What is Methotrexate?

Category: Prescription Drugs

Most popular types: Apo-Methotrexate Trexall Rheumatrex Dose Pack Show all

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See also: Methotrexate-Vinblastine-Doxorubicin-Cisplatin (MVAC)

Methotrexate is an antineoplastic drug used in the treatment of cancer and other chronic conditions. It is given by mouth, by injection, via IV or intrathecally, or topically.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Rheumatoid arthritis 12955 727
Systemic lupus erythematosus 3902 162
Psoriasis 964 87
Psoriatic arthritis 862 111
Crohn's disease 291 19
Mixed connective tissue disease 266 28

Show all 155 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 264
Moderate 346
Mild 292
None 324

Commonly reported side effects and conditions associated with Methotrexate

Side effect Patients Percentage
Nausea 280
Fatigue 128
Hair loss 106
Headaches 61
Mouth sores (ulcers) 46
Diarrhea 38

Show all 257 reported side effects

Dosages

Based on patients currently taking Methotrexate

Dosage Patients Percentage
15 mg weekly 11
20 mg weekly 7
10 mg weekly 6
2.5 mg weekly 4
6 tablet(s) weekly 3
25 mg weekly 3
0.6 mL weekly 2
7.5 mg weekly 2
12.5 mg weekly 2
17.5 mg weekly 2

See all 26 dosages

Why patients stopped taking Methotrexate

Multiple reasons could be selected

Reason Patients Percentage
Side effects too severe 535
Did not seem to work 269
Doctor's advice 266
Other 122
Course of treatment ended 53
Personal research 29
Change in health plan coverage 15
Expense 14
See all 926 patients who've stopped taking Methotrexate

Duration

Currently taking Methotrexate

Duration Patients Percentage
1 - 6 months 7
6 months - 1 year 3
1 - 2 years 3
2 - 5 years 13
5 - 10 years 16
10 years or more 21

Stopped taking Methotrexate

Duration Patients Percentage
Less than 1 month 142
1 - 6 months 183
6 months - 1 year 167
1 - 2 years 125
2 - 5 years 170
5 - 10 years 68
10 years or more 39
Adherence
Adherence Evaluations Percentage
Always 1015
Usually 124
Sometimes 21
Never taken as prescribed 66
Burden
Burden Evaluations Percentage
Very hard to take 98
Somewhat hard to take 177
A little hard to take 204
Not at all hard to take 747
Cost per month
Cost per month Evaluations Percentage
$200+ 9
$100-199 6
$50-99 23
$25-49 52
< $25 559
Not specified 577

What people switch to and from

Patients started taking Methotrexate after stopping:

Treatment Patients Percentage
Hydroxychloroquine (Plaquenil) 86
Prednisone (Prednisone Intensol) 41
Sulfasalazine (Salazopyrin) 20
Azathioprine (Imuran) 16
Leflunomide (Arava) 13

Show all 45 treatments patients report switching from

Patients stopped taking Methotrexate and switched to:

Treatment Patients Percentage
Leflunomide (Arava) 61
Azathioprine (Imuran) 43
Etanercept (Enbrel) 43
Adalimumab (Humira) 42
Hydroxychloroquine (Plaquenil) 41

Show all 51 treatments patients report switching to

Last updated:

44 patient evaluations for Methotrexate

May 12, 2018 (Started Feb 03, 2010)

  • Effectiveness
    Can't tell (for chronic inflammatory demyelinating polyneuropathy)
  • Side effects
    None (for Overall)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 5 mg Weekly
Cost: < $25 monthly

  • 0 helpful marks

Jul 1, 2015 (Started Apr 01, 2011)

  • Effectiveness
    Moderate (for rheumatoid arthritis)
  • Side effects
    Moderate (for Overall) (cognitive impairment)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 0.8 mL Weekly
Cost: < $25 monthly

Apr 15, 2012 (Started Apr 01, 2011)

  • Effectiveness
    Major (for rheumatoid arthritis)
  • Side effects
    Mild (for Overall) (cognitive impairment)
  • Adherence
    Usually
  • Burden
    A little hard to take
Cost: < $25 monthly

Apr 13, 2012 (Started Apr 01, 2011)

  • Effectiveness
    Moderate (for rheumatoid arthritis)
  • Side effects
    Mild (for Overall) (cognitive impairment)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 20 mg Weekly
Advice & Tips: Methotrexate injections have been more beneficial than the oral form. The side effects are way less on injections. It still makes me feel slow and sleepy for a day or two after but not nauseous. When I was taking the oral form I would always only be able to sleep for six hours, then have to take a nap two hours after I would get up the day after I took the weekly dose. I had to stop taking my shot because I got a lung infection.
Cost: < $25 monthly

  • 0 helpful marks

Jul 21, 2016 (Started Nov 15, 2015)

  • Effectiveness
    Moderate (for Crohn's disease)
  • Effectiveness
    Major (for rheumatoid arthritis)
  • Side effects
    Moderate (for Overall) (grogginess)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg Weekly
Advice & Tips: Allow time to adjust after taking it for tiredness and very groggy and hard to focus. It is good for getting more than usual sleep.
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 44 patient evaluations for Methotrexate