What is Azathioprine?

Category: Prescription Drugs

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Azathioprine is an immunosuppressant agent used to manage active rheumatoid arthritis and as an adjunctive therapy for the prevention of rejection of kidney transplants.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Systemic lupus erythematosus 1989 94
Crohn's disease 657 55
Idiopathic pulmonary fibrosis 265 25
Prevent organ rejection 241 31
Ulcerative colitis 163 24
Autoimmune hepatitis 149 15

Show all 143 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 73
Moderate 87
Mild 79
None 148

Commonly reported side effects and conditions associated with Azathioprine

Side effect Patients Percentage
Nausea 34
Hair loss 23
Fatigue 18
Vomiting 10
Elevated liver enzymes 9
Diarrhea 8

Show all 147 reported side effects

Dosages

Based on patients currently taking Azathioprine

Dosage Patients Percentage
50 mg twice daily 7
50 mg daily 4
100 mg daily 2
150 mg daily 2
50 mg three times daily 2
50 mg m,w,f 1
25 mg daily 1
75 mg daily 1
200 mg daily 1
250 mg daily 1

See all 11 dosages

Why patients stopped taking Azathioprine

Multiple reasons could be selected

Reason Patients Percentage
Doctor's advice 133
Side effects too severe 124
Did not seem to work 93
Other 53
Course of treatment ended 30
Personal research 12
Change in health plan coverage 8
Expense 4
See all 339 patients who've stopped taking Azathioprine

Duration

Currently taking Azathioprine

Duration Patients Percentage
1 - 6 months 2
6 months - 1 year 2
1 - 2 years 1
2 - 5 years 12
5 - 10 years 5
10 years or more 5

Stopped taking Azathioprine

Duration Patients Percentage
Less than 1 month 61
1 - 6 months 70
6 months - 1 year 44
1 - 2 years 52
2 - 5 years 42
5 - 10 years 27
10 years or more 27
Adherence
Adherence Evaluations Percentage
Always 321
Usually 29
Sometimes 10
Never taken as prescribed 27
Burden
Burden Evaluations Percentage
Very hard to take 18
Somewhat hard to take 19
A little hard to take 67
Not at all hard to take 283
Cost per month
Cost per month Evaluations Percentage
$200+ 4
$100-199 3
$50-99 8
$25-49 15
< $25 165
Not specified 192

What people switch to and from

Patients started taking Azathioprine after stopping:

Treatment Patients Percentage
Methotrexate (Apo-Methotrexate) 43
Prednisone (Prednisone Intensol) 22
Hydroxychloroquine (Plaquenil) 17
Mycophenolate mofetil (CellCept) 14
Mesalamine (Pentasa) 9

Show all 33 treatments patients report switching from

Patients stopped taking Azathioprine and switched to:

Treatment Patients Percentage
Mycophenolate mofetil (CellCept) 34
Methotrexate (Apo-Methotrexate) 16
Adalimumab (Humira) 10
Hydroxychloroquine (Plaquenil) 10
Belimumab (Benlysta) 7

Show all 35 treatments patients report switching to

Last updated:

15 patient evaluations for Azathioprine

Nov 15, 2013 (Started Mar 13, 2013)

  • Effectiveness
    Slight (for chronic diarrhea)
  • Effectiveness
    Slight (for systemic lupus erythematosus)
  • Side effects
    Moderate
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 75 mg Daily
Advice & Tips: Always listen to your body, if it's aching or sore somewhere, thee is usually a reason for it. Follow up on it and don't let it go.

  • 0 helpful marks

Aug 29, 2013 (Started Sep 06, 1974)

  • Effectiveness
    Major (for transplant rejection prevention)
  • Effectiveness
    Major (for Prevent organ rejection)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 100 mg Daily
Cost: < $25 monthly

Sep 14, 2011 (Started Sep 06, 1974)

  • Effectiveness
    Major (for Prevent organ rejection)
  • Effectiveness
    Major (for transplant rejection prevention)
  • Side effects
    Severe (non-Hodgkin's lymphoma)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 100 mg Daily
Advice & Tips: This treatment had virtually no negative impact on me, with the exception of developing post-transplant lymphoproliferative disorder (lymphoma) over thirty years later. That nearly killed me, but five years passed and I am declared cured, and 37 years after my transplant, my kidney still works well.
Cost: < $25 monthly

Sep 13, 2010 (Started Sep 06, 1974)

  • Effectiveness
    Major (for transplant rejection prevention)
  • Side effects
    Severe (non-Hodgkin's lymphoma)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 100 mg Daily
Advice & Tips: Taking two or three pills for life off of dialysis is a no-brainer. I developed lymphoma as a result of the azathioprine, but the chances of getting this are greater for the newer medications. I was initially worried about infections from this med but it has not been much of a problem.
Cost: < $25 monthly

  • 0 helpful marks

Jun 13, 2013 (Started Mar 18, 2009)

  • Effectiveness
    Major (for Prevent organ rejection)
  • Effectiveness
    Major (for transplant rejection prevention)
  • Side effects
    Mild (loss of balance, night cramps in legs and feet)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 50 mg Daily
Cost: $25-49 monthly
Side effects: night cramps in legs and feet

  • 0 helpful marks
Last updated:
Showing 3 of 15 patient evaluations for Azathioprine