I was diagnosed with Lupus SLE in 2009, and went through 5 years of turmoil. Plaquenil made everything WORSE. I can prove it; my Lupus levels have far exceeded any level I previously had (ANA is currently 58), yet I feel no pain. I have fatigue, which is debilitating at times, and swollen lymph nodes (biopsied to conclude it is all Lupus), and chronic headaches, but all of this is SO manageable compared to when I was on Plaquenil. I urge all of you to really be proactive about your health and diagnosis and don't just take Plaquenil because it is suggested or advised. For some, it must work, but for me, it was my downfall, and led to chronic pain, years of painkillers, sleep aids, steroids, and muscle relaxers. The bottom line, from my experience with 10 rheumies, autoimmune ailments like Lupus confound even the medical profession, and they are quick to state every symptom is Lupus if they don't have a definitive answer. It's your body. Take care of it. I have found that eating well, cutting out sugar and gluten (75%), and exercising regularly really helps. It's really hard for people who don't have Lupus to understand what you feel - flu-like some days, fatigued, achy, joint pain... but you would never have been given anything you cannot handle so don't lose hope. Hope doesn't breed eternal misery.... hope floats and makes the air and your surroundings less suffocating.