What is Amitriptyline?

Category: Prescription Drugs

Most popular types: Elavil Endep Trepiline Show all

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See also: Amantadine-amitriptyline-baclofen-clonidine-lidocaine-nifedipine-prilocaine Ketoprofen, Bupivacaine, Amitriptyline, Clonidine, Gabapentin , Ketamine, Cyclobenzaprine

Amitriptyline is a tricyclic antidepressant used for the treatment of depression. It may also be used for certain chronic and neuropathic (nerve) pain and for prevention of migraine headaches.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Insomnia 1216 754
Fibromyalgia 1097 640
Pain 1047 621
Peripheral neuropathy 737 91
Spinal cord injury 239 6

Show all 320 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 293
Moderate 433
Mild 570
None 739

Commonly reported side effects and conditions associated with Amitriptyline

Side effect Patients Percentage
Dry mouth 187
Weight gain 132
Drowsiness 97
Sleepiness 63
Excessive daytime sleepiness (somnolence) 53
Grogginess 51

Show all 275 reported side effects

Dosages

Based on patients currently taking Amitriptyline

Dosage Patients Percentage
10 mg daily 28
25 mg daily 22
50 mg daily 20
20 mg daily 12
30 mg daily 12
100 mg daily 12
75 mg daily 10
150 mg daily 2
200 mg daily 2
15 mg daily 1

See all 17 dosages

Why patients stopped taking Amitriptyline

Multiple reasons could be selected

Reason Patients Percentage
Did not seem to work 524
Side effects too severe 511
Doctor's advice 285
Other 192
Course of treatment ended 61
Personal research 59
Expense 18
Change in health plan coverage 13
See all 1233 patients who've stopped taking Amitriptyline

Duration

Currently taking Amitriptyline

Duration Patients Percentage
1 - 6 months 6
6 months - 1 year 6
1 - 2 years 8
2 - 5 years 25
5 - 10 years 42
10 years or more 42

Stopped taking Amitriptyline

Duration Patients Percentage
Less than 1 month 221
1 - 6 months 321
6 months - 1 year 185
1 - 2 years 151
2 - 5 years 190
5 - 10 years 65
10 years or more 42
Adherence
Adherence Evaluations Percentage
Always 1618
Usually 252
Sometimes 76
Never taken as prescribed 89
Burden
Burden Evaluations Percentage
Very hard to take 94
Somewhat hard to take 128
A little hard to take 248
Not at all hard to take 1565
Cost per month
Cost per month Evaluations Percentage
$200+ 7
$100-199 3
$50-99 13
$25-49 29
< $25 1046
Not specified 937

What people switch to and from

Patients started taking Amitriptyline after stopping:

Treatment Patients Percentage
Duloxetine (Cymbalta) 23
Gabapentin (Neurontin) 16
Trazodone (Apo-Trazodone) 16
Pregabalin (Lyrica) 12
Zolpidem (Ambien) 11

Show all 76 treatments patients report switching from

Patients stopped taking Amitriptyline and switched to:

Treatment Patients Percentage
Gabapentin (Neurontin) 37
Nortriptyline (Pamelor) 37
Duloxetine (Cymbalta) 30
Pregabalin (Lyrica) 26
Trazodone (Apo-Trazodone) 15

Show all 75 treatments patients report switching to

Last updated:

154 patient evaluations for Amitriptyline

Nov 5, 2019 (Started Jan 15, 2019)

  • Effectiveness
    None (for persistent depressive disorder (dysthymia))
  • Effectiveness
    Slight (for fibromyalgia)
  • Side effects
    Moderate (sleepiness, dizziness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily

May 31, 2019 (Started Jan 15, 2019)

  • Effectiveness
    Slight (for persistent depressive disorder (dysthymia))
  • Effectiveness
    Slight (for fibromyalgia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 mg Daily

  • 0 helpful marks

Jun 20, 2019 (Started May 05, 2017)

  • Effectiveness
    Slight (for pain)
  • Effectiveness
    None (for neuropathy in hands)
  • Effectiveness
    Slight (for neuropathy in feet)
  • Effectiveness
    Slight (for neuropathy)
  • Side effects
    Mild (intoxicated feeling, nausea, migraine headaches)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 drop(s) Daily

May 19, 2017 (Started May 05, 2017)

  • Effectiveness
    Moderate (for neuropathy in feet)
  • Effectiveness
    Slight (for neuropathy in hands)
  • Side effects
    Moderate (intoxicated feeling, nausea, migraine headaches)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 drop(s) Daily

  • 0 helpful marks

Dec 15, 2018 (Started Apr 19, 2012)

  • Effectiveness
    Slight (for increased need for sleep)
  • Effectiveness
    Moderate (for major depressive disorder)
  • Side effects
    Mild (fluid retention weight gain, weight gain, slurred speech, hangover effect)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: Still have unexpected "depressive episodes" but they are b/c of my Major Depressive Disorder. (chemical imbalance in brain) Sometimes, I have to add an "extra" (100 mg) d/t lack of sleep/quality of sleep. But still think it's one of the best anti-depressants around. The ones that the pharmaceutical companies are cranking out have longer & longer side effects (Any advertised in magazine...takes up 3 pages!) Weight gain is something I have to fight with --along w/ post menopause, hypothyroidism, & clonazepam
Cost: < $25 monthly

Aug 13, 2018 (Started Apr 19, 2012)

  • Effectiveness
    Major (for increased need for sleep)
  • Effectiveness
    Major (for major depressive disorder)
  • Side effects
    Moderate (fluid retention weight gain, weight gain, slurred speech, hangover effect)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: Feeling hung-over in the morning & sudden impact of sleepiness after taken; take. medication right before you have eaten & are ready for bed. Its still the best anti-depressant I've EVER tried!
Cost: < $25 monthly

Dec 15, 2017 (Started Apr 19, 2012)

  • Effectiveness
    Major (for major depressive disorder)
  • Side effects
    Moderate (fluid retention weight gain, weight gain, slurred speech, hangover effect)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Cost: < $25 monthly

Nov 10, 2017 (Started Apr 19, 2012)

  • Effectiveness
    Major (for major depressive disorder)
  • Side effects
    Mild (fluid retention weight gain, weight gain, slurred speech, hangover effect)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Cost: < $25 monthly

Aug 2, 2016 (Started Apr 19, 2012)

  • Effectiveness
    Moderate (for major depressive disorder)
  • Side effects
    Mild (fluid retention weight gain, weight gain, slurred speech)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: Elavil is becoming unfamiliar with psychiatrists these days; they seem to feel that the old tricylics don't work as well as all the SSRI's that are out there now. Personally, over the vast amount of years with my psychiatrist, we tried everything from A-Z......always came back to Elavil. The SSRI's had terrible side effects & did not work as well. I think it's been quite effective! The weight gain used to be bad until I was dxed w/ Type 2 Diabetes (not on medication/just diet & exercise & glucose monitoring daily) Now I've been losing weight.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 154 patient evaluations for Amitriptyline