What is Desvenlafaxine?

Category: Prescription Drugs

Most popular types: Pristiq Exsira

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Desvenlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI). It is an extended release formulation believed to treat depression by affecting the levels of serotonin and norepinephrine, two neurotransmitters associated with depression.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Depressed mood 265 175
Major depressive disorder 239 158
Anxious mood 117 93
Fibromyalgia 40 34
Bipolar disorder 24 12
Pain 11 9

Show all 53 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 54
Moderate 66
Mild 93
None 172

Commonly reported side effects and conditions associated with Desvenlafaxine

Side effect Patients Percentage
Decreased sex drive (libido) 15
Nausea 12
Weight gain 12
Dizziness 9
Dry mouth 8
Sedation 8

Show all 103 reported side effects

Dosages

Based on patients currently taking Desvenlafaxine

Dosage Patients Percentage
50 mg daily 17
100 mg daily 13
25 mg daily 6
200 mg daily 3
150 mg daily 2
300 mg daily 2
45 mg daily 1
50 mg twice daily 1
400 mg daily 1

Why patients stopped taking Desvenlafaxine

Multiple reasons could be selected

Reason Patients Percentage
Did not seem to work 92
Side effects too severe 62
Doctor's advice 44
Expense 42
Other 32
Change in health plan coverage 11
Course of treatment ended 7
Personal research 7
See all 212 patients who've stopped taking Desvenlafaxine

Duration

Currently taking Desvenlafaxine

Duration Patients Percentage
1 - 6 months 5
6 months - 1 year 8
1 - 2 years 8
2 - 5 years 13
5 - 10 years 10
10 years or more 3

Stopped taking Desvenlafaxine

Duration Patients Percentage
Less than 1 month 31
1 - 6 months 65
6 months - 1 year 43
1 - 2 years 39
2 - 5 years 28
5 - 10 years 7
10 years or more 1
Adherence
Adherence Evaluations Percentage
Always 327
Usually 39
Sometimes 3
Never taken as prescribed 16
Burden
Burden Evaluations Percentage
Very hard to take 14
Somewhat hard to take 27
A little hard to take 48
Not at all hard to take 296
Cost per month
Cost per month Evaluations Percentage
$200+ 7
$100-199 14
$50-99 40
$25-49 71
< $25 107
Not specified 146

What people switch to and from

Patients started taking Desvenlafaxine after stopping:

Treatment Patients Percentage
Venlafaxine (Effexor XR) 29
Duloxetine (Cymbalta) 19
Fluoxetine (Prozac) 16
Escitalopram (Lexapro) 15
Bupropion (Wellbutrin XL) 12

Show all 28 treatments patients report switching from

Patients stopped taking Desvenlafaxine and switched to:

Treatment Patients Percentage
Venlafaxine (Effexor XR) 10
Duloxetine (Cymbalta) 6
Fluoxetine (Prozac) 6
Vilazodone (Viibryd) 4
Vortioxetine (Trintellix) 4

Show all 23 treatments patients report switching to

Last updated:

28 patient evaluations for Desvenlafaxine

Feb 11, 2020 (Started Aug 07, 2017)

  • Effectiveness
    Major (for anxious mood)
  • Side effects
    Moderate (excessive sweating)
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: Not for all
Cost: $50-99 monthly

  • 0 helpful marks

Feb 7, 2020 (Started Feb 27, 2019)

  • Effectiveness
    Major (for major depressive disorder)
  • Side effects
    Mild (expressionless face (masklike))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 100 mg Daily
Advice & Tips: I switched from generic duloxetine to Pristiq. The generic manufacturer changed their process, or my brain changed?? One difference is that I needed more duloxetine in the winter dark months and that made me drowsy. I was also prescribed modafinil when I was working 9-5, so that I could concentrate and be alert. I don't need modafinil with Pristiq and I don't need to change the dosage according to the seasons. I feel more emotionally blunted with Pristiq, though. It took a few months to discover that duloxetine quit working, to find a replacement, and get back to a stable life. I miss the "duloxetine generic". It performed truer to the Cymbalta brand. It had the added benefit of easing the arthritis in my hands. I never knew this until they substituted manufactures of duloxetine.
Cost: < $25 monthly

  • 0 helpful marks

Jun 8, 2018 (Started Dec 19, 2017)

  • Effectiveness
    Moderate (for depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg Daily
Advice & Tips: Now taking 200mg pill. It is the target dosage. It seems to be working fine.
Cost: $25-49 monthly

Jan 23, 2018 (Started Dec 19, 2017)

  • Effectiveness
    Can't tell (for major depressive disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg Daily
Advice & Tips: Takes a while to work. hoping for the best.
Cost: $25-49 monthly

Dec 27, 2017 (Started Dec 19, 2017)

  • Effectiveness
    Major (for major depressive disorder)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 25 mg Daily
Advice & Tips: It takes awhile to start to work. My Dr. set me up on 25mg but I feel I should be on a stronger dosage. Will take that up with her at my next appointment.
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 28 patient evaluations for Desvenlafaxine