What is Carbidopa-Levodopa CR?

Category: Prescription Drugs

Most popular types: Sinemet CR Half Sinemet CR Carbilev Show all

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A controlled release preparation of carbidopa/levodopa formulated to release a lower, smoother dose of medication. It is sometimes taken last thing at night in order to maintain dopamine levels throughout sleep and into the morning.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 310 166
Stiffness/spasticity 36 16
Improve mobility 15 10
Insomnia 5 4
Slow movement (bradykinesia) 5 1

Show all 40 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 11
Moderate 29
Mild 38
None 120

Commonly reported side effects and conditions associated with Carbidopa-Levodopa CR

Side effect Patients Percentage
Jerky movements 13
Vivid dreams 9
Fatigue 8
Nausea 7
Amber colored urine 4
Back pain 4

Show all 40 reported side effects

Dosages

Based on patients currently taking Carbidopa-Levodopa CR

Dosage Patients Percentage
25-100 mg daily 6
50 mg-200 mg daily 6
50-200 mg daily 5
25 mg-100 mg daily 5
36.25-145 mg daily 1
25-100 mg twice daily 1
2 x 25-100 mg daily 1
25-100 mg four times daily 1
2 x 25-100 mg twice daily 1
50-200 mg twice daily 1

See all 17 dosages

Why patients stopped taking Carbidopa-Levodopa CR

Multiple reasons could be selected

Reason Patients Percentage
Doctor's advice 38
Did not seem to work 23
Other 20
Side effects too severe 13
Personal research 5
Course of treatment ended 3
Change in health plan coverage 1
Expense 1
See all 87 patients who've stopped taking Carbidopa-Levodopa CR

Duration

Currently taking Carbidopa-Levodopa CR

Duration Patients Percentage
1 - 6 months 2
6 months - 1 year 2
1 - 2 years 3
2 - 5 years 15
5 - 10 years 7
10 years or more 7

Stopped taking Carbidopa-Levodopa CR

Duration Patients Percentage
Less than 1 month 11
1 - 6 months 21
6 months - 1 year 6
1 - 2 years 17
2 - 5 years 18
5 - 10 years 11
10 years or more 5
Adherence
Adherence Evaluations Percentage
Always 142
Usually 39
Sometimes 7
Never taken as prescribed 10
Burden
Burden Evaluations Percentage
Very hard to take 7
Somewhat hard to take 17
A little hard to take 59
Not at all hard to take 115
Cost per month
Cost per month Evaluations Percentage
$200+ 4
$100-199 4
$50-99 6
$25-49 6
< $25 104
Not specified 74

What people switch to and from

Patients started taking Carbidopa-Levodopa CR after stopping:

Treatment Patients Percentage
Carbidopa-Levodopa (Sinemet) 11
Carbidopa-Entacapone-Levodopa (Stalevo) 3
Carbidopa Levodopa ER (Rytary XR) 3
Apomorphine (Apokyn) 1
Entacapone (Comtan) 1

Show all 7 treatments patients report switching from

Patients stopped taking Carbidopa-Levodopa CR and switched to:

Treatment Patients Percentage
Carbidopa-Levodopa (Sinemet) 9
Carbidopa Levodopa ER (Rytary XR) 3
Carbidopa-Entacapone-Levodopa (Stalevo) 2
Acetaminophen (Paracetamol) (Tylenol) 1
Apomorphine (Apokyn) 1

Show all 7 treatments patients report switching to

Last updated:

32 patient evaluations for Carbidopa-Levodopa CR

Apr 11, 2018 (Started Jan 01, 2006)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg-200 mg Daily
Advice & Tips: same as above
Cost: < $25 monthly

Nov 4, 2017 (Started Jan 01, 2006)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg-200 mg Daily
Cost: < $25 monthly

Aug 10, 2017 (Started Jan 01, 2006)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Moderate (breakthrough pain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg-200 mg Daily
Cost: < $25 monthly

May 25, 2017 (Started Jan 01, 2006)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Moderate (breakthrough pain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg-200 mg Daily
Advice & Tips: I have breakthrough pain at times, but twisting and curling does not happen until 1 to 2 weeks before the next injections. 1 tablet at bedtime.
Cost: < $25 monthly

Jan 17, 2017 (Started Jan 01, 2006)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg-200 mg Daily
Advice & Tips: No changes
Cost: < $25 monthly

Oct 10, 2016 (Started Jan 01, 2006)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (breakthrough pain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg-200 mg Daily
Advice & Tips: At times my legs and feet cramp and I use the tens unit during the night.
Cost: < $25 monthly

Sep 14, 2016 (Started Jan 01, 2006)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Mild (breakthrough pain)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg-200 mg Daily
Advice & Tips: No change
Cost: < $25 monthly

Jul 13, 2016 (Started Jan 01, 2006)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (breakthrough pain)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg-200 mg Daily
Advice & Tips: I have breakthrough pain at times, but twisting and curling does not happen until 1 to 2 weeks before the next injections.
Cost: < $25 monthly

Nov 18, 2015 (Started Jan 01, 2006)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Mild (breakthrough pain)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg-200 mg Daily
Advice & Tips: Get up and use Tens unit to help
Cost: < $25 monthly

Sep 16, 2015 (Started Jan 01, 2006)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg-200 mg Daily
Cost: < $25 monthly

Jul 15, 2015 (Started Jan 01, 2006)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg-200 mg Daily
Cost: < $25 monthly

  • 0 helpful marks

Aug 2, 2017 (Started May 15, 2017)

  • Effectiveness
    Moderate (for muscle spasms at night)
  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Mild (weight gain, exhausting dreams)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 200 mg Daily
Advice & Tips: Has been successful at controlling my wrestles legs. now they have doubled my dose. small tablets easy to take and now I am having a decent amount of sleep it makes the new day more bearable. Unfortunately have started acting out my dreams and being very vocal. Doesn't bother me but my poor husband has to listen to me (sometimes shouting) and he has a few bruises.
Cost: < $25 monthly

May 6, 2009 (Started May 15, 2017)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Effectiveness
    Slight (for muscle spasms at night)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take

  • 0 helpful marks

Jun 26, 2017 (Started Jul 17, 2011)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Advice & Tips: none
Cost: < $25 monthly

Mar 15, 2017 (Started Jul 17, 2011)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: 50 mg-200 mg Daily
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 32 patient evaluations for Carbidopa-Levodopa CR