129 patient evaluations for Carbidopa-Levodopa

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garden35
37670 thumb
garden35
Sex: M
Data Quality: 3 stars
On
Mouth/throat: none
Arms: none
Chest: none
Legs: none
I am: vg
I have:
Parkinson's

See garden35's full Carbidopa-Levodopa history

Mar 22, 2017 (Started Aug 18, 2011)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Dec 9, 2016 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Jun 16, 2016 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Dec 22, 2015 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Nov 21, 2013 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Dec 6, 2012 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

Sep 5, 2011 (Started Aug 18, 2011)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: < $25 monthly

  • 0 helpful marks
J.Marley
20395 thumb
J.Marley
Sex: M
Data Quality: 3 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: n
I have:
Parkinson's

See J.Marley's full Carbidopa-Levodopa history

Feb 3, 2017 (Started Jun 21, 2010)

  • Effectiveness
    Moderate (for Tremor in hands)
  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Mild (Jerky movements (dyskinesia), Nausea and vomiting, Occasional nausea and vomiting)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: $25-49 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

Nov 28, 2016 (Started Jun 21, 2010)

  • Effectiveness
    Moderate (for Tremor in hands)
  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Mild (Jerky movements (dyskinesia), Nausea and vomiting, Occasional nausea and vomiting)
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 3 x 25 mg-100 mg Daily
Cost: $25-49 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

Dec 15, 2015 (Started Jun 21, 2010)

  • Effectiveness
    Moderate (for Tremor in hands)
  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Mild (Jerky movements (dyskinesia), Nausea and vomiting, Occasional nausea and vomiting)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 x 25 mg-100 mg Daily
Advice & Tips: This summer I had to lower my total intake of carbidopa / levodopa as I began to experience dyskinesia in the evenings.  If I keep my daily levodopa dose at or below 1200 mgs, I seldom experience any dyskinesia.
Cost: $25-49 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

Dec 17, 2012 (Started Jun 21, 2010)

  • Effectiveness
    Moderate (for Tremor in hands)
  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Advice & Tips: I take the regular Sinemet pill as a 'back-up' to my extended release Sinemet when I go to the gym, paint or do something during which time I hope to lesson my tremors - it does seem to help.
Cost: < $25 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

Jul 6, 2010 (Started Jun 21, 2010)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    Mild (Nausea and vomiting, Occasional nausea and vomiting)
  • Adherence
    Usually
  • Burden
    A little hard to take
Cost: $25-49 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

Jun 30, 2010 (Started Jun 21, 2010)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    Mild (Nausea and vomiting, Occasional nausea and vomiting)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: $25-49 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

Jun 29, 2010 (Started Jun 21, 2010)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    Mild (Nausea and vomiting, Occasional nausea and vomiting)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Cost: $25-49 monthly
Side effects: Nausea and vomiting, Occasional nausea and vomiting

  • 0 helpful marks
margie99
70573 thumb
margie99
Sex: F
Data Quality: 3 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: g
I have:
Parkinson's

See margie99's full Carbidopa-Levodopa history

Jan 17, 2017 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Effectiveness
    Moderate (for Dystonia)
  • Side effects
    Mild (Nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: I eat crackers before taking the medication so I don't vomit.
Cost: < $25 monthly

Oct 10, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Effectiveness
    Slight (for Dystonia)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25 mg-100 mg Daily
Cost: < $25 monthly

Sep 14, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Effectiveness
    Slight (for Dystonia)
  • Side effects
    Mild (Nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: crackers help
Cost: < $25 monthly

Jul 13, 2016 (Started Jul 01, 2011)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Effectiveness
    Slight (for Dystonia)
  • Side effects
    Moderate (Nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Daily
Advice & Tips: I continue to be nausea, but crackers help.
Cost: < $25 monthly

  • 0 helpful marks
StrkL
16679 thumb
StrkL
Sex: M
Data Quality: 3 stars
On
Mouth/throat: mild
Arms: none
Chest: none
Legs: mild
I am: g
I have:
Parkinson's

See StrkL's full Carbidopa-Levodopa history

Jan 15, 2017 (Started Jun 12, 2007)

