What is Low Dose Naltrexone (LDN)?

Category: Prescription Drugs

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Generic Name: Naltrexone

Naltrexone is FDA approved for alcohol and opioid dependence at 50mg doses. Pilot and preliminary studies of its use in low doses suggest there may be some positive effect for certain conditions.

Reported purpose & perceived effectiveness

Purpose
Patients
Patients with evaluations
Perceived effectiveness

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects of Low Dose Naltrexone (LDN)

Severe
20
Moderate
27
Mild
67
None
268

Commonly reported side effects, conditions, and hospitalizations associated with Low Dose Naltrexone (LDN)

Patients
21
Patients
10
Patients
10
Patients
8
Patients
6
Patients
6

Show all 103 reported side effects

Dosages

Most common dosages (by patients currently taking Low Dose Naltrexone (LDN))
Dosage
4.5 mg daily
Patients
319
Dosage
3 mg daily
Patients
153
Dosage
1.5 mg daily
Patients
38
Dosage
4 mg daily
Patients
38
Dosage
3.5 mg daily
Patients
25
Dosage
1 mg daily
Patients
23
Dosage
2 mg daily
Patients
13
Dosage
5 mg daily
Patients
12
Dosage
2.5 mg daily
Patients
8
Dosage
daily
Patients
6

Dosages based on patients currently taking Low Dose Naltrexone (LDN).

Why Patients Stopped Taking Low Dose Naltrexone (LDN) (multiple reasons could be selected)
Reason
Did not seem to work
Patients
99
Reason
Other
Patients
52
Reason
Side effects too severe
Patients
35
Reason
Doctor's advice
Patients
28
Reason
Expense
Patients
11
Reason
Personal research
Patients
8
Reason
Not indicated
Patients
7
Reason
Course of treatment ended
Patients
4
Reason
Change in health plan coverage
Patients
1
See all 192 patients who’ve stopped taking Low Dose Naltrexone (LDN)

Duration

Currently Taking Low Dose Naltrexone (LDN)
Duration
Patients
Duration
0-1 month
Patients
1
Duration
1-3 months
Patients
4
Duration
3-6 months
Patients
7
Duration
6 months-1 year
Patients
18
Duration
1-2 years
Patients
15
Duration
2 years or more
Patients
168
Stopped Taking Low Dose Naltrexone (LDN)
Duration
Patients
Duration
0-1 month
Patients
17
Duration
1-3 months
Patients
32
Duration
3-6 months
Patients
35
Duration
6 months-1 year
Patients
23
Duration
1-2 years
Patients
50
Duration
2 years or more
Patients
31

Adherence


Always
Patients
330
86%
Usually
Patients
37
10%
Sometimes
Patients
6
2%
Never taken as prescribed
Patients
9
2%

Burden


Very hard to take
Patients
6
2%
Somewhat hard to take
Patients
17
4%
A little hard to take
Patients
34
9%
Not at all hard to take
Patients
325
85%

Cost per month


Cost per month
$200+
Patients
0
0%
Cost per month
$100-199
Patients
2
1%
Cost per month
$50-99
Patients
42
11%
Cost per month
$25-49
Patients
186
49%
Cost per month
< $25
Patients
110
29%
Cost per month
Not specified
Patients
42
11%

What people switch to and from

Patients started taking Low Dose Naltrexone (LDN) after stopping:
Treatment name(s)
Gabapentin (Neurontin, Gabatin, Ratio-Gabapentin…)
Patients
3
Treatment name(s)
Pregabalin (Lyrica, Maxgalin, Provelyn)
Patients
3
Treatment name(s)
Amitriptyline (Elavil, Endep, Trepiline…)
Patients
2
Treatment name(s)
Hydrocodone-Acetaminophen (Vicodin, Norco, Lortab…)
Patients
2
Treatment name(s)
Dalfampridine (Ampyra, Fampyra)
Patients
1

