What is Diphenhydramine?

Category: Over the Counter Drugs

Most popular types: Benadryl Benadryl Allergy Nightime Sleepaid Show all

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Diphenhydramine is an antihistamine. It is used to relieve irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold. It may also be used to prevent and treat motion sickness, or to control abnormal movements in early stage parkinsonian syndrome.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Insomnia 247 105
Food allergy 222 22
Idiopathic angioedema 103 4
Chronic idiopathic hives 102 5
Anaphylaxis 69 12

Show all 174 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 19
Moderate 65
Mild 84
None 130

Commonly reported side effects and conditions associated with Diphenhydramine

Side effect Patients Percentage
Drowsiness 34
Sleepiness 20
Dry mouth 13
Excessive daytime sleepiness (somnolence) 8
Grogginess in morning 7
Brain fog 6

Show all 54 reported side effects

Dosages

Based on patients currently taking Diphenhydramine

Dosage Patients Percentage
50 mg daily 8
25mg as needed 6
50mg as needed 6
2 25mg as needed 5
25 mg twice daily 2
75 mg daily 2
as needed 2
25 mg weekly 1
25 mg daily 1
25 mg four times daily 1

See all 17 dosages

Why patients stopped taking Diphenhydramine

Multiple reasons could be selected

Reason Patients Percentage
Other 74
Did not seem to work 49
Course of treatment ended 39
Doctor's advice 32
Side effects too severe 26
Personal research 11
Expense 5
Change in health plan coverage 1
See all 209 patients who've stopped taking Diphenhydramine

Duration

Currently taking Diphenhydramine

Duration Patients Percentage
1 - 2 years 1
2 - 5 years 10
5 - 10 years 14
10 years or more 20

Stopped taking Diphenhydramine

Duration Patients Percentage
Less than 1 month 63
1 - 6 months 40
6 months - 1 year 27
1 - 2 years 20
2 - 5 years 26
5 - 10 years 9
10 years or more 25
Adherence
Adherence Evaluations Percentage
Always 180
Usually 68
Sometimes 37
Never taken as prescribed 13
Burden
Burden Evaluations Percentage
Very hard to take 4
Somewhat hard to take 16
A little hard to take 40
Not at all hard to take 238
Cost per month
Cost per month Evaluations Percentage
$200+ 1
$100-199 0
$50-99 1
$25-49 6
< $25 150
Not specified 140

What people switch to and from

Patients started taking Diphenhydramine after stopping:

Treatment Patients Percentage
Zolpidem (Ambien) 2
Itraconazole (Sporanox) 1
Trazodone (Apo-Trazodone) 1

Patients stopped taking Diphenhydramine and switched to:

Treatment Patients Percentage
Hydroxyzine (Vistaril) 4
Amitriptyline (Elavil) 1
Diphenhydramine (IV or IM) (Benadryl IV) 1
Eszopiclone (Lunesta) 1
Gabapentin (Neurontin) 1

Show all 11 treatments patients report switching to

Last updated:

23 patient evaluations for Diphenhydramine

Sep 22, 2016 (Started Sep 14, 2016)

  • Effectiveness
    Moderate (for allergic contact dermatitis)
  • Side effects
    Mild (dry mouth)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg Four times daily
Advice & Tips: Been taking Benadryl as a sleeping aid for years in conjunction with Tylenol after I had a NASTY experience with generic Ambien. Have gotten used to it, but really appreciated its effectiveness during my current bout with poison oak.
Cost: < $25 monthly

  • 0 helpful marks

Aug 21, 2016 (Started Jul 09, 2016)

  • Effectiveness
    Moderate (for insomnia)
  • Side effects
    Mild (dry mouth)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg Daily
Advice & Tips: I have taken it in conjunction with Acetominophen for many years (generic Tylenol PM), but recently confirmed its effectiveness and safety with my doctor.
Cost: < $25 monthly

  • 0 helpful marks

Mar 21, 2015 (Started Dec 04, 2009)

  • Effectiveness
    Moderate (for insomnia)
  • Side effects
    Moderate (dry mouth)
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: As needed

  • 0 helpful marks
Last updated:
Showing 3 of 23 patient evaluations for Diphenhydramine