What is Estradiol?

Category: Prescription Drugs

Most popular types: Estrace Vivelle-Dot Patch Climara HRT patch Show all


See also: Bi-Est Dienogest-Estradiol Estradiol-norethindrone Estrogen patch Maxim Natazia

Estradiol, an estrogen derivative is used to treat menopausal symptoms, vaginal atrophy, hypoestrogenism; palliation of prostate and breast cancer; prevention of osteoporosis; abnormal uterine bleeding; and postmenopausal urinary symptoms (urgency, dysuria).

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Hormone replacement 36 16
General health 34 13
Hot flashes 21 7
Support hormone balance 11 2
Gender dysphoria 10 12

Show all 41 reasons taken

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 6
Moderate 13
Mild 24
None 96

Commonly reported side effects and conditions associated with Estradiol

Side effect Patients Percentage
Weight gain 3
Breast tenderness 2
Fatigue 2
Headaches 2
Hot flashes 2
Migraine headaches 2

Show all 27 reported side effects


Based on patients currently taking Estradiol

Dosage Patients Percentage
1 mg daily 15
0.5 mg daily 10
2 mg daily 7
4 mg daily 3
0.1 % daily 2
1.04 mcg weekly 2
3 mg daily 2
6 mg daily 2
0.01 g weekly 1
0.0375 mcg weekly 1

See all 35 dosages

Why patients stopped taking Estradiol

Multiple reasons could be selected

Reason Patients Percentage
Doctor's advice 25
Other 20
Did not seem to work 11
Expense 7
Course of treatment ended 6
Personal research 5
Side effects too severe 5
Change in health plan coverage 4
See all 74 patients who've stopped taking Estradiol


Currently taking Estradiol

Duration Patients Percentage
1 - 6 months 2
6 months - 1 year 1
1 - 2 years 12
2 - 5 years 18
5 - 10 years 11
10 years or more 26

Stopped taking Estradiol

Duration Patients Percentage
Less than 1 month 2
1 - 6 months 14
6 months - 1 year 9
1 - 2 years 14
2 - 5 years 20
5 - 10 years 8
10 years or more 8
Adherence Evaluations Percentage
Always 93
Usually 33
Sometimes 3
Never taken as prescribed 10
Burden Evaluations Percentage
Very hard to take 5
Somewhat hard to take 14
A little hard to take 18
Not at all hard to take 102
Cost per month
Cost per month Evaluations Percentage
$200+ 0
$100-199 2
$50-99 11
$25-49 10
< $25 63
Not specified 53

What people switch to and from

Patients started taking Estradiol after stopping:

Treatment Patients Percentage
Estrogen derivative (Premarin) 13
Estradiol (Estrace) 4
Estradiol Patch (Estrogen patch) 4
Bioidentical hormones (Bioidentical hormone cream) 2
Esterified estrogen-methyltestosterone (Estratest) 1

Show all 9 treatments patients report switching from

Patients stopped taking Estradiol and switched to:

Treatment Patients Percentage
Estradiol (Estrace) 3
Estrogen derivative (Premarin) 3
Estradiol Patch (Estrogen patch) 2
Estradiol topical (Estrace Vaginal Cream) 1
ethinyl estradiol-norgestimate (Ortho Tri-Cyclen) 1

Show all 8 treatments patients report switching to

Last updated:

13 patient evaluations for Estradiol

Jan 15, 2012 (Started Apr 01, 2007)

  • Effectiveness
    Slight (for menopause)
  • Side effects
  • Adherence
  • Burden
    Not at all hard to take
Dosage: 1 mg Daily
Advice & Tips: I found that the side effects were undesirable (hair falling out). Adverse effects, which may occur as a result of use of estradiol and have been associated with estrogen and/or progestin therapy, include changes in vaginal bleeding, dysmenorrhea, increase in size of uterine leiomyomata, vaginitis including vaginal candidiasis, changes in cervical secretion and cervical ectropion, ovarian cancer, endometrial hyperplasia, endometrial cancer, nipple discharge, galactorrhea, fibrocystic breast changes and breast cancer. Cardiovascular effects include chest pain, deep and superficial venous thrombosis, pulmonary embolism, thrombophlebitis, myocardial infarction, stroke, and increased blood pressure. Gastrointestinal effects include nausea and vomiting, abdominal cramps, bloating, diarrhea, dyspepsia, dysuria, gastritis, cholestatic jaundice, increased incidence of gallbladder disease, pancreatitis, or enlargement of hepatic hemangiomas. Skin adverse effects include chloasma or melasma that may continue despite discontinuation of the drug. Other effects on the skin include erythema multiforme, erythema nodosum, otitis media, hemorrhagic eruption, loss of scalp hair, hirsutism, pruritus, or rash. Adverse effects on the eyes include retinal vascular thrombosis, steepening of corneal curvature or intolerance to contact lenses. Adverse central nervous system effects include headache, migraine, dizziness, mental depression, chorea, nervousness/anxiety, mood disturbances, irritability, and worsening of epilepsy. Other adverse effects include changes in weight, reduced carbohydrate tolerance, worsening of porphyria, edema, arthralgias, bronchitis, leg cramps, hemorrhoids, changes in libido, urticaria, angioedema, anaphylactic reactions, syncope, toothache, tooth disorder, urinary incontinence, hypocalcemia, exacerbation of asthma, and increased triglycerides.[21][22] Estrogen combined with medroxyprogesterone is associated with an increased risk of dementia. It is not known whether estradiol taken alone is associated with an increased risk of dementia. Estrogens should only be used for the shortest possible time and at the lowest effective dose due to these risks. Attempts to gradually reduce the medication via a dose taper should be made every three to six months.[2

  • 0 helpful marks

Oct 9, 2010 (Started Sep 20, 2010)

  • Effectiveness
    Can't tell (for hysterectomy)
  • Side effects
  • Adherence
  • Burden
    Not at all hard to take
Dosage: 2 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks

Oct 1, 2010 (Started Jan 01, 2010)

  • Effectiveness
    Moderate (for menopause)
  • Side effects
  • Adherence
  • Burden
    Not at all hard to take
Dosage: 1.5 mg Daily

  • 0 helpful marks
Last updated:
Showing 3 of 13 patient evaluations for Estradiol