I was DX'D 5/3/03 with ON in left eye which completely blinded me even after completing 5 days IVSM and the oral pack. I stayed blinded completely in the left eye for four years. After the brain MRI on 6/11/03 I was DX'D with RRMS. My brain was covered in lesions, and a couple in my c-spine. 6 months later I got a 2nd bout of ON in my right eye this time. After completeing IVSM and the oral pack my vision returned to almost normal within a week or two. During the first 4 years I was having flares atleast every months. Suffering from: numbness,electric shocks, headaches, spasity,tremors/seizure activity, gait,brain fog,bladder dysfuntion,swallowing issues,cognitive disfunction,depression, and wide spread pain. I went thru Copaxone, Betaserone and then was put on Novantrone. It finally slowed things down. I went into what I consider is a somewhat steady remission for a year and half. I did still have temporary flares which would come back, but they didnt last long and as soon as they came they soon left. I still kept spasity, muscle and joint pains, and headaches as residual symptoms. But up until September of this year things were going well. But I at this point my Neurologist DX'D me now with SPMS. Needless to say I have taken my lifetime maxium of Novantrone so with that not being an option anymore, so we decided to give Rebif a try, because as of now my insurance won't cover, or I can't get enough assistance to go on the Tysabri my Neurologist wants me on. So starting next week I will have finally titrated up to the full dose. So I am not sure how well I am responding...I did have a nasty exhasterbation after two shot of it...but who knows if it was from the medication or that it was just going to happen anyways. This MonSter is a rollor coaster ride...and I guess I am just along for the ride. We will just have to wait and see where this journey leads me.