See all 24 treatments patients report switching from

Patients stopped taking Low Dose Naltrexone (LDN) and switched to:
Treatment name(s)
Alemtuzumab (Lemtrada, Campath)
Patients
1
Treatment name(s)
Dimethyl fumarate (Tecfidera)
Patients
1
Treatment name(s)
Valacyclovir (Valtrex)
Patients
1
Last updated:

69 patient evaluations for Low Dose Naltrexone (LDN)

woofhound
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woofhound
Gender: M
Data Quality: 3 stars
Pain: Some
Fatigue: Some
Sleep: All
Stiffness: Most
function: Some
external_stress: Little
Stickman: most
Description:M58y
CFS:10y Dx
FM:16y Dx
I am: n
I have:
Fibromyalgia

See woofhound's full Low Dose Naltrexone (LDN) history

Oct 1, 2015 (Started Aug 24, 2015)

  • Effectiveness
    Moderate (for Fibromyalgia)
  • Effectiveness
    Moderate (for Fatigue)
  • Side Effects
    None
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 5 mg Daily
Advice & Tips: I make my own solution by dissolving pill in distilled water and take it in daily portions. This is a bit of a pain, but much easier than paying for a compounding pharmacy.

  • 0 helpful marks
grandmajudy
32100 thumb
grandmajudy
Sex: F
Data Quality: 2 stars
On
Mouth/throat: moderate
Arms: mild
Chest: moderate
Legs: mild
I am: g
I have:
Parkinson's

See grandmajudy's full Low Dose Naltrexone (LDN) history

Sep 13, 2015 (Started Oct 30, 2009)

  • Effectiveness
    Major (for to stop imbalance,helps decrease rigidity in arms legs and neck)
  • Side Effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Advice & Tips: I am still on LDN and i still am having positive results on my Right side.
Cost: $25-49 monthly

Dec 12, 2011 (Started Oct 30, 2009)

  • Effectiveness
    Major (for to stop imbalance,helps decrease rigidity in arms legs and neck)
  • Side Effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Advice & Tips: I have been on LDN since November 2009/ Since I have been on LDn my right side and neck is no longer rigid. I do have rigidity in my left arm and pain in my elbow. On November 11 2011 My Neurologist gave me Botox injections in my left shoulder and elbow and inner arm. It has helped with the pain and I can move my arm more freely. I almost have no pain.
Cost: < $25 monthly

Mar 26, 2011 (Started Oct 30, 2009)

  • Effectiveness
    Major (for to stop imbalance,helps decrease rigidity in arms legs and neck)
  • Side Effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Advice & Tips: I have been on LDN since November 2009. I have no more rigidity in my neck or right side. Still have some in my left arm. Am not falling as often. I also have more energy then I had when I was not on it. I did stop LDN for about 3 weeks in November 2010 the rigidity came back in my my neck and right side and my left arm got worse. I noticed that my balance had gotten much worse too. Since I restarted the LDN in December 2010 I am back to the way I was feeling before I stopped taking it. I will not go a day with out LDN because this is the only medication that has helped me . I have not experienced any side affects like I did with all of the other medications that I have been on for my Parkinsonism.
Cost: < $25 monthly

  • 3 helpful marks
Kaessa
14639 thumb
Kaessa
Gender: F
Data Quality: 3 stars
Pain: Little
Fatigue: All
Sleep: Most
Stiffness: Little
function: Some
external_stress: Some
Stickman: some
Description:F51y
CFS:6y Dx
FM:7y Dx
I am: g
I have:
Fibromyalgia

See Kaessa's full Low Dose Naltrexone (LDN) history

May 31, 2015 (Started Dec 01, 2014)

  • Effectiveness
    Major (for Fibromyalgia)
  • Side Effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Advice & Tips: Holy crap this stuff is a miracle drug. I went from barely being able to get out of bed for six years to going back to work full time. This is amazing.
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 69 patient evaluations for Low Dose Naltrexone (LDN)