What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 6495 3302
Depressed mood 2107 1267
Major depressive disorder 2006 1224
Generalized anxiety disorder 801 576
Myalgic encephalomyelitis/chronic fatigue syndrome 687 379
Pain 546 325

Show all 317 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 953
Moderate 1044
Mild 1193
None 1874

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients Percentage
Weight gain 340
Nausea 299
Decreased sex drive (libido) 190
Dry mouth 181
Dizziness 167
Brain fog 118

Show all 582 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients Percentage
60 mg daily 144
30 mg daily 71
120 mg daily 48
90 mg daily 35
60 mg twice daily 34
20 mg daily 21
30 mg twice daily 9
40 mg daily 8
120 mg twice daily 6
20 mg twice daily 5

See all 28 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients Percentage
Side effects too severe 1781
Did not seem to work 1579
Doctor's advice 599
Expense 447
Other 443
Personal research 185
Change in health plan coverage 162
Course of treatment ended 70
See all 3553 patients who've stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients Percentage
1 - 6 months 13
6 months - 1 year 29
1 - 2 years 38
2 - 5 years 136
5 - 10 years 122
10 years or more 96

Stopped taking Duloxetine

Duration Patients Percentage
Less than 1 month 826
1 - 6 months 935
6 months - 1 year 555
1 - 2 years 499
2 - 5 years 550
5 - 10 years 169
10 years or more 51
Adherence
Adherence Evaluations Percentage
Always 4232
Usually 450
Sometimes 77
Never taken as prescribed 305
Burden
Burden Evaluations Percentage
Very hard to take 312
Somewhat hard to take 382
A little hard to take 588
Not at all hard to take 3782
Cost per month
Cost per month Evaluations Percentage
$200+ 124
$100-199 189
$50-99 436
$25-49 692
< $25 1658
Not specified 1965

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients Percentage
Pregabalin (Lyrica) 156
Fluoxetine (Prozac) 148
Venlafaxine (Effexor XR) 136
Sertraline (Zoloft) 124
Citalopram (Celexa) 105

Show all 82 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients Percentage
Pregabalin (Lyrica) 79
Venlafaxine (Effexor XR) 79
Gabapentin (Neurontin) 62
Escitalopram (Lexapro) 47
Sertraline (Zoloft) 43

Show all 76 treatments patients report switching to

Last updated:

318 patient evaluations for Duloxetine

Mar 31, 2020 (Started Jul 01, 2011)

  • Effectiveness
    Slight (for fibromyalgia)
  • Side effects
    Moderate (sleepiness)
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Advice & Tips: This medication caused weight gain for me. The more weight, the worse My joints felt.
Cost: < $25 monthly

  • 0 helpful marks

Jul 24, 2018 (Started Jul 01, 2014)

  • Effectiveness
    Major (for fibromyalgia)
  • Effectiveness
    Moderate (for major depressive disorder)
  • Effectiveness
    Moderate (for post-traumatic stress disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: A couple of months ago doctor Gregory added flu achsa teen and decreased duloxetine to 60 milligrams at HS.

Jul 27, 2017 (Started Jul 01, 2014)

  • Effectiveness
    Can't tell (for fibromyalgia)
  • Effectiveness
    Moderate (for major depressive disorder)
  • Effectiveness
    Can't tell (for post-traumatic stress disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: just take as directed.

  • 0 helpful marks

Jun 6, 2018 (Started Apr 15, 2014)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Effectiveness
    Major (for depressed mood)
  • Side effects
    Mild (sleepiness, excessive daytime sleepiness (somnolence))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I still think there is some kind of regulating interaction between Cymbalta and carbidopa-L-dopa. And I still can't explain or predict the sunlight /length of day effects.
Cost: < $25 monthly
Side effects: excessive daytime sleepiness (somnolence)

Sep 30, 2017 (Started Apr 15, 2014)

  • Effectiveness
    Major (for depressed mood)
  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    Mild (sleepiness, excessive daytime sleepiness (somnolence))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: The Psych Dr recommended adding 30mg Cymbalta later in the day when the 60 mg dose is used up. Not sure if and when I wil dose up to 120 mg.
Cost: < $25 monthly
Side effects: excessive daytime sleepiness (somnolence)

Mar 6, 2017 (Started Apr 15, 2014)

  • Effectiveness
    Major (for depressed mood)
  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    Mild (sleepiness, excessive daytime sleepiness (somnolence))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: I am on 2x60mg and tried to cut back to 1x in mid February. That was too soon. Also, I am waking up in the daylight hours, and am not working at UTC anymore. I am trying not to use modafinil for wakefulness.
Cost: < $25 monthly
Side effects: excessive daytime sleepiness (somnolence)

Sep 23, 2016 (Started Apr 15, 2014)

  • Effectiveness
    Moderate (for depressed mood)
  • Effectiveness
    Can't tell (for Parkinson's disease)
  • Side effects
    Moderate (sleepiness, excessive daytime sleepiness (somnolence))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: I have gone up in dosage from 60mg/day to 120mg/day, since Sept 1. Since I am ahead of my usual "sometime in Sept -Oct"schedule, Psychiatrist called it prophylactic. Said to call his office if I need to change med schedule. Aass for cost, I have met my yearly out-of-pocket, so i pay nothing.
Cost: < $25 monthly
Side effects: excessive daytime sleepiness (somnolence)

Feb 1, 2015 (Started Apr 15, 2014)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Effectiveness
    Major (for depressed mood)
  • Side effects
    Mild (sleepiness, excessive daytime sleepiness (somnolence))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I am taking 2x60mg at night, and 0.75 L-dopa every 4.25 hrs.
Cost: $25-49 monthly
Side effects: excessive daytime sleepiness (somnolence)

May 11, 2014 (Started Apr 15, 2014)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Effectiveness
    Major (for depressed mood)
  • Side effects
    Moderate (sleepiness, excessive daytime sleepiness (somnolence))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I have noticed that when taking 2x60mg, the L-dopa 25/100 can be taken 4-5 hours. When taking 60mg Cymbalta, the L-dopa is about 3-4hrs. IS it regulating the release? I like the 2x60mg. I wonder if it is causing sleepiness as I usually cut dosage in the SPringtime. It will take weeks to figure this out. I don't want to wreck my summer. Also, Cymbalta trashes the sex drive.
Cost: $25-49 monthly
Side effects: excessive daytime sleepiness (somnolence)

Apr 18, 2013 (Started Apr 15, 2014)

  • Effectiveness
    Major (for depressed mood)
  • Side effects
    Mild (sleepiness, excessive daytime sleepiness (somnolence))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: I will take this until the effectivess goes away.
Cost: $25-49 monthly
Side effects: excessive daytime sleepiness (somnolence)

Aug 23, 2011 (Started Apr 15, 2014)

  • Effectiveness
    Major (for depressed mood)
  • Side effects
    Moderate (excessive daytime sleepiness (somnolence))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: Cymbalta has been working for me for dysthymia.
Cost: $25-49 monthly
Side effects: excessive daytime sleepiness (somnolence)

  • 0 helpful marks
Last updated:
Showing 3 of 318 patient evaluations for Duloxetine