What is 5-methyltetrahydrofolate (5-MTHF)?

Category: Supplements

Most popular types: FolaPro

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5-MTHF is an acronym for 5-methyltetrahydrofolate, also known as L-5-methyltetrahydrofolate (L-5-MTHF). It is the metabolically active form of folic acid that plays a role in DNA synthesis and repair.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Methylenetetrahydrofolate reductase deficiency 9 4
Folic acid deficiency 5 5
Fibromyalgia 2 2
Major depressive disorder 2 2
Amyotrophic lateral sclerosis 1 0
Autoimmune disease undefined 1 1

Show all 11 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 0
Moderate 0
Mild 0
None 13

Commonly reported side effects and conditions associated with 5-methyltetrahydrofolate (5-MTHF)

Side effect Patients Percentage

Dosages

Based on patients currently taking 5-methyltetrahydrofolate (5-MTHF)

Dosage Patients Percentage
1 mg daily 3
1 mg weekly 1
10 mg daily 1
400 mcg daily 1
750 mcg daily 1

Why patients stopped taking 5-methyltetrahydrofolate (5-MTHF)

Multiple reasons could be selected

Reason Patients Percentage
Did not seem to work 4
Expense 4
Course of treatment ended 2
Other 2
Doctor's advice 1
See all 9 patients who've stopped taking 5-methyltetrahydrofolate (5-MTHF)

Duration

Currently taking 5-methyltetrahydrofolate (5-MTHF)

Duration Patients Percentage
Less than 1 month 1
1 - 2 years 2
2 - 5 years 1
5 - 10 years 3

Stopped taking 5-methyltetrahydrofolate (5-MTHF)

Duration Patients Percentage
Less than 1 month 1
1 - 6 months 3
6 months - 1 year 1
1 - 2 years 1
2 - 5 years 3
Adherence
Adherence Evaluations Percentage
Always 10
Usually 3
Sometimes 0
Never taken as prescribed 0
Burden
Burden Evaluations Percentage
Very hard to take 0
Somewhat hard to take 0
A little hard to take 2
Not at all hard to take 11
Cost per month
Cost per month Evaluations Percentage
$200+ 0
$100-199 1
$50-99 2
$25-49 2
< $25 4
Not specified 4
Last updated:

1 patient evaluation for 5-methyltetrahydrofolate (5-MTHF)

May 9, 2019 (Started Apr 15, 2019)

  • Effectiveness
    Major (for fibromyalgia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 750 mcg Daily
Advice & Tips: I started taking 7.5mg of folate in Aril '19
Cost: < $25 monthly

Aug 14, 2012 (Started Apr 15, 2019)

  • Effectiveness
    Major (for Methylation)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: In patients afflicted with Fibromyalgia and Chronic Fatigue Syndrome, the methionine synthase reaction is partially blocked, therefore Folic acid (Methylfolate) cannot be converted to folinic acid. Without Methylation, the body is unable to produce vital substances like Glutathione, Methionine, etc., which in turn stifles vital functions, such as detoxification of Heavy metals like Mercury, etc. The Methylation Protocol at: <http://www.fightingfatigue.org/?p=8994>
Cost: < $25 monthly

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Last updated:
Showing 1 of 1 patient evaluation for 5-methyltetrahydrofolate (5-MTHF)