What is Carbidopa-Levodopa?

Category: Prescription Drugs

Most popular types: Sinemet Carbidopa-Levodopa 25-100 Sinemet 25/100 Show all

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Levodopa is a dopamine precursor used to treat the movement disorder symptoms of Parkinson's disease. Carbidopa is often included with levodopa-containing drugs in order to boost its efficacy by slowing down the metabolism of dopamine.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 2940 1967
Stiffness/spasticity 112 87
Multiple system atrophy 88 59
Restless legs syndrome 84 66
Tremor(s) 63 59
Slow movement (bradykinesia) 55 37

Show all 87 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 94
Moderate 398
Mild 645
None 951

Commonly reported side effects and conditions associated with Carbidopa-Levodopa

Side effect Patients Percentage
Jerky movements 162
Nausea 145
Drowsiness 48
Constipation 33
Headaches 27
Dry mouth 21

Show all 282 reported side effects

Dosages

Based on patients currently taking Carbidopa-Levodopa

Dosage Patients Percentage
25-100 mg three times daily 47
2 x 25-100 mg three times daily 23
25-100 mg four times daily 21
3 x 25 mg-100 mg daily 17
25-100 mg five times daily 16
2 x 25-100 mg four times daily 15
1.5 x 25-100 mg three times daily 13
25 mg-100 mg three times daily 13
25 mg-100 mg daily 11
4 x 25 mg-100 mg daily 10

See all 143 dosages

Why patients stopped taking Carbidopa-Levodopa

Multiple reasons could be selected

Reason Patients Percentage
Doctor's advice 138
Did not seem to work 110
Side effects too severe 94
Other 77
Personal research 30
Course of treatment ended 18
Change in health plan coverage 7
Expense 5
See all 391 patients who've stopped taking Carbidopa-Levodopa

Duration

Currently taking Carbidopa-Levodopa

Duration Patients Percentage
1 - 6 months 3
6 months - 1 year 4
1 - 2 years 46
2 - 5 years 142
5 - 10 years 141
10 years or more 84

Stopped taking Carbidopa-Levodopa

Duration Patients Percentage
Less than 1 month 50
1 - 6 months 86
6 months - 1 year 54
1 - 2 years 65
2 - 5 years 96
5 - 10 years 42
10 years or more 16
Adherence
Adherence Evaluations Percentage
Always 1534
Usually 434
Sometimes 52
Never taken as prescribed 68
Burden
Burden Evaluations Percentage
Very hard to take 67
Somewhat hard to take 319
A little hard to take 525
Not at all hard to take 1177
Cost per month
Cost per month Evaluations Percentage
$200+ 22
$100-199 26
$50-99 66
$25-49 181
< $25 1158
Not specified 635

What people switch to and from

Patients started taking Carbidopa-Levodopa after stopping:

Treatment Patients Percentage
Ropinirole (Requip) 51
Pramipexole (Mirapex) 42
Rasagiline (Azilect) 26
Amantadine (Symmetrel) 23
Carbidopa-Entacapone-Levodopa (Stalevo) 20

Show all 19 treatments patients report switching from

Patients stopped taking Carbidopa-Levodopa and switched to:

Treatment Patients Percentage
Carbidopa Levodopa ER (Rytary XR) 71
Carbidopa-Entacapone-Levodopa (Stalevo) 17
Ropinirole (Requip) 17
Carbidopa-Levodopa CR (Sinemet CR) 11
Pramipexole (Mirapex) 10

Show all 20 treatments patients report switching to

Last updated:

133 patient evaluations for Carbidopa-Levodopa

Jan 1, 2019 (Started Jun 07, 2006)

  • Effectiveness
    Can't tell (for Parkinson's disease)
  • Side effects
    Severe (jerky movements)
  • Adherence
    Never taken as prescribed
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Advice & Tips: discussed problems with taking lowest possible dose and cut down to 2 tab 4 times a day which left me with a significant amount of off time with significantly increased slowness, bradykinesia, slowed thinking, abrupt onset in drooling and overall accompanied by severe depression,
Cost: < $25 monthly
Side effects: jerky movements

May 22, 2018 (Started Jun 07, 2006)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 200 mg Daily
Advice & Tips: all the same
Cost: < $25 monthly
Side effects: jerky movements

Dec 21, 2010 (Started Jun 07, 2006)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 200 mg Daily
Cost: < $25 monthly
Side effects: jerky movements

May 1, 2010 (Started Jun 07, 2006)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 100 mg Daily
Advice & Tips: suddenly became more dyskinetic and realized it was important to cut back on amount
Cost: < $25 monthly
Side effects: jerky movements

Feb 18, 2009 (Started Jun 07, 2006)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 800 mg Daily
Cost: < $25 monthly
Side effects: jerky movements

Jan 17, 2009 (Started Jun 07, 2006)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: 800 mg Daily
Cost: < $25 monthly
Side effects: jerky movements

Aug 19, 2008 (Started Jun 07, 2006)

  • Effectiveness
    Major (for Other)
  • Side effects
    Mild (jerky movements)
  • Adherence
    Sometimes
  • Burden
    A little hard to take
Dosage: 800 mg Daily
Advice & Tips: use exactly as directed to avoid side effects
Cost: < $25 monthly
Side effects: jerky movements

  • 1 helpful mark

Oct 28, 2018 (Started Aug 18, 2011)

  • Effectiveness
    Can't tell (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Jul 15, 2018 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Mar 22, 2017 (Started Aug 18, 2011)

  • Effectiveness
    Moderate (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Dec 9, 2016 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Jun 16, 2016 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Dec 22, 2015 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Nov 21, 2013 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Dec 6, 2012 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Sep 5, 2011 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

  • 0 helpful marks

Aug 15, 2018 (Started Aug 02, 2013)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25-100 mg Five times daily
Advice & Tips: On advice of my MDS I switched to Rytary to even out the on/off periods I took c/l 25/100 for 13 years and did well on it
Cost: < $25 monthly

Nov 4, 2015 (Started Aug 02, 2013)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 1 tablet(s) Four times daily

May 31, 2015 (Started Aug 02, 2013)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 1 tablet(s) Four times daily

  • 1 helpful mark
Last updated:
Showing 3 of 133 patient evaluations for Carbidopa-Levodopa