What is Low Dose Naltrexone (LDN)?

Category: Prescription Drugs

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Generic name: Naltrexone

Naltrexone is FDA approved for alcohol and opioid dependence at 50mg doses. Pilot and preliminary studies of its use in low doses suggest there may be some positive effect for certain conditions.

Reported purpose & perceived effectiveness

Purpose
Patients
Patients with evaluations
Perceived effectiveness

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 18
Moderate 27
Mild 67
None 269

Commonly reported side effects and conditions associated with Low Dose Naltrexone (LDN)

Side effect Patients
Vivid dreams 21
Nausea 13
Headaches 9
Stiffness/Spasticity 8
Hot flashes 6
Insomnia 6

Show all 106 reported side effects

Dosages

Based on patients currently taking Low Dose Naltrexone (LDN)

Dosage Patients
4.5 mg daily 69
3 mg daily 29
4 mg daily 10
1 mg daily 7
3.5 mg daily 6
5 mg daily 5
1.5 mg daily 4
2 mg daily 4
2.5 mg daily 4
1 capsule(s) daily 3

See all 29 dosages

Why patients stopped taking Low Dose Naltrexone (LDN)

Multiple reasons could be selected

Reason Patients
Did not seem to work 99
Other 53
Side effects too severe 35
Doctor's advice 28
Expense 11
Personal research 9
Course of treatment ended 5
Change in health plan coverage 2
See all 194 patients who’ve stopped taking Low Dose Naltrexone (LDN)

Duration

Currently taking Low Dose Naltrexone (LDN)

Duration Patients
0-1 month 2
1-3 months 8
3-6 months 10
6 months-1 year 13
1-2 years 18
2 years or more 113

Stopped taking Low Dose Naltrexone (LDN)

Duration Patients
0-1 month 20
1-3 months 32
3-6 months 35
6 months-1 year 25
1-2 years 52
2 years or more 33

Adherence


Always
Patients
331
87%
Usually
Patients
37
10%
Sometimes
Patients
6
2%
Never taken as prescribed
Patients
7
2%

Burden


Very hard to take
Patients
5
1%
Somewhat hard to take
Patients
20
5%
A little hard to take
Patients
32
8%
Not at all hard to take
Patients
324
85%

Cost per month


Cost per month
$200+
Patients
1
0%
Cost per month
$100-199
Patients
2
1%
Cost per month
$50-99
Patients
42
11%
Cost per month
$25-49
Patients
183
48%
Cost per month
< $25
Patients
110
29%
Cost per month
Not specified
Patients
43
11%

What people switch to and from

Patients started taking Low Dose Naltrexone (LDN) after stopping:

Treatment Patients
Pregabalin (Lyrica) 4
Gabapentin (Neurontin) 3
Hydrocodone-Acetaminophen (Vicodin) 3
Amitriptyline (Elavil) 2
Prednisone (Deltasone) 2

Show all 26 treatments patients report switching from

Patients stopped taking Low Dose Naltrexone (LDN) and switched to:

Treatment Patients
Dimethyl fumarate (Tecfidera) 1
Valacyclovir (Valtrex) 1
Last updated:

71 patient evaluations for Low Dose Naltrexone (LDN)

Alexjeremy
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Alexjeremy
Gender: M
Data Quality: 1 star
Depression: 2
Mania: 2
Emotional: 3
Anxiety: 3
Compulsion: 1
External Stress: Overwhelming
30 M
Function: Moderate
Distress: Moderate
I am: n
I have:
GAD

See Alexjeremy's full Low Dose Naltrexone (LDN) history

Mar 31, 2016 (Started Sep 01, 2015)

  • Effectiveness
    Slight (for Alcohol consumption)
  • side effects
    None
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 50 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks
kcj1963
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kcj1963
Sex: M
Data Quality: 2 stars
Sensation: Moderate
Overall: Moderate
Cognition: moderate
Vision: mild
Speech: moderate
Swallowing: moderate
Upper limb: moderate
Walking: moderate
I am: n
I have:
MS

See kcj1963's full Low Dose Naltrexone (LDN) history

Mar 24, 2016 (Started Apr 15, 2015)

  • Effectiveness
    Can’t tell (for Multiple Sclerosis)
  • side effects
    Mild (Dehydration, Headaches in morning)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 mg Daily
Advice & Tips: low toxicity, defintintely helps with depression and nerve pain
Cost: $25-49 monthly

  • 1 helpful mark
woofhound
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woofhound
Gender: M
Data Quality: 3 stars
Pain: Little
Fatigue: Most
Sleep: Some
Stiffness: All
function: Most
external_stress: Little
Stickman: most
Description:M58y
CFS:10y Dx
FM:16y Dx
I am: vb
I have:
Fibromyalgia

See woofhound's full Low Dose Naltrexone (LDN) history

Oct 1, 2015 (Started Aug 24, 2015)

  • Effectiveness
    Moderate (for Fibromyalgia)
  • Effectiveness
    Moderate (for Fatigue)
  • side effects
    None
  • Adherence
    Always
  • Burden
    Somewhat hard to take
Dosage: 5 mg Daily
Advice & Tips: I make my own solution by dissolving pill in distilled water and take it in daily portions. This is a bit of a pain, but much easier than paying for a compounding pharmacy.

  • 1 helpful mark
Last updated:
Showing 3 of 71 patient evaluations for Low Dose Naltrexone (LDN)