What is Carbidopa-Levodopa?

Category: Prescription Drugs

Most popular types: Sinemet Carbidopa-Levodopa 25-100 Sinemet 25/100 Show all

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Levodopa is a dopamine precursor used to treat the movement disorder symptoms of Parkinson's disease. Carbidopa is often included with levodopa-containing drugs in order to boost its efficacy by slowing down the metabolism of dopamine.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 2990 2063
Stiffness/spasticity 112 89
Multiple system atrophy 88 64
Restless legs syndrome 87 71
Tremor(s) 63 59
Slow movement (bradykinesia) 55 37

Show all 88 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 97
Moderate 417
Mild 680
None 998

Commonly reported side effects and conditions associated with Carbidopa-Levodopa

Side effect Patients Percentage
Jerky movements 163
Nausea 153
Drowsiness 48
Constipation 34
Headaches 27
Dry mouth 22

Show all 288 reported side effects

Dosages

Based on patients currently taking Carbidopa-Levodopa

Dosage Patients Percentage
25-100 mg three times daily 38
25-100 mg four times daily 22
2 x 25-100 mg three times daily 15
3 x 25 mg-100 mg daily 13
25-100 mg five times daily 12
2 x 25-100 mg four times daily 12
25 mg-100 mg three times daily 9
1.5 x 25-100 mg three times daily 8
25-100 mg daily 7
4 x 25 mg-100 mg daily 6

See all 101 dosages

Why patients stopped taking Carbidopa-Levodopa

Multiple reasons could be selected

Reason Patients Percentage
Doctor's advice 138
Did not seem to work 110
Side effects too severe 97
Other 77
Personal research 30
Course of treatment ended 18
Change in health plan coverage 8
Expense 5
See all 395 patients who've stopped taking Carbidopa-Levodopa

Duration

Currently taking Carbidopa-Levodopa

Duration Patients Percentage
1 - 6 months 9
6 months - 1 year 17
1 - 2 years 24
2 - 5 years 97
5 - 10 years 94
10 years or more 58

Stopped taking Carbidopa-Levodopa

Duration Patients Percentage
Less than 1 month 49
1 - 6 months 86
6 months - 1 year 55
1 - 2 years 67
2 - 5 years 97
5 - 10 years 43
10 years or more 17
Adherence
Adherence Evaluations Percentage
Always 1605
Usually 458
Sometimes 54
Never taken as prescribed 75
Burden
Burden Evaluations Percentage
Very hard to take 74
Somewhat hard to take 334
A little hard to take 552
Not at all hard to take 1232
Cost per month
Cost per month Evaluations Percentage
$200+ 24
$100-199 28
$50-99 68
$25-49 186
< $25 1220
Not specified 666

What people switch to and from

Patients started taking Carbidopa-Levodopa after stopping:

Treatment Patients Percentage
Ropinirole (Requip) 52
Pramipexole (Mirapex) 44
Rasagiline (Azilect) 27
Amantadine (Symmetrel) 23
Carbidopa-Entacapone-Levodopa (Stalevo) 20

Show all 20 treatments patients report switching from

Patients stopped taking Carbidopa-Levodopa and switched to:

Treatment Patients Percentage
Carbidopa Levodopa ER (Rytary XR) 75
Carbidopa-Entacapone-Levodopa (Stalevo) 18
Ropinirole (Requip) 17
Carbidopa-Levodopa CR (Sinemet CR) 11
Pramipexole (Mirapex) 11

Show all 20 treatments patients report switching to

Last updated:

133 patient evaluations for Carbidopa-Levodopa

Jun 26, 2020 (Started Jun 30, 2004)

  • Effectiveness
    Moderate (for restless legs syndrome)
  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Moderate (tardive dyskinesia, headache, headaches)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 1 tablet(s) Four times daily
Cost: < $25 monthly

Mar 1, 2020 (Started Jun 30, 2004)

  • Effectiveness
    Major (for restless legs syndrome)
  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Moderate (tardive dyskinesia, headache, headaches)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 0.5 tablet(s) Daily
Advice & Tips: I have tardive dyskinesia very strongly now and it is even detectable to others around me. It is embarrassing to me. I am able to stop the dyskinesia for a few seconds at a time but it always returns. I guess I can just be thankful that it involves my legs, feet and my torso but NOT my tongue or mouth. I hope that it never gets to those areas. I would not be able to leave my house.
Cost: < $25 monthly

Jan 12, 2017 (Started Jun 30, 2004)

  • Effectiveness
    Major (for Parkinson's disease)
  • Effectiveness
    Major (for restless legs syndrome)
  • Side effects
    Mild (tardive dyskinesia, headache, headaches)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: I am so afraid of increasing my dose of carbidopa/levadopa that I still have not even tried it. I might be able to move better if I increased it but I fear the nausea, the dyskinesia, the near syncope. However, I have such back pain that it interferes with everythingI want to do. I can only walk for a short time before I am looking for a place to sit. That eliminates any tours, any walks in the woods. I used to enjoy walking. And I have gained a lot of weight from being sedentary.
Cost: < $25 monthly

