What is Low Dose Naltrexone (LDN)?

Category: Prescription Drugs

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Generic name: Naltrexone

Naltrexone is FDA approved for alcohol and opioid dependence at 50mg doses. Pilot and preliminary studies of its use in low doses suggest there may be some positive effect for certain conditions.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple Sclerosis 414 309
Fibromyalgia 126 200
Fatigue 109 164
Pain 42 56
ALS (Amyotrophic Lateral Sclerosis) 33 29
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 33 93

Show all 142 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 31
Moderate 47
Mild 184
None 500

Commonly reported side effects and conditions associated with Low Dose Naltrexone (LDN)

Side effect Patients
Vivid dreams 22
Nausea 12
Headaches 11
Stiffness/Spasticity 8
Diarrhea 6
Hot flashes 6

Show all 104 reported side effects

Dosages

Based on patients currently taking Low Dose Naltrexone (LDN)

Dosage Patients
4.5 mg daily 47
3 mg daily 21
4 mg daily 10
1.5 mg daily 7
3.5 mg daily 4
1 capsule(s) daily 3
1 mg daily 3
2 mg daily 3
2.5 mg daily 3
4.5 mL daily 3

See all 23 dosages

Why patients stopped taking Low Dose Naltrexone (LDN)

Multiple reasons could be selected

Reason Patients
Did not seem to work 108
Other 53
Side effects too severe 38
Doctor's advice 30
Expense 14
Personal research 10
Course of treatment ended 5
Change in health plan coverage 1
See all 207 patients who’ve stopped taking Low Dose Naltrexone (LDN)

Duration

Currently taking Low Dose Naltrexone (LDN)

Duration Patients
Less than 1 month 1
1 - 6 months 17
6 months - 1 year 12
1 - 2 years 19
2 - 5 years 22
5 - 10 years 43
10 years or more 7

Stopped taking Low Dose Naltrexone (LDN)

Duration Patients
Less than 1 month 23
1 - 6 months 70
6 months - 1 year 27
1 - 2 years 53
2 - 5 years 29
5 - 10 years 8
Adherence
Adherence Evaluations
Always 646
Usually 86
Sometimes 16
Never taken as prescribed 14
Burden
Burden Evaluations
Very hard to take 9
Somewhat hard to take 32
A little hard to take 104
Not at all hard to take 617
Cost per month
Cost per month Evaluations
$200+ 7
$100-199 5
$50-99 92
$25-49 384
< $25 201
Not specified 73

What people switch to and from

Patients started taking Low Dose Naltrexone (LDN) after stopping:

Treatment Patients
Hydrocodone-Acetaminophen (Vicodin) 5
Pregabalin (Lyrica) 5
Prednisone (Deltasone) 4
Gabapentin (Neurontin) 3
Amitriptyline (Elavil) 2

Show all 34 treatments patients report switching from

Patients stopped taking Low Dose Naltrexone (LDN) and switched to:

Treatment Patients
Dimethyl fumarate (Tecfidera) 1
Fingolimod (Gilenya) 1
Hydrocodone-Acetaminophen (Vicodin) 1
Sulfasalazine (Salazopyrin) 1
Valacyclovir (Valtrex) 1
Last updated:

70 patient evaluations for Low Dose Naltrexone (LDN)

414 members have decided to share their profiles only with other members of PatientsLikeMe.

gummitarzan
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gummitarzan
Data Quality: 3 stars
  • Gender: M
  • Age: 69
Condition: Rheumatoid Arthritis (RA) 5 additional condition(s)
Quality of life:
  • Mental: None
  • Physical: Mild
I am: n
I have:
Rheumatoid Arthritis (RA)

See gummitarzan's full Low Dose Naltrexone (LDN) history

Dec 31, 2016 (Started Jan 31, 2015)

  • Effectiveness
    Can’t tell (for Rheumatoid Arthritis (RA))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2.2 mg Daily
Advice & Tips: My third attempt started on 2016-10-31, still taking Sulfasalazine. I am out of Prednisolone and Leflunomide and I have no need for painkillers. That being said, I do have pains in both arms and hands.
Cost: < $25 monthly

Sep 1, 2016 (Started Jan 31, 2015)

  • Effectiveness
    Can’t tell (for Rheumatoid Arthritis (RA))
  • Side effects
    None
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: 1.5 mg Daily
Advice & Tips: I have to try out Sulfasalazine once more (after a 4 year break), and I don't want LDN to affect the result.
Cost: < $25 monthly

Mar 10, 2015 (Started Jan 31, 2015)

  • Effectiveness
    Can’t tell (for Rheumatoid Arthritis (RA))
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 1.5 mg Daily
Advice & Tips: First I had a positive effect, but after approx 25 days I felt bad again. So I take a reading break to find out what I did wrong.
Cost: < $25 monthly

  • 0 helpful marks
Alexjeremy
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Alexjeremy
Gender: M
Data Quality: 1 star
Depression: 2
Mania: 2
Emotional: 3
Anxiety: 3
Compulsion: 1
External Stress: Overwhelming
31 M
Function: Moderate
Distress: Moderate
I am: g
I have:
GAD

See Alexjeremy's full Low Dose Naltrexone (LDN) history

Mar 31, 2016 (Started Sep 01, 2015)

  • Effectiveness
    Slight (for Alcohol consumption)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 50 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks
kcj1963
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kcj1963
Sex: M
Data Quality: 2 stars
Sensation: Moderate
Overall: Moderate
Cognition: moderate
Vision: mild
Speech: moderate
Swallowing: moderate
Upper limb: moderate
Walking: moderate
I am: n
I have:
MS

See kcj1963's full Low Dose Naltrexone (LDN) history

Mar 24, 2016 (Started Apr 15, 2015)

  • Effectiveness
    Can’t tell (for Multiple Sclerosis)
  • Side effects
    Mild (Dehydration, Headaches in morning)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 3 mg Daily
Advice & Tips: low toxicity, defintintely helps with depression and nerve pain
Cost: $25-49 monthly

  • 1 helpful mark
Last updated:
Showing 3 of 70 patient evaluations for Low Dose Naltrexone (LDN)