What is Diphenhydramine?

Category: Over the Counter Drugs

Most popular types: Benadryl Benadryl Allergy Simply Sleep Show all

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Diphenhydramine is an antihistamine. It is used to relieve irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold. It may also be used to prevent and treat motion sickness, or to control abnormal movements in early stage parkinsonian syndrome.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Insomnia 208 95
Food allergy 58 22
Itching 36 14
Anaphylaxis 26 9
Chemical/venom allergy 12 5

Show all 146 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 19
Moderate 60
Mild 75
None 116

Commonly reported side effects and conditions associated with Diphenhydramine

Side effect Patients Percentage
Drowsiness 34
Sleepiness 19
Dry mouth 12
Excessive daytime sleepiness (somnolence) 8
Grogginess in morning 7
Brain fog 6

Show all 51 reported side effects

Dosages

Based on patients currently taking Diphenhydramine

Dosage Patients Percentage
25mg as needed 21
50 mg daily 13
25 mg daily 11
2 25mg as needed 11
50mg as needed 8
50 mg twice daily 4
25 mg twice daily 3
50 mg every other week 2
75 mg daily 2
12.5mg as needed 2

See all 24 dosages

Why patients stopped taking Diphenhydramine

Multiple reasons could be selected

Reason Patients Percentage
Other 66
Did not seem to work 49
Course of treatment ended 36
Doctor's advice 30
Side effects too severe 23
Personal research 11
Expense 4
Change in health plan coverage 1
See all 194 patients who've stopped taking Diphenhydramine

Duration

Currently taking Diphenhydramine

Duration Patients Percentage
Less than 1 month 1
1 - 6 months 3
6 months - 1 year 7
1 - 2 years 11
2 - 5 years 19
5 - 10 years 16
10 years or more 36

Stopped taking Diphenhydramine

Duration Patients Percentage
Less than 1 month 64
1 - 6 months 38
6 months - 1 year 28
1 - 2 years 19
2 - 5 years 23
5 - 10 years 10
10 years or more 23
Adherence
Adherence Evaluations Percentage
Always 160
Usually 63
Sometimes 36
Never taken as prescribed 11
Burden
Burden Evaluations Percentage
Very hard to take 4
Somewhat hard to take 16
A little hard to take 36
Not at all hard to take 214
Cost per month
Cost per month Evaluations Percentage
$200+ 1
$100-199 0
$50-99 1
$25-49 6
< $25 138
Not specified 124

What people switch to and from

Patients started taking Diphenhydramine after stopping:

Treatment Patients Percentage
Trazodone (Desyrel) 1
Zolpidem (Ambien) 1

Patients stopped taking Diphenhydramine and switched to:

Treatment Patients Percentage
Hydroxyzine (Vistaril) 4
Diphenhydramine (IV or IM) (Benadryl IV) 1
Meclizine (Meclizine OTC) 1
Quetiapine (Seroquel) 1
Trazodone (Desyrel) 1
Last updated:

23 patient evaluations for Diphenhydramine

Sep 22, 2016 (Started Sep 14, 2016)

  • Effectiveness
    Moderate (for allergic contact dermatitis)
  • Side effects
    Mild (dry mouth)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg Four times daily
Advice & Tips: Been taking Benadryl as a sleeping aid for years in conjunction with Tylenol after I had a NASTY experience with generic Ambien. Have gotten used to it, but really appreciated its effectiveness during my current bout with poison oak.
Cost: < $25 monthly

  • 0 helpful marks

Aug 21, 2016 (Started Jul 09, 2016)

  • Effectiveness
    Moderate (for insomnia)
  • Side effects
    Mild (dry mouth)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 50 mg Daily
Advice & Tips: I have taken it in conjunction with Acetominophen for many years (generic Tylenol PM), but recently confirmed its effectiveness and safety with my doctor.
Cost: < $25 monthly

  • 0 helpful marks

Mar 21, 2015 (Started Dec 04, 2009)

  • Effectiveness
    Moderate (for insomnia)
  • Side effects
    Moderate (dry mouth)
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: As needed

  • 0 helpful marks
Last updated:
Showing 3 of 23 patient evaluations for Diphenhydramine