What is Azathioprine?

Category: Prescription Drugs

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Azathioprine is an immunosuppressant agent used to manage active rheumatoid arthritis and as an adjunctive therapy for the prevention of rejection of kidney transplants.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Systemic lupus erythematosus 206 92
Prevent organ rejection 126 31
Crohn's disease 120 55
Neuromyelitis optica 58 18
Idiopathic pulmonary fibrosis 53 25

Show all 132 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 68
Moderate 85
Mild 79
None 143

Commonly reported side effects and conditions associated with Azathioprine

Side effect Patients Percentage
Nausea 34
Hair loss 23
Fatigue 18
Vomiting 10
Elevated liver enzymes 9
Diarrhea 7

Show all 143 reported side effects

Dosages

Based on patients currently taking Azathioprine

Dosage Patients Percentage
50 mg daily 16
150 mg daily 9
75 mg daily 7
100 mg daily 7
50 mg twice daily 6
50 mg three times daily 5
200 mg daily 5
100 mg twice daily 3
25 mg daily 2
125 mg daily 2

See all 17 dosages

Why patients stopped taking Azathioprine

Multiple reasons could be selected

Reason Patients Percentage
Doctor's advice 124
Side effects too severe 119
Did not seem to work 85
Other 49
Course of treatment ended 29
Personal research 12
Change in health plan coverage 7
Expense 3
See all 318 patients who've stopped taking Azathioprine

Duration

Currently taking Azathioprine

Duration Patients Percentage
1 - 6 months 3
6 months - 1 year 4
1 - 2 years 9
2 - 5 years 22
5 - 10 years 17
10 years or more 15

Stopped taking Azathioprine

Duration Patients Percentage
Less than 1 month 60
1 - 6 months 70
6 months - 1 year 44
1 - 2 years 53
2 - 5 years 40
5 - 10 years 27
10 years or more 27
Adherence
Adherence Evaluations Percentage
Always 312
Usually 29
Sometimes 9
Never taken as prescribed 25
Burden
Burden Evaluations Percentage
Very hard to take 16
Somewhat hard to take 18
A little hard to take 66
Not at all hard to take 275
Cost per month
Cost per month Evaluations Percentage
$200+ 4
$100-199 3
$50-99 8
$25-49 14
< $25 161
Not specified 185

What people switch to and from

Patients started taking Azathioprine after stopping:

Treatment Patients Percentage
Methotrexate (Trexall) 39
Prednisone (Deltasone) 18
Hydroxychloroquine (Plaquenil) 12
Mycophenolate mofetil (CellCept) 12
Mesalamine (Pentasa) 8

Show all 31 treatments patients report switching from

Patients stopped taking Azathioprine and switched to:

Treatment Patients Percentage
Mycophenolate mofetil (CellCept) 18
Methotrexate (Trexall) 15
Adalimumab (Humira) 5
Hydroxychloroquine (Plaquenil) 5
Leflunomide (Arava) 5

Show all 28 treatments patients report switching to

Last updated:

15 patient evaluations for Azathioprine

Nov 15, 2013 (Started Mar 13, 2013)

  • Effectiveness
    Slight (for chronic diarrhea)
  • Effectiveness
    Slight (for systemic lupus erythematosus)
  • Side effects
    Moderate
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 75 mg Daily
Advice & Tips: Always listen to your body, if it's aching or sore somewhere, thee is usually a reason for it. Follow up on it and don't let it go.

  • 0 helpful marks

Aug 29, 2013 (Started Sep 06, 1974)

  • Effectiveness
    Major (for transplant rejection prevention)
  • Effectiveness
    Major (for Prevent organ rejection)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 100 mg Daily
Cost: < $25 monthly

Sep 14, 2011 (Started Sep 06, 1974)

  • Effectiveness
    Major (for Prevent organ rejection)
  • Effectiveness
    Major (for transplant rejection prevention)
  • Side effects
    Severe (non-Hodgkin's lymphoma)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 100 mg Daily
Advice & Tips: This treatment had virtually no negative impact on me, with the exception of developing post-transplant lymphoproliferative disorder (lymphoma) over thirty years later. That nearly killed me, but five years passed and I am declared cured, and 37 years after my transplant, my kidney still works well.
Cost: < $25 monthly

Sep 13, 2010 (Started Sep 06, 1974)

  • Effectiveness
    Major (for transplant rejection prevention)
  • Side effects
    Severe (non-Hodgkin's lymphoma)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 100 mg Daily
Advice & Tips: Taking two or three pills for life off of dialysis is a no-brainer. I developed lymphoma as a result of the azathioprine, but the chances of getting this are greater for the newer medications. I was initially worried about infections from this med but it has not been much of a problem.
Cost: < $25 monthly

  • 0 helpful marks

Jun 13, 2013 (Started Mar 18, 2009)

  • Effectiveness
    Major (for Prevent organ rejection)
  • Effectiveness
    Major (for transplant rejection prevention)
  • Side effects
    Mild (loss of balance, night cramps in legs and feet)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg Daily
Cost: $25-49 monthly
Side effects: night cramps in legs and feet

  • 0 helpful marks
Last updated:
Showing 3 of 15 patient evaluations for Azathioprine