  • Effectiveness
    Major (for Walking difficult without aid)
  • Effectiveness
    Major (for Tremor in hands)
  • Effectiveness
    Major (for Stiffness/Spasticity)
  • Effectiveness
    Major (for Slowness (bradykinesia))
  • Effectiveness
    Major (for Parkinson's Disease)
  • Effectiveness
    Major (for Mobility decreased)
  • Effectiveness
    Moderate (for Loss of balance)
  • Effectiveness
    Moderate (for Balance problems)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 6 x 25 mg-100 mg Daily
Advice & Tips: As of January 2017 I have stopped taking sinemet because I had DBS.
Cost: < $25 monthly
Side effects: Jerky movements (dyskinesia), Drowsiness

May 11, 2014 (Started Jun 12, 2007)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Jerky movements (dyskinesia), Drowsiness)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 6 x 25 mg-100 mg Daily
Advice & Tips: As of today, I am still taking six sinemet daily, two pills at a time. Even when I am off, I can write and type almost as well as ever. And even when off, I have no tremor (unless I try to walk, then my right hand shakes.) And when I am on, my walking is generally normal. (I sometimes have problems with freezing when on.) My balance is also much better when I'm on. When off, I have difficulty standing on one leg, but I can do so for a minute or more when on.
Cost: < $25 monthly
Side effects: Jerky movements (dyskinesia), Drowsiness

Sep 19, 2010 (Started Jun 12, 2007)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Jerky movements (dyskinesia), Drowsiness)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 6 x 25 mg-100 mg Daily
Advice & Tips: At my most recent neurologist visit, she told me I had dyskinesias. My wife has also noticed them. I'm not sure how long I"ve had them, probably a few months. At my previous visit, three months ago (when I saw the Nurse Practitioner, not the neurologist), the Nurse did not mention them. They are quite mild - at least mild enough that I don't notice. My neurologist has suggested I take more Amantadine to see if this reduces them.
Cost: < $25 monthly
Side effects: Jerky movements (dyskinesia), Drowsiness

Mar 29, 2009 (Started Jun 12, 2007)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Drowsiness)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 6 x 25 mg-100 mg Daily
Advice & Tips: The first neurologist I saw, in March 2006, had me try a couple of sinemet per day. They had absolutely no effect. The second neurologist I saw, in April 2007, had me take a half tablet per day for the first week, one tablet daily the second, one and a half daily the third, and so on until I was taking four daily after eight weeks. It had no effect until the fifth week, when I started taking two and a half tablets daily. At that time, it improved my eating, dressing, and showering, but did not improve my writing or typing or walking. Later in 2007 I went to five sinemet daily, with little change. During the summer of 2008 I went to six, and my writing and typing essentially became normal. Even when off I’m able to write and type almost as well as ever. And I have no tremor. My walking improved dramatically as well – I could walk a mile or more first thing in the morning after taking my medication. But I would be off a substantial part of the day. I was taking one pill at 5 AM, 9 AM, noon, 3 PM, 6 PM, and 9 PM. In the fall of 2008 I went to taking two pills at 5 AM, 8 AM, and 1 PM. This improved my walking considerably.
Cost: < $25 monthly
Side effects: Jerky movements (dyskinesia), Drowsiness

  • 0 helpful marks
reikihh
6571 thumb
reikihh
Sex: F
Data Quality: 3 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: n
I have:
Parkinson's

See reikihh's full Carbidopa-Levodopa history

Jan 12, 2017 (Started Jun 30, 2004)

  • Effectiveness
    Major (for RLS (Restless Legs Syndrome))
  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Headaches, headache)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: I am so afraid of increasing my dose of carbidopa/levadopa that I still have not even tried it. I might be able to move better if I increased it but I fear the nausea, the dyskinesia, the near syncope. However, I have such back pain that it interferes with everythingI want to do. I can only walk for a short time before I am looking for a place to sit. That eliminates any tours, any walks in the woods. I used to enjoy walking. And I have gained a lot of weight from being sedentary.
Cost: < $25 monthly

Apr 24, 2016 (Started Jun 30, 2004)

  • Effectiveness
    Can’t tell (for RLS (Restless Legs Syndrome))
  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Mild (Headaches, headache)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: The carbidopa/levodopa works the best for me to lessen the symptoms of PD. Other Rx drugs I tried didn't work as well or they worked well for symptoms but caused syncope or near syncope and left me feeling drained. It took many months to find the right med & the right dose. I do realize that carb/levo may cause tardive dyskinesia before it's over. But right now it is the best I can do & I want to enjoy it while I can. I can do quite a bit still . I owe that to the carb/levo.
Cost: < $25 monthly

