What is Dalfampridine?

Category: Prescription Drugs

Most popular types: Ampyra Fampyra

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Dalfampridine is an extended release formulation of 4-aminopyridine or 4-AP. It is a potassium channel blocker that is used as a treatment to improve walking in patients with multiple sclerosis (MS). Dalfampridine was previously called Fampridine-SR during clinical trials.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple sclerosis 2060 701
Walking problems 1914 568
Improve mobility 318 328
Fatigue 34 30
Improve flexibility/strength 34 38
Balance problems 28 36

Show all 48 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 56
Moderate 69
Mild 180
None 649

Commonly reported side effects and conditions associated with Dalfampridine

Side effect Patients Percentage
Insomnia 29
Dizziness 22
Nausea 17
Headaches 12
Constipation 11
Balance problems 10

Show all 106 reported side effects

Dosages

Based on patients currently taking Dalfampridine

Dosage Patients Percentage
10 mg twice daily 30
20 mg daily 14
10 mg daily 5
2 tablet(s) daily 4
1 tablet(s) twice daily 2
30 mg daily 2
1 twice daily 1
10 mg every other day 1
200 mg monthly 1
15 mg daily 1

See all 11 dosages

Why patients stopped taking Dalfampridine

Multiple reasons could be selected

Reason Patients Percentage
Did not seem to work 219
Side effects too severe 114
Other 70
Expense 54
Doctor's advice 52
Change in health plan coverage 18
Course of treatment ended 12
Personal research 9
See all 400 patients who've stopped taking Dalfampridine

Duration

Currently taking Dalfampridine

Duration Patients Percentage
6 months - 1 year 1
1 - 2 years 3
2 - 5 years 16
5 - 10 years 29
10 years or more 13

Stopped taking Dalfampridine

Duration Patients Percentage
Less than 1 month 87
1 - 6 months 113
6 months - 1 year 46
1 - 2 years 60
2 - 5 years 56
5 - 10 years 14
10 years or more 7
Adherence
Adherence Evaluations Percentage
Always 777
Usually 114
Sometimes 23
Never taken as prescribed 40
Burden
Burden Evaluations Percentage
Very hard to take 15
Somewhat hard to take 41
A little hard to take 105
Not at all hard to take 793
Cost per month
Cost per month Evaluations Percentage
$200+ 53
$100-199 55
$50-99 93
$25-49 247
< $25 257
Not specified 249

What people switch to and from

Patients started taking Dalfampridine after stopping:

Treatment Patients Percentage
Glatiramer acetate (Copaxone) 7
Fampridine (4-AP immediate release) 4
Dimethyl fumarate (Tecfidera) 2
Natalizumab (Tysabri) 2
Interferon beta-1a IM Injection (Avonex) 1

Show all 8 treatments patients report switching from

Patients stopped taking Dalfampridine and switched to:

Treatment Patients Percentage
Teriflunomide (Aubagio) 3
Dimethyl fumarate (Tecfidera) 2
Natalizumab (Tysabri) 2
Amifampridine phosphate (3,4 Diaminopyridine) 1
Cyclophosphamide (Cytoxan) 1

Show all 11 treatments patients report switching to

Last updated:

78 patient evaluations for Dalfampridine

Jan 23, 2020 (Started Jul 01, 2007)

  • Effectiveness
    Moderate (for walking problems)
  • Effectiveness
    None (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 10 mg Twice daily
Advice & Tips: Space doses at least 10 hours apart so as to avoid risk of seizures. Not a miracle drug, but if I miss it, I notice the increased difficulty walking very quickly.

  • 0 helpful marks

Oct 9, 2017 (Started Apr 21, 2014)

  • Effectiveness
    Can't tell (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: 20 mg Daily
Advice & Tips: it was discontinued 1 week after starting because of risk to liver.
Cost: < $25 monthly

  • 0 helpful marks

Jun 24, 2017 (Started Apr 15, 2012)

  • Effectiveness
    Can't tell (for walking problems)
  • Effectiveness
    None (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 tablet(s) Daily
Advice & Tips: Nothing new.
Cost: $100-199 monthly

Mar 28, 2017 (Started Apr 15, 2012)

  • Effectiveness
    Can't tell (for multiple sclerosis)
  • Effectiveness
    Can't tell (for walking problems)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 tablet(s) Daily
Advice & Tips: No problem adhering to schedule - one pill every 12 hours. I don't really feel the difference, but my DH and the walking test that I did after 1 year after beginning the treatmentshowed an improvement in speed.
Cost: < $25 monthly

Feb 26, 2015 (Started Apr 15, 2012)

  • Effectiveness
    Moderate (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 2 tablet(s) Daily
Advice & Tips: Easy to take - 2 pills, one morning, second 12 hours later. I walk somewhat faster. I walk more than a few meters with my rollator, otherwise with a stick. I only walk with no help in my house.
Cost: < $25 monthly

Jun 26, 2013 (Started Apr 15, 2012)

  • Effectiveness
    Major (for multiple sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 tablet(s) Daily
Advice & Tips: stick with it and stick to the schedule.
Cost: $100-199 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 78 patient evaluations for Dalfampridine