What is L-Arginine?

Category: Supplements

Most popular types: ARG Matrix


L-arginine is an amino acid that does a variety of things in the body including getting rid of ammonia and helping in the formation of proteins. L-arginine also reduces stiffness of the blood vessels and supplements may help with conditions that improve when blood vessels are relaxed.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
General health 14 2
Amyotrophic lateral sclerosis 6 2
Fatigue 6 0
Improve flexibility/strength 2 1
Support circulatory health 2 0
Support immune health 2 1

Show all 20 reasons taken

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 1
Moderate 4
Mild 0
None 8

Commonly reported side effects and conditions associated with L-Arginine

Side effect Patients Percentage
Abdominal bloating 1
Anxious mood 1
Dehydration 1
Depressed mood 1
Irritability 1
Low oxygen saturation while sleeping 1

Show all 10 reported side effects


Based on patients currently taking L-Arginine

Dosage Patients Percentage
500 mg daily 1
1000 mg twice daily 1

Why patients stopped taking L-Arginine

Multiple reasons could be selected

Reason Patients Percentage
Other 7
Did not seem to work 4
Side effects too severe 2
Expense 1
Personal research 1
See all 13 patients who've stopped taking L-Arginine


Currently taking L-Arginine

Duration Patients Percentage
1 - 2 years 2

Stopped taking L-Arginine

Duration Patients Percentage
Less than 1 month 1
1 - 6 months 4
6 months - 1 year 4
1 - 2 years 3
2 - 5 years 1
Adherence Evaluations Percentage
Always 7
Usually 3
Sometimes 3
Never taken as prescribed 0
Burden Evaluations Percentage
Very hard to take 1
Somewhat hard to take 1
A little hard to take 2
Not at all hard to take 9
Cost per month
Cost per month Evaluations Percentage
$200+ 0
$100-199 0
$50-99 0
$25-49 2
< $25 4
Not specified 7
Last updated:

2 patient evaluations for L-Arginine

Dec 10, 2012 (Started Jun 01, 2012)

  • Effectiveness
    None (for amyotrophic lateral sclerosis)
  • Side effects
  • Adherence
  • Burden
    Not at all hard to take
Dosage: 3000 mg Daily
Cost: < $25 monthly

  • 0 helpful marks

Apr 27, 2009 (Started Apr 21, 2009)

  • Effectiveness
    Slight (for Other)
  • Side effects
    Severe (depressed mood, anxious mood, rage, suicidal thoughts or urges, irritability)
  • Adherence
  • Burden
    Very hard to take
Dosage: 2000 mg Daily
Advice & Tips: I began this treatment as an attempt to potentiate/augment the slowly diminishing stimulatory (energy) and concentration/memory effect from Nardil. L-Arginine metabolism involves the production of nitric oxide (NO) which releases dopamine (among other things) in the brain. Dopamine is responsible for memory and cognition and, in turn, is metabolized into norepinephrine and adrenalin for energy. Seemed like an ideal supplement to bring back these effects on Nardil. In reality (for me) it actually increased my anxiety/irritation horribly which cycled with depressive episodes. These effects were dose related in my experiment and began at 500mg 3 times a day (dose too high for me). My advice would be to start this supplement at minimal doses when on an antidepressant and work your way up slowly, if needed. I find it a good supplement when used at smaller doses (i.e. 250mg) and taken only 1 or 2 times a day on an empty stomach with lots of water (avoids nausea; decreases stomach acid buildup; dilutes high urea concentration). It may provide you with a nice stimulation effect you can feel buzzing through you as well as clarity of mind, both of which are good AD augments. Higher doses will inhibit cognitive and memory abilities. Take in morning and afternoon as night dosing may increase insomnia. Drink lots of water throughout the day to flush out highly concentrated urea. These are my observations from use on Nardil....your experiences may be different
Side effects: anxious mood, suicidal thoughts or urges, rage, depressed mood, irritability

  • 0 helpful marks
Last updated:
Showing 2 of 2 patient evaluations for L-Arginine