Nov 26, 2015 (Started Jun 30, 2004)

  • Effectiveness
    Moderate (for RLS (Restless Legs Syndrome))
  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Mild (Headaches, headache)
  • Adherence
    Usually
  • Burden
    Very hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: My niece showed me how to set my iPhone clock to have a timer go off every day at 1pm to remind me to take my mid day dose of carb/levo & pramipexole. It works!!! It has worked. I have not missed a day since using the timer. I now am aware of "wearing off" of the meds. I never noticed it until a few months ago. At my last appt with Neurologist he increased my carb/levo to 1 1/2 TID. He said to increase gradually. I haven't increased just yet because I want to be firmly on the previous dose first which I am with this timer helping me. Soon I will try the new increase.
Cost: < $25 monthly

Jun 5, 2015 (Started Jun 30, 2004)

  • Effectiveness
    Can’t tell (for RLS (Restless Legs Syndrome))
  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Headaches, headache)
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: Now I am taking a new dose-1 TID-gradually titrating up from 1/2 TID. I still miss my noon dose although not as often. It is difficult remembering. I do notice the increase in dose is helping me stand up straighter longer & within about an hour of taking my dose. It is a pain in the neck to take 3 x a day but it improves my symptoms.
Cost: < $25 monthly

Feb 11, 2015 (Started Jun 30, 2004)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Effectiveness
    Major (for RLS (Restless Legs Syndrome))
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: I no longer am seeing any improvement. Maybe I have just gotten used to it & no longer notice it. Maybe it is time to increase again.
Cost: < $25 monthly

Nov 10, 2014 (Started Jun 30, 2004)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 25 mg-100 mg Three times daily
Advice & Tips: This formula (immediate release) was given so I can see if I can get more carb/levo into me for better symptom control, but the problem with this formula is that I have a hard time remembering the noon dose. I am having an easier time remembering it now that I am retired, but I still forget sometimes. So far I MAY have experienced improvement in symptoms: I occasionally get relief from my back pain. I think the pain is caused by the postural changes with PD & anything I do to correct posture relieves the pain. This 1/2 pill taken 3x a day gives me more levo than I was getting with the CR 50/200 1/2 daily. Just that small amt more seems to have helped me stand up better which relieves the pain.
Cost: < $25 monthly

  • 0 helpful marks
TamiLynn
775 thumb
TamiLynn
Sex: F
Data Quality: 2 stars
Off
Mouth/throat: none
Arms: mild
Chest: none
Legs: mild
I am: vg
I have:
Parkinson's

See TamiLynn's full Carbidopa-Levodopa history

Jan 3, 2017 (Started Jun 23, 2006)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Jerky movements (dyskinesia))
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 6 mg Daily
Cost: $100-199 monthly

  • 0 helpful marks
egaspar
42051 thumb
egaspar
Sex: F
Data Quality: 2 stars
On
Mouth/throat: none
Arms: none
Chest: none
Legs: mild
I am: g
I have:
Parkinson's

See egaspar's full Carbidopa-Levodopa history

Jan 3, 2017 (Started Mar 01, 2012)

  • Effectiveness
    Moderate (for Tremor in hands)
  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Moderate (Heartburn, Nausea during and after eating)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 6 x 25-100 mg Daily
Advice & Tips: when I first started this treatment the doctor prescribed Levadopa 25mg to balance out the nausea . It really seem to work well . I've since been taken off the additional Levadopa since my insurance will not cover it . If your insurance will cover it then I would advise asking about the Levadopa 25mg to go with the carbadopa/levadopa 100/25mg if you have nausea .
Cost: $50-99 monthly

  • 0 helpful marks
Napiejoe
30221 thumb
Napiejoe
Sex: M
Data Quality: 2 stars
On
Mouth/throat: mild
Arms: mild
Chest: none
Legs: mild
I am: g
I have:
Parkinson's

See Napiejoe's full Carbidopa-Levodopa history

Nov 10, 2016 (Started Jan 20, 2009)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Jerky movements (dyskinesia))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 25-250 mg Five times daily
Cost: $25-49 monthly

