What is Carbidopa-Entacapone-Levodopa?

Category: Prescription Drugs

Most popular types: Stalevo Stalevo 100 Stalevo 150 Show all

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The combination of levodopa, carbidopa, and entacapone is used for Parkinson's Disease. Levodopa is the precursor to dopamine, carbidopa slows the breakdown of levodopa, while entacapone improves the efficacy of levodopa.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Parkinson's disease 637 302
Stiffness/spasticity 22 18
Increase effect of another treatment 15 14
Improve mobility 5 4
Slow movement (bradykinesia) 3 0
Tremor in hands 3 2

Show all 26 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 32
Moderate 71
Mild 79
None 133

Commonly reported side effects and conditions associated with Carbidopa-Entacapone-Levodopa

Side effect Patients Percentage
Jerky movements 36
Nausea 17
Cramps in legs 8
Dry mouth 7
Fatigue 6
Weight gain 6

Show all 89 reported side effects

Dosages

Based on patients currently taking Carbidopa-Entacapone-Levodopa

Dosage Patients Percentage
31.25-200-125 mg three times daily 2
37.5-200-150 mg three times daily 2
50-200-200 mg four times daily 2
4 x 25-200-100 mg four times daily 2
125 mg five times daily 2
12.5-200-50 mg three times daily 1
12.5-200-50 mg five times daily 1
3 x 31.25-200-125 mg daily 1
50-200-200 mg twice daily 1
25-200-100 mg five times daily 1

See all 24 dosages

Why patients stopped taking Carbidopa-Entacapone-Levodopa

Multiple reasons could be selected

Reason Patients Percentage
Side effects too severe 71
Doctor's advice 66
Did not seem to work 40
Other 35
Expense 21
Personal research 8
Change in health plan coverage 3
Course of treatment ended 1
See all 195 patients who've stopped taking Carbidopa-Entacapone-Levodopa

Duration

Currently taking Carbidopa-Entacapone-Levodopa

Duration Patients Percentage
1 - 6 months 1
6 months - 1 year 1
1 - 2 years 3
2 - 5 years 8
5 - 10 years 10
10 years or more 7

Stopped taking Carbidopa-Entacapone-Levodopa

Duration Patients Percentage
Less than 1 month 28
1 - 6 months 57
6 months - 1 year 37
1 - 2 years 22
2 - 5 years 47
5 - 10 years 14
10 years or more 6
Adherence
Adherence Evaluations Percentage
Always 236
Usually 60
Sometimes 7
Never taken as prescribed 12
Burden
Burden Evaluations Percentage
Very hard to take 17
Somewhat hard to take 33
A little hard to take 65
Not at all hard to take 200
Cost per month
Cost per month Evaluations Percentage
$200+ 19
$100-199 16
$50-99 29
$25-49 45
< $25 99
Not specified 107

What people switch to and from

Patients started taking Carbidopa-Entacapone-Levodopa after stopping:

Treatment Patients Percentage
Carbidopa-Levodopa (Sinemet) 36
Ropinirole (Requip) 7
Carbidopa Levodopa ER (Rytary XR) 3
Amantadine (Symmetrel) 2
Carbidopa-Entacapone-Levodopa (Stalevo) 2

Show all 12 treatments patients report switching from

Patients stopped taking Carbidopa-Entacapone-Levodopa and switched to:

Treatment Patients Percentage
Carbidopa-Levodopa (Sinemet) 14
Carbidopa Levodopa ER (Rytary XR) 10
Entacapone (Comtan) 5
Carbidopa-Entacapone-Levodopa (Stalevo) 2
Carbidopa-Levodopa CR (Sinemet CR) 2

Show all 11 treatments patients report switching to

Last updated:

42 patient evaluations for Carbidopa-Entacapone-Levodopa

Mar 26, 2018 (Started Jan 10, 2011)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50-200-200 mg Three times daily
Advice & Tips: I take the kind that dissolves in your mouth, because of my emphysema. I take it three times a day at 8am 3pm and 10pm. That works well for me.
Cost: < $25 monthly

Jun 8, 2016 (Started Jan 10, 2011)

  • Effectiveness
    Major (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 50-200-200 mg Three times daily
Cost: < $25 monthly

  • 0 helpful marks

Jun 19, 2017 (Started Jul 01, 2011)

  • Effectiveness
    Slight (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 12.5-200-50 mg Three times daily

  • 0 helpful marks

Jun 13, 2017 (Started May 19, 2017)

  • Effectiveness
    None (for Parkinson's disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: I have advanced pd. We were hoping it might help me a little bit more than Rytary. It didn't.
Cost: $200+ monthly

Sep 16, 2015 (Started May 19, 2017)

  • Effectiveness
    Can't tell (for Parkinson's disease)
  • Effectiveness
    Can't tell (for stiffness/spasticity)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: I HAVE BEEN GOING BACK AND FORTH BETWEEN STALEVO AND RYTARY. UNFORTUNATELY, NEITHER SEEM TO BE HELPNG ME.
Cost: $200+ monthly

Apr 13, 2015 (Started May 19, 2017)

  • Effectiveness
    Can't tell (for Parkinson's disease)
  • Effectiveness
    Can't tell (for stiffness/spasticity)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: I STOPPED STALEVO TO GO ON RYTARY--THE NEW DRUG. I DON'T FEEL LIKE IT HELPED ME AT ALL
Cost: $200+ monthly

  • 0 helpful marks
Last updated:
Showing 3 of 42 patient evaluations for Carbidopa-Entacapone-Levodopa