Apr 24, 2016 (Started Jun 30, 2004)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Effectiveness
    Can't tell (for restless legs syndrome)
  • Side effects
    Mild (tardive dyskinesia, headache, headaches)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: The carbidopa/levodopa works the best for me to lessen the symptoms of PD. Other Rx drugs I tried didn't work as well or they worked well for symptoms but caused syncope or near syncope and left me feeling drained. It took many months to find the right med & the right dose. I do realize that carb/levo may cause tardive dyskinesia before it's over. But right now it is the best I can do & I want to enjoy it while I can. I can do quite a bit still . I owe that to the carb/levo.
Cost: < $25 monthly

Nov 26, 2015 (Started Jun 30, 2004)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Effectiveness
    Moderate (for restless legs syndrome)
  • Side effects
    Mild (headache, headaches)
  • Adherence
    Usually
  • Burden
    Very hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: My niece showed me how to set my iPhone clock to have a timer go off every day at 1pm to remind me to take my mid day dose of carb/levo & pramipexole. It works!!! It has worked. I have not missed a day since using the timer. I now am aware of "wearing off" of the meds. I never noticed it until a few months ago. At my last appt with Neurologist he increased my carb/levo to 1 1/2 TID. He said to increase gradually. I haven't increased just yet because I want to be firmly on the previous dose first which I am with this timer helping me. Soon I will try the new increase.
Cost: < $25 monthly

Jun 5, 2015 (Started Jun 30, 2004)

  • Effectiveness
    Major (for Parkinson's disease)
  • Effectiveness
    Can't tell (for restless legs syndrome)
  • Side effects
    Mild (headache, headaches)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: Now I am taking a new dose-1 TID-gradually titrating up from 1/2 TID. I still miss my noon dose although not as often. It is difficult remembering. I do notice the increase in dose is helping me stand up straighter longer & within about an hour of taking my dose. It is a pain in the neck to take 3 x a day but it improves my symptoms.
Cost: < $25 monthly

Feb 11, 2015 (Started Jun 30, 2004)

  • Effectiveness
    Major (for restless legs syndrome)
  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: I no longer am seeing any improvement. Maybe I have just gotten used to it & no longer notice it. Maybe it is time to increase again.
Cost: < $25 monthly

Nov 10, 2014 (Started Jun 30, 2004)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: This formula (immediate release) was given so I can see if I can get more carb/levo into me for better symptom control, but the problem with this formula is that I have a hard time remembering the noon dose. I am having an easier time remembering it now that I am retired, but I still forget sometimes. So far I MAY have experienced improvement in symptoms: I occasionally get relief from my back pain. I think the pain is caused by the postural changes with PD & anything I do to correct posture relieves the pain. This 1/2 pill taken 3x a day gives me more levo than I was getting with the CR 50/200 1/2 daily. Just that small amt more seems to have helped me stand up better which relieves the pain.
Cost: < $25 monthly

  • 1 helpful mark

Apr 27, 2020 (Started Aug 02, 2013)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Aug 15, 2018 (Started Aug 02, 2013)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25-100 mg Five times daily
Advice & Tips: On advice of my MDS I switched to Rytary to even out the on/off periods I took c/l 25/100 for 13 years and did well on it
Cost: < $25 monthly

Nov 4, 2015 (Started Aug 02, 2013)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 1 tablet(s) Four times daily

May 31, 2015 (Started Aug 02, 2013)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 1 tablet(s) Four times daily

  • 1 helpful mark

Jan 1, 2019 (Started Jun 07, 2006)

  • Effectiveness
    Can't tell (for Parkinson's disease)
  • Side effects
    Severe (jerky movements)
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: discussed problems with taking lowest possible dose and cut down to 2 tab 4 times a day which left me with a significant amount of off time with significantly increased slowness, bradykinesia, slowed thinking, abrupt onset in drooling and overall accompanied by severe depression,
Cost: < $25 monthly
Side effects: jerky movements

May 22, 2018 (Started Jun 07, 2006)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 200 mg Daily
Advice & Tips: all the same
Cost: < $25 monthly
Side effects: jerky movements

Dec 21, 2010 (Started Jun 07, 2006)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Cost: < $25 monthly
Side effects: jerky movements

May 1, 2010 (Started Jun 07, 2006)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 100 mg Daily
Advice & Tips: suddenly became more dyskinetic and realized it was important to cut back on amount
Cost: < $25 monthly
Side effects: jerky movements

Feb 18, 2009 (Started Jun 07, 2006)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 800 mg Daily
Cost: < $25 monthly
Side effects: jerky movements

Jan 17, 2009 (Started Jun 07, 2006)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: 800 mg Daily
Cost: < $25 monthly
Side effects: jerky movements

Aug 19, 2008 (Started Jun 07, 2006)

  • Effectiveness
    Major (for Other)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Sometimes
  • Burden
    A little hard to take
Dosage: 800 mg Daily
Advice & Tips: use exactly as directed to avoid side effects
Cost: < $25 monthly
Side effects: jerky movements

  • 1 helpful mark
Last updated:
Showing 3 of 133 patient evaluations for Carbidopa-Levodopa