What is Diphenhydramine?

Category: Over the Counter Drugs

Most popular types: Benadryl Benadryl Allergy Nightime Sleepaid Show all

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Diphenhydramine is an antihistamine. It is used to relieve irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold. It may also be used to prevent and treat motion sickness, or to control abnormal movements in early stage parkinsonian syndrome.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Insomnia 249 105
Food allergy 223 22
Chronic idiopathic hives 101 5
Idiopathic angioedema 98 4
Anaphylaxis 68 12

Show all 173 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 19
Moderate 64
Mild 84
None 128

Commonly reported side effects and conditions associated with Diphenhydramine

Side effect Patients Percentage
Drowsiness 34
Sleepiness 20
Dry mouth 13
Excessive daytime sleepiness (somnolence) 8
Grogginess in morning 7
Brain fog 6

Show all 54 reported side effects

Dosages

Based on patients currently taking Diphenhydramine

Dosage Patients Percentage
25mg as needed 12
50 mg daily 9
25 mg daily 6
2 25mg as needed 5
50mg as needed 5
25 mg twice daily 3
75 mg daily 2
25 mg every other day 1
25 mg four times daily 1
150 mg daily 1

See all 17 dosages

Why patients stopped taking Diphenhydramine

Multiple reasons could be selected

Reason Patients Percentage
Other 74
Did not seem to work 50
Course of treatment ended 38
Doctor's advice 32
Side effects too severe 26
Personal research 11
Expense 5
Change in health plan coverage 1
See all 209 patients who've stopped taking Diphenhydramine

Duration

Currently taking Diphenhydramine

Duration Patients Percentage
1 - 6 months 1
6 months - 1 year 2
1 - 2 years 2
2 - 5 years 15
5 - 10 years 12
10 years or more 22

Stopped taking Diphenhydramine

Duration Patients Percentage
Less than 1 month 64
1 - 6 months 39
6 months - 1 year 27
1 - 2 years 20
2 - 5 years 27
5 - 10 years 8
10 years or more 25
Adherence
Adherence Evaluations Percentage
Always 179
Usually 67
Sometimes 36
Never taken as prescribed 13
Burden
Burden Evaluations Percentage
Very hard to take 4
Somewhat hard to take 16
A little hard to take 39
Not at all hard to take 236
Cost per month
Cost per month Evaluations Percentage
$200+ 1
$100-199 0
$50-99 1
$25-49 6
< $25 150
Not specified 137

What people switch to and from

Patients started taking Diphenhydramine after stopping:

Treatment Patients Percentage
Itraconazole (Sporanox) 1
Trazodone (Apo-Trazodone) 1
Zolpidem (Ambien) 1

Patients stopped taking Diphenhydramine and switched to:

Treatment Patients Percentage
Hydroxyzine (Vistaril) 4
Amitriptyline (Elavil) 1
Diphenhydramine (IV or IM) (Benadryl IV) 1
Eszopiclone (Lunesta) 1
Gabapentin (Neurontin) 1

Show all 11 treatments patients report switching to

Last updated:

23 patient evaluations for Diphenhydramine

Sep 22, 2016 (Started Sep 14, 2016)

  • Effectiveness
    Moderate (for allergic contact dermatitis)
  • Side effects
    Mild (dry mouth)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg Four times daily
Advice & Tips: Been taking Benadryl as a sleeping aid for years in conjunction with Tylenol after I had a NASTY experience with generic Ambien. Have gotten used to it, but really appreciated its effectiveness during my current bout with poison oak.
Cost: < $25 monthly

  • 0 helpful marks

Aug 21, 2016 (Started Jul 09, 2016)

  • Effectiveness
    Moderate (for insomnia)
  • Side effects
    Mild (dry mouth)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg Daily
Advice & Tips: I have taken it in conjunction with Acetominophen for many years (generic Tylenol PM), but recently confirmed its effectiveness and safety with my doctor.
Cost: < $25 monthly

  • 0 helpful marks

Mar 21, 2015 (Started Dec 04, 2009)

  • Effectiveness
    Moderate (for insomnia)
  • Side effects
    Moderate (dry mouth)
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: As needed

  • 0 helpful marks
Last updated:
Showing 3 of 23 patient evaluations for Diphenhydramine