What is Low Dose Naltrexone (LDN)?

Category: Prescription Drugs

true

Generic name: Naltrexone

Naltrexone is intended for the management of alcohol and opioid dependence. It may be used for it's positive effects on certain conditions.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Multiple Sclerosis 415 310
Fibromyalgia 129 206
Fatigue 110 164
Pain 41 57
ALS (Amyotrophic Lateral Sclerosis) 33 29
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 33 93

Show all 141 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 31
Moderate 47
Mild 189
None 510

Commonly reported side effects and conditions associated with Low Dose Naltrexone (LDN)

Side effect Patients
Vivid dreams 23
Nausea 12
Headaches 11
Stiffness/Spasticity 8
Diarrhea 6
Hot flashes 6

Show all 105 reported side effects

Dosages

Based on patients currently taking Low Dose Naltrexone (LDN)

Dosage Patients
4.5 mg daily 43
3 mg daily 21
1.5 mg daily 9
4 mg daily 9
2 mg daily 5
50 mg daily 4
1 mg daily 3
2.5 mg daily 3
0.25 mg daily 2
1 capsule(s) daily 2

See all 19 dosages

Why patients stopped taking Low Dose Naltrexone (LDN)

Multiple reasons could be selected

Reason Patients
Did not seem to work 112
Other 56
Side effects too severe 38
Doctor's advice 30
Expense 15
Personal research 11
Course of treatment ended 5
Change in health plan coverage 2
See all 213 patients who’ve stopped taking Low Dose Naltrexone (LDN)

Duration

Currently taking Low Dose Naltrexone (LDN)

Duration Patients
Less than 1 month 1
1 - 6 months 19
6 months - 1 year 6
1 - 2 years 15
2 - 5 years 29
5 - 10 years 37
10 years or more 5

Stopped taking Low Dose Naltrexone (LDN)

Duration Patients
Less than 1 month 25
1 - 6 months 70
6 months - 1 year 28
1 - 2 years 54
2 - 5 years 31
5 - 10 years 8
Adherence
Adherence Evaluations
Always 655
Usually 89
Sometimes 16
Never taken as prescribed 17
Burden
Burden Evaluations
Very hard to take 11
Somewhat hard to take 32
A little hard to take 104
Not at all hard to take 630
Cost per month
Cost per month Evaluations
$200+ 7
$100-199 5
$50-99 94
$25-49 392
< $25 202
Not specified 77

What people switch to and from

Patients started taking Low Dose Naltrexone (LDN) after stopping:

Treatment Patients
Hydrocodone-Acetaminophen (Norco) 5
Pregabalin (Lyrica) 5
Prednisone (Deltasone) 4
Gabapentin (Neurontin) 3
Milnacipran (Savella) 3

Show all 36 treatments patients report switching from

Patients stopped taking Low Dose Naltrexone (LDN) and switched to:

Treatment Patients
Dimethyl fumarate (Tecfidera) 1
Fingolimod (Gilenya) 1
Hydrocodone-Acetaminophen (Norco) 1
Sulfasalazine (Salazopyrin) 1
Valacyclovir (Valtrex) 1
Last updated:

70 patient evaluations for Low Dose Naltrexone (LDN)

421 members have decided to share their profiles only with other members of PatientsLikeMe.

gummitarzan
46280 thumb
gummitarzan
Data Quality: 3 stars
  • Gender: M
  • Age: 70
Condition: Rheumatoid Arthritis (RA) 5 additional condition(s)
Quality of life:
  • Mental: None
  • Physical: Mild
I am: n
I have:
Rheumatoid Arthritis (RA)

See gummitarzan's full Low Dose Naltrexone (LDN) history

Mar 21, 2017 (Started Jan 31, 2015)

  • Effectiveness
    Slight (for Rheumatoid Arthritis (RA))
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Advice & Tips: I am convinced LDN helps slightly but it not enough. 5 month without painkillers and only twice shortly om prednisolone should indicate some effect. Only I can't go on just now, my pains are too severe.
Cost: < $25 monthly

Dec 31, 2016 (Started Jan 31, 2015)