May 26, 2015 (Started Jan 20, 2009)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Moderate (Jerky movements (dyskinesia))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4 x 25 mg-250 mg Daily
Cost: < $25 monthly

May 19, 2013 (Started Jan 20, 2009)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Jerky movements (dyskinesia))
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 4 x 25 mg-100 mg Daily
Advice & Tips: I use a talking alarm watch to help me take my medication on time.
Cost: < $25 monthly

May 24, 2009 (Started Jan 20, 2009)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2 x 25 mg-100 mg Daily
Advice & Tips: Take your pills on time
Cost: $25-49 monthly

  • 0 helpful marks
Tulabee
14440 thumb
Tulabee
Sex: F
Data Quality: 3 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: g
I have:
Parkinson's

See Tulabee's full Carbidopa-Levodopa history

Sep 23, 2016 (Started Jul 27, 2011)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Jerky movements (dyskinesia))
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Advice & Tips: Have stopped this and have been on Rytary since about August 2015
Cost: < $25 monthly
Side effects: Jerky movements (dyskinesia)

Oct 15, 2015 (Started Jul 27, 2011)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Jerky movements (dyskinesia))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: As needed
Advice & Tips: Rytary is better. It gives me a much smoother delivery.
Cost: < $25 monthly
Side effects: Jerky movements (dyskinesia)

Feb 1, 2015 (Started Jul 27, 2011)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Jerky movements (dyskinesia))
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: As needed
Advice & Tips: On the average, it is best to take 0.75 tablet every 4.00 to 4.25 hrs. If I am doing something physical like a long walk or if I have to keep moving my whole body for 2-3 hours, then 1.00 tablet. Do not do this if sitting at a desk-dyskinesia.
Cost: < $25 monthly
Side effects: Jerky movements (dyskinesia)

Nov 8, 2014 (Started Jul 27, 2011)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Moderate (Jerky movements (dyskinesia))
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: As needed
Advice & Tips: It's the fall/winter season, and I made a med change. IT coincides with the daylight getting shorter. About mid-to late Sept I increase the Cymbalta(depression) from 60mg to 120mg. This seems to affect how the L-dopa is metabolized. For a few weeks I was taking 1 whole tablet (100/25), every 5-6 hrs. The 0.75 dose wasn't doing its work. I also start on modafinil for alertness. Due to Rx screw up I wasn't able to start in Oct, but had to start in Nov. I was maintaining, but now I feel better with the modafinil. Like someone turning up the TV brightness switch just a little bit. But now I think I am very sensitive to the amount of L-dopa. I will work it out.
Cost: < $25 monthly
Side effects: Jerky movements (dyskinesia)

Apr 18, 2013 (Started Jul 27, 2011)

  • Effectiveness
    Moderate (for Parkinson's Disease)
  • Side effects
    Moderate (Jerky movements (dyskinesia))
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: As needed
Advice & Tips: This survey doesn't account for the way i take L-dopa. I started out at 1 tablet every 6 hours. Now I am at 0.75 tablet every 4 hours. So this means i am taking a smaller dose at more frequent intervals as Parkinson's progresses. If I take more than needed, the dyskinesia starts. If I go too long without a dose (usually sitting at work or computer), forget to take it, hand tremor starts.
Cost: < $25 monthly
Side effects: Jerky movements (dyskinesia)

  • 0 helpful marks
MossyRock
56174 thumb
MossyRock
Sex: M
Data Quality: 1 star
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: vg
I have:
Parkinson's

See MossyRock's full Carbidopa-Levodopa history

Jun 11, 2016 (Started Sep 15, 2010)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Moderate (Muscle and joint pain, Nausea and vomiting)
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 12 x 25-100 mg Five times daily
Advice & Tips: During a month long stay in hospital I did not have a problem with the nausea and vomiting.
Cost: $25-49 monthly

Jun 30, 2013 (Started Sep 15, 2010)

  • Effectiveness
    Major (for Parkinson's Disease)
  • Side effects
    Mild (Nausea and vomiting)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4 x 25 mg-100 mg Daily
Advice & Tips: In spite of the recommendation of taking the pills an hour before eating, I take it with food.
Cost: $25-49 monthly

  • 0 helpful marks
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Showing 10 of 129 patient evaluations for Carbidopa-Levodopa