What is Leflunomide?

Category: Prescription Drugs

Most popular types: Arava

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Leflunomide is a disease modifying antirheumatic drug used to treat active rheumatoid arthritis to reduce symptoms, retard structural damage and improve physical function. Also use as to prevent rejection in organ transplants.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Rheumatoid arthritis 342 137
Systemic lupus erythematosus 37 21
Psoriatic arthritis 16 17
Arthritis pain 4 1
BK virus 4 0

Show all 25 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 40
Moderate 43
Mild 41
None 58

Commonly reported side effects and conditions associated with Leflunomide

Side effect Patients Percentage
Diarrhea 21
Nausea 13
Hair loss 11
Headaches 5
Elevated liver enzymes 4
Weight loss 4

Show all 66 reported side effects

Dosages

Based on patients currently taking Leflunomide

Dosage Patients Percentage
20 mg daily 16
10 mg daily 6
10 mg twice daily 1

Why patients stopped taking Leflunomide

Multiple reasons could be selected

Reason Patients Percentage
Side effects too severe 88
Did not seem to work 73
Doctor's advice 61
Other 18
Expense 8
Personal research 5
Course of treatment ended 3
See all 178 patients who've stopped taking Leflunomide

Duration

Currently taking Leflunomide

Duration Patients Percentage
1 - 6 months 1
1 - 2 years 1
2 - 5 years 10
5 - 10 years 9
10 years or more 3

Stopped taking Leflunomide

Duration Patients Percentage
Less than 1 month 34
1 - 6 months 56
6 months - 1 year 40
1 - 2 years 23
2 - 5 years 20
5 - 10 years 6
10 years or more 2
Adherence
Adherence Evaluations Percentage
Always 156
Usually 8
Sometimes 4
Never taken as prescribed 14
Burden
Burden Evaluations Percentage
Very hard to take 12
Somewhat hard to take 9
A little hard to take 16
Not at all hard to take 145
Cost per month
Cost per month Evaluations Percentage
$200+ 5
$100-199 3
$50-99 8
$25-49 20
< $25 76
Not specified 70

What people switch to and from

Patients started taking Leflunomide after stopping:

Treatment Patients Percentage
Methotrexate (Trexall) 55
Hydroxychloroquine (Plaquenil) 20
Sulfasalazine (Salazopyrin) 6
Azathioprine (Imuran) 5
Etanercept (Enbrel SureClick) 4

Show all 14 treatments patients report switching from

Patients stopped taking Leflunomide and switched to:

Treatment Patients Percentage
Methotrexate (Trexall) 10
Etanercept (Enbrel SureClick) 7
Adalimumab (Humira) 6
Azathioprine (Imuran) 5
Sulfasalazine (Salazopyrin) 5

Show all 16 treatments patients report switching to

Last updated:

5 patient evaluations for Leflunomide

Dec 6, 2016 (Started Jan 30, 2014)

  • Effectiveness
    None (for rheumatoid arthritis)
  • Side effects
    Moderate (upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 mg Daily
Cost: < $25 monthly

May 15, 2014 (Started Jan 30, 2014)

  • Effectiveness
    None (for rheumatoid arthritis)
  • Side effects
    Moderate (upset stomach)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily

  • 0 helpful marks

Mar 16, 2012 (Started Dec 12, 2011)

  • Effectiveness
    None (for rheumatoid arthritis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 mg Daily
Cost: < $25 monthly

  • 0 helpful marks

Jul 4, 2011 (Started Apr 15, 2011)

  • Effectiveness
    Can't tell (for rheumatoid arthritis)
  • Side effects
    Severe
  • Adherence
    Always
  • Burden
    Very hard to take
Dosage: 20 mg Daily

  • 0 helpful marks
Last updated:
Showing 3 of 5 patient evaluations for Leflunomide