What is Low Dose Naltrexone (LDN)?

Category: Prescription Drugs

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Generic Name: Naltrexone

Naltrexone is FDA approved for alcohol and opioid dependence at 50mg doses. Pilot and preliminary studies of its use in low doses suggest there may be some positive effect for certain conditions.

Purpose
Patients
Patients with evaluations
Perceived effectiveness

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects of Low Dose Naltrexone (LDN)

Severe
19
Moderate
25
Mild
67
None
255

Commonly reported side effects, conditions, and hospitalizations associated with Low Dose Naltrexone (LDN)

Patients
20
Patients
10
Patients
9
Patients
8
Patients
6
Patients
5

Show all 102 reported side effects

Dosages

Most common dosages (by patients currently taking Low Dose Naltrexone (LDN))
Dosage
4.5 mg daily
Patients
307
Dosage
3 mg daily
Patients
148
Dosage
1.5 mg daily
Patients
40
Dosage
4 mg daily
Patients
37
Dosage
1 mg daily
Patients
23
Dosage
3.5 mg daily
Patients
23
Dosage
2 mg daily
Patients
12
Dosage
5 mg daily
Patients
9
Dosage
2.5 mg daily
Patients
7
Dosage
daily
Patients
6

Dosages based on patients currently taking Low Dose Naltrexone (LDN).

Why Patients Stopped Taking Low Dose Naltrexone (LDN) (multiple reasons could be selected)
Reason
Did not seem to work
Patients
98
Reason
Other
Patients
53
Reason
Side effects too severe
Patients
36
Reason
Doctor's advice
Patients
27
Reason
Expense
Patients
11
Reason
Personal research
Patients
8
Reason
Not indicated
Patients
6
Reason
Course of treatment ended
Patients
4
Reason
Change in health plan coverage
Patients
3
See all 191 patients who’ve stopped taking Low Dose Naltrexone (LDN)

Duration

Currently Taking Low Dose Naltrexone (LDN)
Duration
Patients
Duration
0-1 month
Patients
3
Duration
1-3 months
Patients
7
Duration
3-6 months
Patients
7
Duration
6 months-1 year
Patients
8
Duration
1-2 years
Patients
13
Duration
2 years or more
Patients
97
Stopped Taking Low Dose Naltrexone (LDN)
Duration
Patients
Duration
0-1 month
Patients
17
Duration
1-3 months
Patients
32
Duration
3-6 months
Patients
35
Duration
6 months-1 year
Patients
24
Duration
1-2 years
Patients
50
Duration
2 years or more
Patients
30

Adherence


Always
Patients
317
87%
Usually
Patients
35
10%
Sometimes
Patients
7
2%
Never
Patients
7
2%

Burden


Very
Patients
5
1%
Somewhat
Patients
16
4%
A little
Patients
33
9%
Not at all
Patients
312
85%

Cost per month


Cost per month
$200+
Patients
39
12%
Cost per month
$100-199
Patients
0
0%
Cost per month
$50-99
Patients
2
1%
Cost per month
$25-49
Patients
40
12%
Cost per month
< $25
Patients
176
54%
Cost per month
Not specified
Patients
109
33%

What people switch to and from

Patients started taking Low Dose Naltrexone (LDN) after stopping:
Treatment name(s)
Hydrocodone-Acetaminophen (Vicodin, Norco, Vicodin ES…)
Patients
2
Treatment name(s)
Pregabalin (Lyrica, Maxgalin, Provelyn)
Patients
2
Treatment name(s)
Amitriptyline (Elavil, Endep, Trepiline…)
Patients
1
Treatment name(s)
Donepezil (Aricept, Aricept ODT)
Patients
1
Treatment name(s)
Doxepin (Sinequan, Silenor, Deptran…)
Patients
1

See all 14 treatments patients report switching from

Patients stopped taking Low Dose Naltrexone (LDN) and switched to:
Treatment name(s)
Dimethyl fumarate (Tecfidera)
Patients
1
Treatment name(s)
Valacyclovir (Valtrex)
Patients
1
Last updated:

66 patient evaluations for Low Dose Naltrexone (LDN)

Kaessa
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Kaessa
Gender: F
Data Quality: 3 stars
Pain: None
Fatigue: Most
Sleep: Some
Stiffness: Little
function: All
external_stress: Some
Stickman: some
Description:F50y
FM:6y Dx
CFS:6y Dx
I am: b
I have:
Fibromyalgia

See Kaessa's full Low Dose Naltrexone (LDN) history

May 31, 2015 (Started Dec 01, 2014)

  • Perceived effectiveness for Fibromyalgia: Major
  • Side Effects: None
  • Adherence: Always
  • Burden: Not at all
Dosage: 4.5 mg Daily
Advice & Tips: Holy crap this stuff is a miracle drug. I went from barely being able to get out of bed for six years to going back to work full time. This is amazing.
Cost: < $25 monthly

  • 0 helpful marks
nusha
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nusha
Sex: F
Data Quality: 1 star
Relapse: Moderate
Sensation: None
Overall: None
Cognition: none
Vision: none
Speech: none
Swallowing: none
Upper limb: none
Walking: moderate
I am: g
I have:
MS

See nusha's full Low Dose Naltrexone (LDN) history

Apr 14, 2015 (Started Oct 11, 2013)

  • Perceived effectiveness for Multiple Sclerosis: None
  • Side Effects: None
  • Adherence: Always
  • Burden: Not at all
Dosage: 3 mg Daily
Advice & Tips: i am not taking LDN anymore, stopped in 2014 as I was seeing no benefit.

  • 0 helpful marks
gummitarzan
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gummitarzan
Data Quality: 3 stars
  • Gender: M
  • Age: 68
Condition: Rheumatoid Arthritis (RA) 5 additional condition(s)
Quality of Life:
  • Mental: Mild
  • Physical: Mild
I am: n
I have:
Rheumatoid Arthritis (RA)

See gummitarzan's full Low Dose Naltrexone (LDN) history

Mar 10, 2015 (Started Jan 31, 2015)

  • Perceived effectiveness for Rheumatoid Arthritis (RA): Can’t tell
  • Side Effects: None
  • Adherence: Usually
  • Burden: A little
Dosage: 1.5 mg Daily
Advice & Tips: First I had a positive effect, but after approx 25 days I felt bad again. So I take a reading break to find out what I did wrong.
Cost: Not specified monthly

  • 0 helpful marks
Last updated:
Showing 3 of 66 patient evaluations for Low Dose Naltrexone (LDN)