What is Diphenhydramine?

Category: Over the Counter Drugs

Most popular types: Benadryl Benadryl Allergy Simply Sleep Show all

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Diphenhydramine is an antihistamine. It is used to relieve irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold. It may also be used to prevent and treat motion sickness, or to control abnormal movements in early stage parkinsonian syndrome.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Insomnia 211 98
Food allergy 56 28
Itching 37 14
Anaphylaxis 27 15
Chemical/venom allergy 13 11

Show all 145 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 19
Moderate 62
Mild 81
None 124

Commonly reported side effects and conditions associated with Diphenhydramine

Side effect Patients Percentage
Drowsiness 35
Sleepiness 21
Dry mouth 13
Excessive daytime sleepiness (somnolence) 9
Grogginess in morning 8
Brain fog 6

Show all 51 reported side effects

Dosages

Based on patients currently taking Diphenhydramine

Dosage Patients Percentage
25mg as needed 34
25 mg daily 18
50 mg daily 15
2 25mg as needed 11
50mg as needed 9
50 mg twice daily 4
100 mg daily 3
25 mg twice daily 2
12.5mg as needed 2
2 50mg as needed 2

See all 30 dosages

Why patients stopped taking Diphenhydramine

Multiple reasons could be selected

Reason Patients Percentage
Other 66
Did not seem to work 49
Course of treatment ended 36
Doctor's advice 31
Side effects too severe 24
Personal research 11
Expense 5
Change in health plan coverage 1
See all 196 patients who've stopped taking Diphenhydramine

Duration

Currently taking Diphenhydramine

Duration Patients Percentage
Less than 1 month 2
1 - 6 months 8
6 months - 1 year 8
1 - 2 years 15
2 - 5 years 23
5 - 10 years 27
10 years or more 40

Stopped taking Diphenhydramine

Duration Patients Percentage
Less than 1 month 67
1 - 6 months 39
6 months - 1 year 25
1 - 2 years 19
2 - 5 years 21
5 - 10 years 9
10 years or more 20
Adherence
Adherence Evaluations Percentage
Always 167
Usually 70
Sometimes 38
Never taken as prescribed 11
Burden
Burden Evaluations Percentage
Very hard to take 4
Somewhat hard to take 17
A little hard to take 36
Not at all hard to take 229
Cost per month
Cost per month Evaluations Percentage
$200+ 1
$100-199 0
$50-99 1
$25-49 7
< $25 150
Not specified 127

What people switch to and from

Patients stopped taking Diphenhydramine and switched to:

Treatment Patients Percentage
Hydroxyzine (Vistaril) 4
Diphenhydramine (IV or IM) (Benadryl IV) 1
Quetiapine (Seroquel) 1
Trazodone (Desyrel) 1
Last updated:

24 patient evaluations for Diphenhydramine

Sep 22, 2016 (Started Sep 14, 2016)

  • Effectiveness
    Moderate (for allergic contact dermatitis)
  • Side effects
    Mild (dry mouth)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg Four times daily
Advice & Tips: Been taking Benadryl as a sleeping aid for years in conjunction with Tylenol after I had a NASTY experience with generic Ambien. Have gotten used to it, but really appreciated its effectiveness during my current bout with poison oak.
Cost: < $25 monthly

  • 0 helpful marks

Sep 16, 2016 (Started Jun 30, 2012)

  • Effectiveness
    Slight (for insomnia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg Daily

  • 0 helpful marks

Aug 21, 2016 (Started Jul 09, 2016)

  • Effectiveness
    Moderate (for insomnia)
  • Side effects
    Mild (dry mouth)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg Daily
Advice & Tips: I have taken it in conjunction with Acetominophen for many years (generic Tylenol PM), but recently confirmed its effectiveness and safety with my doctor.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 24 patient evaluations for Diphenhydramine