  • Effectiveness
    Can’t tell (for Rheumatoid Arthritis (RA))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 2.2 mg Daily
Advice & Tips: My third attempt started on 2016-10-31, still taking Sulfasalazine. I am out of Prednisolone and Leflunomide and I have no need for painkillers. That being said, I do have pains in both arms and hands.
Cost: < $25 monthly

Sep 1, 2016 (Started Jan 31, 2015)

  • Effectiveness
    Can’t tell (for Rheumatoid Arthritis (RA))
  • Side effects
    None
  • Adherence
    Sometimes
  • Burden
    Not at all hard to take
Dosage: 1.5 mg Daily
Advice & Tips: I have to try out Sulfasalazine once more (after a 4 year break), and I don't want LDN to affect the result.
Cost: < $25 monthly

Mar 10, 2015 (Started Jan 31, 2015)

  • Effectiveness
    Can’t tell (for Rheumatoid Arthritis (RA))
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    A little hard to take
Dosage: 1.5 mg Daily
Advice & Tips: First I had a positive effect, but after approx 25 days I felt bad again. So I take a reading break to find out what I did wrong.
Cost: < $25 monthly

  • 0 helpful marks
slowrambler
Portrait default thumb
slowrambler
Sex: M
Data Quality: 2 stars
Relapse: Moderate
Sensation: Severe
Overall: Mild
Cognition: none
Vision: none
Speech: none
Swallowing: none
Upper limb: none
Walking: severe
I am: b
I have:
MS

See slowrambler's full Low Dose Naltrexone (LDN) history

Mar 5, 2017 (Started Sep 01, 2008)

  • Effectiveness
    Moderate (for Multiple Sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Cost: $50-99 monthly

Sep 7, 2012 (Started Sep 01, 2008)

  • Effectiveness
    Major (for Multiple Sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Advice & Tips: This medication's given me some very un-expected increase in heat tolerance.
Cost: $50-99 monthly

Feb 9, 2009 (Started Sep 01, 2008)

  • Effectiveness
    Major (for Multiple Sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Cost: $50-99 monthly

Sep 7, 2008 (Started Sep 01, 2008)

  • Effectiveness
    Major (for Multiple Sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 4.5 mg Daily
Advice & Tips: This medication is FDA approved for MS in "compounded" form only. If an MS patient can obtain a prescription for this medication (many neurologists won't consider writing a script for this), they'll need to have access to a "compounding" pharmacy. As with all medications, success rates appear to vary. Many people who I know that are using LDN have realized dramatic, if not astonishing symptomatic relief in addition to less disease activity. Some that I know tried it for a period of time without any noticible relief or change & thus stopped using it. Success rates have seemed to depend on dosage level, at least from my observations. Some using LDN notice change almost immediately at the lower dosage levels. Others, as noted above, realize no change at any dosage level. Personally, the symptom relief that I've noticed most is an increase in heat tolerance. As far as my overall success rate, I'd say this medication has done very well in slowing the progression. I've gone over 15 months without having an exacerbation or needing IV solu-medrol. 11 of those months have been since I began using LDN, & I'm not using highest dosage. Maintaining my mobility level & being essentially symptom free for this period of time is very unusual (& quite pleasant!) for me; especially over the last 3 yrs. Note: neurologists/MS specialists might recommend a dormant period of time between stopping a current medication (Beta-Seron, Avonex, etc.) & the beginning of LDN use.
Cost: $50-99 monthly

  • 4 helpful marks
Alexjeremy
31100 thumb
Alexjeremy
Gender: M
Data Quality: 1 star
Depression: 2
Mania: 2
Emotional: 3
Anxiety: 3
Compulsion: 1
External Stress: Overwhelming
31 M
Function: Moderate
Distress: Moderate
I am: g
I have:
GAD

See Alexjeremy's full Low Dose Naltrexone (LDN) history

Mar 31, 2016 (Started Sep 01, 2015)

  • Effectiveness
    Slight (for Alcohol consumption)
  • Side effects
    None
  • Adherence
    Usually
  • Burden
    Somewhat hard to take
Dosage: 50 mg Daily
Cost: $25-49 monthly

  • 0 helpful marks
Last updated:
Showing 3 of 70 patient evaluations for Low Dose Naltrexone (LDN)