What is Methotrexate?

Category: Prescription Drugs

Most popular types: Trexall Apo-Methotrexate Rheumatrex Dose Pack Show all

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See also: Methotrexate-Vinblastine-Doxorubicin-Cisplatin (MVAC)

Methotrexate is an antineoplastic drug used in the treatment of cancer. Also used as an antirheumatic for rheumatoid arthritis. It may also be used in treatment of Crohn's disease, ectopic pregnancy, or MS. It is given by mouth, by injection, via IV or intrathecally.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Rheumatoid arthritis 1647 674
Systemic lupus erythematosus 344 146
Psoriatic arthritis 213 104
Psoriasis 188 89
Multiple sclerosis 72 39

Show all 120 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 254
Moderate 333
Mild 269
None 279

Commonly reported side effects and conditions associated with Methotrexate

Side effect Patients Percentage
Nausea 277
Fatigue 127
Hair loss 103
Headaches 61
Mouth sores (ulcers) 43
Diarrhea 37

Show all 250 reported side effects

Dosages

Based on patients currently taking Methotrexate

Dosage Patients Percentage
15 mg weekly 28
20 mg weekly 18
10 mg weekly 13
12.5 mg weekly 12
25 mg weekly 10
17.5 mg weekly 7
7.5 mg weekly 5
0.8 mL weekly 3
2.5 mg weekly 3
50 mg weekly 2

See all 29 dosages

Why patients stopped taking Methotrexate

Multiple reasons could be selected

Reason Patients Percentage
Side effects too severe 505
Did not seem to work 256
Doctor's advice 248
Other 113
Course of treatment ended 51
Personal research 28
Change in health plan coverage 14
Expense 14
See all 864 patients who've stopped taking Methotrexate

Duration

Currently taking Methotrexate

Duration Patients Percentage
Less than 1 month 1
1 - 6 months 11
6 months - 1 year 5
1 - 2 years 17
2 - 5 years 40
5 - 10 years 31
10 years or more 29

Stopped taking Methotrexate

Duration Patients Percentage
Less than 1 month 139
1 - 6 months 184
6 months - 1 year 160
1 - 2 years 125
2 - 5 years 163
5 - 10 years 62
10 years or more 34
Adherence
Adherence Evaluations Percentage
Always 945
Usually 116
Sometimes 17
Never taken as prescribed 57
Burden
Burden Evaluations Percentage
Very hard to take 87
Somewhat hard to take 167
A little hard to take 187
Not at all hard to take 694
Cost per month
Cost per month Evaluations Percentage
$200+ 8
$100-199 6
$50-99 24
$25-49 52
< $25 538
Not specified 507

What people switch to and from

Patients started taking Methotrexate after stopping:

Treatment Patients Percentage
Hydroxychloroquine (Plaquenil) 67
Prednisone (Deltasone) 32
Sulfasalazine (Salazopyrin) 17
Azathioprine (Imuran) 13
Leflunomide (Arava) 11

Show all 45 treatments patients report switching from

Patients stopped taking Methotrexate and switched to:

Treatment Patients Percentage
Leflunomide (Arava) 41
Etanercept (Enbrel SureClick) 27
Azathioprine (Imuran) 24
Hydroxychloroquine (Plaquenil) 19
Sulfasalazine (Salazopyrin) 19

Show all 38 treatments patients report switching to

Last updated:

46 patient evaluations for Methotrexate

May 12, 2018 (Started Feb 03, 2010)

  • Effectiveness
    Can't tell (for chronic inflammatory demyelinating polyneuropathy)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 5 mg Weekly
Cost: < $25 monthly

  • 0 helpful marks

Dec 8, 2016 (Started Apr 10, 2014)

  • Effectiveness
    Moderate (for psoriasis)
  • Side effects
    Moderate (upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Weekly
Advice & Tips: Started on pills and then added til maxed then went to shots because of stomach issues. Stopped after starting a new treatment It worked for awhile but then it stopped working.

Jul 1, 2015 (Started Apr 10, 2014)

  • Effectiveness
    Moderate (for psoriasis)
  • Effectiveness
    Slight (for psoriatic arthritis)
  • Side effects
    Mild (upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 15 mg Weekly

  • 0 helpful marks

Jul 21, 2016 (Started Nov 15, 2015)

  • Effectiveness
    Moderate (for Crohn's disease)
  • Effectiveness
    Major (for rheumatoid arthritis)
  • Side effects
    Moderate (grogginess)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg Weekly
Advice & Tips: Allow time to adjust after taking it for tiredness and very groggy and hard to focus. It is good for getting more than usual sleep.
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 46 patient evaluations for Methotrexate