What is Low Dose Naltrexone (LDN)?

Category: Prescription Drugs

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Generic Name: Naltrexone

Naltrexone is FDA approved for alcohol and opioid dependence at 50mg doses. Pilot and preliminary studies of its use in low doses suggest there may be some positive effect for certain conditions.

Reported purpose & perceived effectiveness
Purpose Patients Patients with evaluations Perceived Effectiveness
398 184
103 65
95 48
33 16
31 16
31 21

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

side_effects of Low Dose Naltrexone (LDN)"

Severe
19
Moderate
25
Mild
69
None
250

Commonly reported side effects, conditions, and hospitalizations associated with Low Dose Naltrexone (LDN)

20
10
9
8
6
5

Show all 102 reported side effects

Dosages

Most common dosages (by patients currently taking Low Dose Naltrexone (LDN))
Dosage Patients
4.5 mg daily 301
3 mg daily 149
1.5 mg daily 38
4 mg daily 36
1 mg daily 23
3.5 mg daily 23
2 mg daily 11
5 mg daily 9
2.5 mg daily 7
daily 6

Dosages based on patients currently taking Low Dose Naltrexone (LDN).

Why Patients Stopped Taking Low Dose Naltrexone (LDN) (multiple reasons could be selected)
Reason Patients
Did not seem to work 97
Other 54
Side effects too severe 36
Doctor's advice 27
Personal research 9
Expense 9
Course of treatment ended 5
Not indicated 5
Change in health plan coverage 3
See all 189 patients who’ve stopped taking Low Dose Naltrexone (LDN)

Duration

Currently Taking Low Dose Naltrexone (LDN)
Duration Patients
0-1 month 2
1-3 months 3
3-6 months 6
6 months-1 year 8
1-2 years 20
2 years or more 107
Stopped Taking Low Dose Naltrexone (LDN)
Duration Patients
0-1 month 17
1-3 months 32
3-6 months 35
6 months-1 year 24
1-2 years 49
2 years or more 31
Adherence
Always
315 87%
Usually
35 10%
Sometimes
6 2%
Never
7 2%
Burden
Very
5 1%
Somewhat
17 5%
A little
33 9%
Not at all
308 85%
Cost per month
$200+
0 0%
$100-199
2 1%
$50-99
40 12%
$25-49
175 54%
107 33%

What people switch to and from

Patients started taking Low Dose Naltrexone (LDN) after stopping:
Treatment name(s) Patients
Donepezil (Aricept, Aricept ODT) 1
Doxepin (Sinequan, Silenor, Deptran…) 1
Gabapentin (Neurontin, Ratio-Gabapentin, Gabatin…) 1
Hydrocodone-Acetaminophen (Vicodin, Norco, Vicodin ES…) 1
Oxycodone (Oxycodone IR, Roxicodone, Oxycodone ER…) 1

See all 11 treatments patients report switching from

Patients stopped taking Low Dose Naltrexone (LDN) and switched to:
Treatment name(s) Patients
Dimethyl fumarate (Tecfidera) 1
Valacyclovir (Valtrex) 1
Last updated:

65 patient evaluations for Low Dose Naltrexone (LDN)

Kaessa
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Kaessa
Gender: F
Data Quality: 3 stars
Pain: Little
Fatigue: Little
Sleep: Little
Stiffness: Little
function: All
external_stress: Little
Stickman: little
Description:F50y
FM:6y Dx
CFS:6y Dx
I am: g
I have:
Fibromyalgia

See Kaessa's full Low Dose Naltrexone (LDN) history

May 31, 2015 (Started Dec 01, 2014)

  • Perceived effectiveness for Fibromyalgia: Major
  • Side Effects: None
  • Adherence: Always
  • Burden: Not at all
Dosage: 4.5 mg Daily
Advice & Tips: Holy crap this stuff is a miracle drug. I went from barely being able to get out of bed for six years to going back to work full time. This is amazing.
Cost: $25-49 monthly

  • 0 helpful marks
nusha
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nusha
Sex: F
Data Quality: 1 star
Relapse: Moderate
Sensation: None
Overall: None
Cognition: none
Vision: none
Speech: none
Swallowing: none
Upper limb: none
Walking: moderate
I am: g
I have:
MS

See nusha's full Low Dose Naltrexone (LDN) history

Apr 14, 2015 (Started Oct 11, 2013)

  • Perceived effectiveness for Multiple Sclerosis: None
  • Side Effects: None
  • Adherence: Always
  • Burden: Not at all
Dosage: 3 mg Daily
Advice & Tips: i am not taking LDN anymore, stopped in 2014 as I was seeing no benefit.

  • 0 helpful marks
gummitarzan
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gummitarzan
Data Quality: 3 stars
  • Gender: M
  • Age: 68
Condition: Rheumatoid Arthritis (RA) 5 additional condition(s)
Quality of Life:
  • Mental: Mild
  • Physical: Mild
I am: g
I have:
Rheumatoid Arthritis (RA)

See gummitarzan's full Low Dose Naltrexone (LDN) history

Mar 10, 2015 (Started Jan 31, 2015)

  • Perceived effectiveness for Rheumatoid Arthritis (RA): Can’t tell
  • Side Effects: None
  • Adherence: Usually
  • Burden: A little
Dosage: 1.5 mg Daily
Advice & Tips: First I had a positive effect, but after approx 25 days I felt bad again. So I take a reading break to find out what I did wrong.
Cost: < $25 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 65 patient evaluations for Low Dose Naltrexone (LDN)