What is Intravenous Immunoglobulin (IVIG)?

Category: Prescription Drugs

Most popular types: Gammaglobulin (IVIg) Gammagard Gamunex Show all

false

Intravenous Immune Globulin (IVIG) is a human blood product consisting of antibodies which is used to treat immunodeficiency disorders, B-cell chronic lymphocytic leukemia, inflammatory demyelinating disorders. It may also be used to treat Guillain-Barré, Multiple Sclerosis, and myasthenia gravis.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple sclerosis 75 53
Chronic inflammatory demyelinating polyneuropathy 58 30
Myasthenia gravis 54 35
Hypogammaglobulinemia 53 49
Common variable immune deficiency 41 32
Multifocal motor neuropathy 21 27

Show all 102 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 36
Moderate 71
Mild 127
None 87

Commonly reported side effects and conditions associated with Intravenous Immunoglobulin (IVIG)

Side effect Patients Percentage
Headaches 84
Fatigue 27
Nausea 26
Migraine headaches 22
Fever/chills 11
Aseptic meningitis 7

Show all 125 reported side effects

Dosages

Based on patients currently taking Intravenous Immunoglobulin (IVIG)

Dosage Patients Percentage
100 mg monthly 3
10 g monthly 2
30 mg monthly 2
50 mg monthly 2
50 mg every other week 2
100 mg every other week 2
1 other every 3 weeks 1
4 hr monthly 1
5 g monthly 1
5 mg every other week 1

See all 31 dosages

Why patients stopped taking Intravenous Immunoglobulin (IVIG)

Multiple reasons could be selected

Reason Patients Percentage
Did not seem to work 75
Course of treatment ended 67
Doctor's advice 55
Side effects too severe 34
Other 30
Change in health plan coverage 15
Expense 15
Personal research 3
See all 216 patients who've stopped taking Intravenous Immunoglobulin (IVIG)

Duration

Currently taking Intravenous Immunoglobulin (IVIG)

Duration Patients Percentage
1 - 6 months 1
6 months - 1 year 2
1 - 2 years 7
2 - 5 years 17
5 - 10 years 7
10 years or more 8

Stopped taking Intravenous Immunoglobulin (IVIG)

Duration Patients Percentage
Less than 1 month 76
1 - 6 months 55
6 months - 1 year 26
1 - 2 years 25
2 - 5 years 26
5 - 10 years 10
10 years or more 6
Adherence
Adherence Evaluations Percentage
Always 281
Usually 14
Sometimes 2
Never taken as prescribed 24
Burden
Burden Evaluations Percentage
Very hard to take 35
Somewhat hard to take 100
A little hard to take 91
Not at all hard to take 95
Cost per month
Cost per month Evaluations Percentage
$200+ 53
$100-199 5
$50-99 2
$25-49 8
< $25 87
Not specified 166

What people switch to and from

Patients started taking Intravenous Immunoglobulin (IVIG) after stopping:

Treatment Patients Percentage
Subcutaneous immune globulin (Hizentra) 4
Azathioprine (Imuran) 3
Methotrexate (Trexall) 3
Methylprednisolone (Solu-Medrol Infusion) 3
Mycophenolate mofetil (CellCept) 3

Show all 17 treatments patients report switching from

Patients stopped taking Intravenous Immunoglobulin (IVIG) and switched to:

Treatment Patients Percentage
Subcutaneous immune globulin (Hizentra) 13
Rituximab (Rituxan) 4
Intravenous Immunoglobulin (IVIG) (Gammaglobulin (IVIg)) 2
Prednisone (Deltasone) 2
Cyclophosphamide (Cytoxan) 1

Show all 13 treatments patients report switching to

Last updated:

15 patient evaluations for Intravenous Immunoglobulin (IVIG)

Apr 6, 2018 (Started Nov 12, 2015)

  • Effectiveness
    Major (for hypogammaglobulinemia)
  • Side effects
    Mild (fatigue, migraine, abdominal pain, weight gain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 g Monthly
Advice & Tips: Continuing to infuse the D5NS with my Gammagard. It makes a huge difference with my side effects. I also don't gain as much weight, however I have to make sure to not take my diuretics for a couple days afterwards or else I get a massive headache.

Jan 16, 2017 (Started Nov 12, 2015)

  • Effectiveness
    Major (for hypogammaglobulinemia)
  • Side effects
    Mild (fatigue, migraine, abdominal pain, weight gain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 g Monthly
Advice & Tips: My 12/6/16 infusion had a lot fewer side effects the next day and also the night of. My new immunologist had D5NS infuse at 20 mL/hr in addition to the Gammagard Liquid at my maximum tolerable rate of 40 mL/hr. Having the D5NS really seemed to make a big difference in the decreased side effects. Basically I was just really fatigued for a couple days.

Aug 27, 2016 (Started Nov 12, 2015)

  • Effectiveness
    Major (for hypogammaglobulinemia)
  • Side effects
    Mild (fatigue, migraine, abdominal pain, weight gain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 g Monthly
Advice & Tips: With the Gammagard, I have noticed that my weight jumps about 9 pounds after each infusion. The weight change takes place overnight and after about 7 days, my weight is back to baseline. My insurance requires a new prior authorization every 3 months, which makes it something else that I have to keep tabs on. 

Nov 16, 2015 (Started Nov 12, 2015)

  • Effectiveness
    Can't tell (for hypogammaglobulinemia)
  • Side effects
    Moderate (fatigue, migraine, abdominal pain, weight gain)
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 25 g Monthly

  • 1 helpful mark

Nov 1, 2015 (Started May 15, 2015)

  • Effectiveness
    Major (for hypogammaglobulinemia)
  • Side effects
    Moderate (abdominal pain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25000 mg Monthly

  • 0 helpful marks

Jul 20, 2015 (Started Jun 22, 2015)

  • Effectiveness
    None (for myasthenia gravis)
  • Side effects
    Severe (allergic reaction)
  • Adherence
    Never taken as prescribed
  • Burden
    Very hard to take
Advice & Tips: After 15 min at a drip of 36ml an hr....the ivig was turned off due to my body rejecting treatment with allergic reactions or flushing, numbness in mouth and starting of angioedema.

  • 1 helpful mark
Last updated:
Showing 3 of 15 patient evaluations for Intravenous Immunoglobulin (IVIG)