8
Course of treatment ended 5
Side effects too severe 4
Change in health plan coverage 2
See all 54 patients who've stopped taking Methylfolate (l-methylfolate)

Duration

Currently taking Methylfolate (l-methylfolate)

Duration Patients Percentage
1 - 6 months 4
1 - 2 years 7
2 - 5 years 7
5 - 10 years 7
10 years or more 1

Stopped taking Methylfolate (l-methylfolate)

Duration Patients Percentage
Less than 1 month 6
1 - 6 months 23
6 months - 1 year 7
1 - 2 years 10
2 - 5 years 7
5 - 10 years 3
10 years or more 1
Adherence
Adherence Evaluations Percentage
Always 93
Usually 15
Sometimes 3
Never taken as prescribed 1
Burden
Burden Evaluations Percentage
Very hard to take 2
Somewhat hard to take 2
A little hard to take 10
Not at all hard to take 98
Cost per month
Cost per month Evaluations Percentage
$200+ 0
$100-199 5
$50-99 22
$25-49 28
< $25 25
Not specified 32
Last updated:

7 patient evaluations for Methylfolate (l-methylfolate)

Jun 30, 2016 (Started Oct 15, 2012)

  • Effectiveness
    Moderate (for depressed mood)
  • Effectiveness
    Moderate (for Increase effect of another treatment)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 7.5 mg Daily
Cost: $50-99 monthly

Feb 25, 2013 (Started Oct 15, 2012)

  • Effectiveness
    Major (for Increase effect of another treatment)
  • Effectiveness
    Major (for depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 7.5 mg Daily
Cost: $50-99 monthly

  • 0 helpful marks

Oct 23, 2015 (Started Jan 16, 2015)

  • Effectiveness
    Moderate (for nerve damage)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: Twice daily
Cost: $25-49 monthly

Apr 14, 2015 (Started Jan 16, 2015)

  • Effectiveness
    Major (for nerve damage)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: Twice daily
Cost: $25-49 monthly

  • 0 helpful marks

Aug 5, 2012 (Started Jan 12, 2012)

  • Effectiveness
    Major (for depressed mood)
  • Effectiveness
    Major (for myalgic encephalomyelitis/chronic fatigue syndrome)
  • Effectiveness
    Moderate (for fatigue)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 15 mg Daily
Cost: $50-99 monthly

Aug 4, 2012 (Started Jan 12, 2012)

  • Effectiveness
    Major (for depressed mood)
  • Effectiveness
    Can't tell (for myalgic encephalomyelitis/chronic fatigue syndrome)
  • Effectiveness
    Can't tell (for fatigue)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 15 mg Daily

  • 0 helpful marks
Last updated:
Showing 3 of 7 patient evaluations for Methylfolate (l-methylfolate)