What is Methotrexate?

Category: Prescription Drugs

Most popular types: Trexall Apo-Methotrexate Rheumatrex Dose Pack Show all

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See also: Methotrexate-Vinblastine-Doxorubicin-Cisplatin (MVAC)

Methotrexate is an antineoplastic drug used in the treatment of cancer. Also used as an antirheumatic for rheumatoid arthritis. It may also be used in treatment of Crohn's disease, ectopic pregnancy, or MS. It is given by mouth, by injection, via IV or intrathecally.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Rheumatoid arthritis 1633 663
Systemic lupus erythematosus 343 146
Psoriatic arthritis 213 104
Psoriasis 188 89
Multiple sclerosis 72 39

Show all 120 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 252
Moderate 326
Mild 267
None 277

Commonly reported side effects and conditions associated with Methotrexate

Side effect Patients Percentage
Nausea 273
Fatigue 126
Hair loss 101
Headaches 59
Mouth sores (ulcers) 44
Diarrhea 34

Show all 249 reported side effects

Dosages

Based on patients currently taking Methotrexate

Dosage Patients Percentage
15 mg weekly 33
20 mg weekly 23
10 mg weekly 22
12.5 mg weekly 13
25 mg weekly 12
7.5 mg weekly 10
17.5 mg weekly 9
0.8 mL weekly 4
2.5 mg weekly 3
30 mg weekly 3

See all 43 dosages

Why patients stopped taking Methotrexate

Multiple reasons could be selected

Reason Patients Percentage
Side effects too severe 505
Did not seem to work 256
Doctor's advice 248
Other 113
Course of treatment ended 51
Personal research 28
Change in health plan coverage 14
Expense 14
See all 863 patients who've stopped taking Methotrexate

Duration

Currently taking Methotrexate

Duration Patients Percentage
Less than 1 month 1
1 - 6 months 6
6 months - 1 year 4
1 - 2 years 25
2 - 5 years 50
5 - 10 years 54
10 years or more 38

Stopped taking Methotrexate

Duration Patients Percentage
Less than 1 month 139
1 - 6 months 184
6 months - 1 year 162
1 - 2 years 123
2 - 5 years 162
5 - 10 years 62
10 years or more 34
Adherence
Adherence Evaluations Percentage
Always 932
Usually 116
Sometimes 17
Never taken as prescribed 57
Burden
Burden Evaluations Percentage
Very hard to take 87
Somewhat hard to take 163
A little hard to take 185
Not at all hard to take 687
Cost per month
Cost per month Evaluations Percentage
$200+ 8
$100-199 6
$50-99 24
$25-49 52
< $25 533
Not specified 499

What people switch to and from

Patients started taking Methotrexate after stopping:

Treatment Patients Percentage
Hydroxychloroquine (Plaquenil) 66
Prednisone (Deltasone) 32
Sulfasalazine (Salazopyrin) 17
Azathioprine (Imuran) 13
Leflunomide (Arava) 11

Show all 45 treatments patients report switching from

Patients stopped taking Methotrexate and switched to:

Treatment Patients Percentage
Leflunomide (Arava) 40
Etanercept (Enbrel SureClick) 26
Azathioprine (Imuran) 22
Hydroxychloroquine (Plaquenil) 19
Sulfasalazine (Salazopyrin) 19

Show all 38 treatments patients report switching to

Last updated:

46 patient evaluations for Methotrexate

May 12, 2018 (Started Feb 03, 2010)

  • Effectiveness
    Can't tell (for chronic inflammatory demyelinating polyneuropathy)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 5 mg Weekly
Cost: < $25 monthly

  • 0 helpful marks

Dec 8, 2016 (Started Apr 10, 2014)

  • Effectiveness
    Moderate (for psoriasis)
  • Side effects
    Moderate (upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Weekly
Advice & Tips: Started on pills and then added til maxed then went to shots because of stomach issues. Stopped after starting a new treatment It worked for awhile but then it stopped working.

Jul 1, 2015 (Started Apr 10, 2014)

  • Effectiveness
    Moderate (for psoriasis)
  • Effectiveness
    Slight (for psoriatic arthritis)
  • Side effects
    Mild (upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 15 mg Weekly

  • 0 helpful marks

Jul 21, 2016 (Started Nov 15, 2015)

  • Effectiveness
    Moderate (for Crohn's disease)
  • Effectiveness
    Major (for rheumatoid arthritis)
  • Side effects
    Moderate (grogginess)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg Weekly
Advice & Tips: Allow time to adjust after taking it for tiredness and very groggy and hard to focus. It is good for getting more than usual sleep.
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 46 patient evaluations for Methotrexate