What is Duloxetine?

Category: Prescription Drugs

Most popular types: Cymbalta Cymgen Yentreve Show all

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Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It may be used for depression, general anxiety disorder, pain associated with diabetic neuropathy and fibromyalgia.

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Fibromyalgia 5,878 2,892
Depressed mood 1,954 1,105
Major Depressive Disorder 1,655 1,005
Generalized Anxiety Disorder 716 503
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 686 369
Pain 518 291

Show all 343 reasons taken


  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations
Severe 863
Moderate 919
Mild 1,067
None 1,546

Commonly reported side effects and conditions associated with Duloxetine

Side effect Patients
Weight gain 274
Nausea 272
Dizziness 157
Sex drive (libido) decreased 154
Dry mouth 151
Sweating increased 100

Show all 713 reported side effects

Dosages

Based on patients currently taking Duloxetine

Dosage Patients
60 mg daily 517
30 mg daily 207
120 mg daily 123
60 mg twice daily 95
90 mg daily 94
20 mg daily 73
30 mg twice daily 45
40 mg daily 34
120 mg twice daily 21
20 mg twice daily 10

See all 59 dosages

Why patients stopped taking Duloxetine

Multiple reasons could be selected

Reason Patients
Side effects too severe 1656
Did not seem to work 1440
Doctor's advice 538
Expense 427
Other 405
Personal research 158
Change in health plan coverage 150
Course of treatment ended 63
See all 3253 patients who’ve stopped taking Duloxetine

Duration

Currently taking Duloxetine

Duration Patients
Less than 1 month 8
1 - 6 months 97
6 months - 1 year 185
1 - 2 years 241
2 - 5 years 347
5 - 10 years 332
10 years or more 134

Stopped taking Duloxetine

Duration Patients
Less than 1 month 709
1 - 6 months 931
6 months - 1 year 530
1 - 2 years 463
2 - 5 years 478
5 - 10 years 128
10 years or more 30
Adherence
Adherence Evaluations
Always 3697
Usually 385
Sometimes 63
Never taken as prescribed 250
Burden
Burden Evaluations
Very hard to take 271
Somewhat hard to take 342
A little hard to take 515
Not at all hard to take 3267
Cost per month
Cost per month Evaluations
$200+ 122
$100-199 186
$50-99 416
$25-49 649
< $25 1384
Not specified 1638

What people switch to and from

Patients started taking Duloxetine after stopping:

Treatment Patients
Pregabalin (Lyrica) 125
Fluoxetine (Prozac) 96
Venlafaxine (Effexor XR) 89
Sertraline (Zoloft) 81
Escitalopram (Lexapro) 72

Show all 67 treatments patients report switching from

Patients stopped taking Duloxetine and switched to:

Treatment Patients
Pregabalin (Lyrica) 60
Venlafaxine (Effexor XR) 55
Gabapentin (Neurontin) 38
Bupropion (Wellbutrin XL) 30
Sertraline (Zoloft) 30

Show all 66 treatments patients report switching to

Last updated:

315 patient evaluations for Duloxetine

3,557 members have decided to share their profiles only with other members of PatientsLikeMe.

Tulabee
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Tulabee
Sex: F
Data Quality: 3 stars
On
Mouth/throat: mild
Arms: mild
Chest: mild
Legs: mild
I am: g
I have:
Parkinson's

See Tulabee's full Duloxetine history

Mar 6, 2017 (Started Apr 15, 2014)

  • Effectiveness
    Slight (for Parkinson's Disease)
  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Mild (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: I am on 2x60mg and tried to cut back to 1x in mid February. That was too soon. Also, I am waking up in the daylight hours, and am not working at UTC anymore. I am trying not to use modafinil for wakefulness.
Cost: < $25 monthly
Side effects: Excessive daytime sleepiness (somnolence)

Sep 23, 2016 (Started Apr 15, 2014)

  • Effectiveness
    Can’t tell (for Parkinson's Disease)
  • Effectiveness
    Moderate (for Depressed mood)
  • Side effects
    Moderate (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 120 mg Daily
Advice & Tips: I have gone up in dosage from 60mg/day to 120mg/day, since Sept 1. Since I am ahead of my usual "sometime in Sept -Oct"schedule, Psychiatrist called it prophylactic. Said to call his office if I need to change med schedule. Aass for cost, I have met my yearly out-of-pocket, so i pay nothing.
Cost: < $25 monthly
Side effects: Excessive daytime sleepiness (somnolence)

Feb 1, 2015 (Started Apr 15, 2014)

  • Effectiveness
    Major (for Depressed mood)
  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    Mild (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I am taking 2x60mg at night, and 0.75 L-dopa every 4.25 hrs.
Cost: $25-49 monthly
Side effects: Excessive daytime sleepiness (somnolence)

May 11, 2014 (Started Apr 15, 2014)

  • Effectiveness
    Major (for Depressed mood)
  • Effectiveness
    Slight (for Parkinson's Disease)
  • Side effects
    Moderate (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 60 mg Daily
Advice & Tips: I have noticed that when taking 2x60mg, the L-dopa 25/100 can be taken 4-5 hours. When taking 60mg Cymbalta, the L-dopa is about 3-4hrs. IS it regulating the release? I like the 2x60mg. I wonder if it is causing sleepiness as I usually cut dosage in the SPringtime. It will take weeks to figure this out. I don't want to wreck my summer. Also, Cymbalta trashes the sex drive.
Cost: $25-49 monthly
Side effects: Excessive daytime sleepiness (somnolence)

Apr 18, 2013 (Started Apr 15, 2014)

  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Mild (Excessive daytime sleepiness (somnolence), Sleepiness)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: I will take this until the effectivess goes away.
Cost: $25-49 monthly
Side effects: Excessive daytime sleepiness (somnolence)

Aug 23, 2011 (Started Apr 15, 2014)

  • Effectiveness
    Major (for Depressed mood)
  • Side effects
    Moderate (Excessive daytime sleepiness (somnolence))
  • Adherence
    Always
  • Burden
    Not at all hard to take
Advice & Tips: Cymbalta has been working for me for dysthymia.
Cost: $25-49 monthly
Side effects: Excessive daytime sleepiness (somnolence)

  • 0 helpful marks
Chrismh1
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Chrismh1
Gender: M
Data Quality: 2 stars
Depression: 3
Mania: 1
Emotional: 1
Anxiety: 2
Compulsion: 3
External Stress: Low
45 M
Function: Moderate
Distress: Moderate
I am: n
I have:
Bipolar I

See Chrismh1's full Duloxetine history

Nov 19, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Feb 17, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    Mild (Seizures)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Feb 3, 2016 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    Mild (Seizures)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Cost: < $25 monthly

Jul 25, 2015 (Started Oct 10, 2012)

  • Effectiveness
    Can’t tell (for Postpartum Depression)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take

  • 0 helpful marks
a-non-mouse
17881 thumb
a-non-mouse
Sex: M
Data Quality: 2 stars
Sensation: Moderate
Overall: Mild
Cognition: mild
Vision: none
Speech: none
Swallowing: none
Upper limb: mild
Walking: severe
I am: g
I have:
MS

See a-non-mouse's full Duloxetine history

Nov 16, 2016 (Started Apr 30, 2015)

  • Effectiveness
    Major (for Nerve pain (neuralgia))
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 30 mg Daily
Advice & Tips: Cymbalta reduces or eliminates nerve pain that off the shelf pain killers can't tackle.

  • 0 helpful marks
Last updated:
Showing 3 of 315 patient evaluations for Duloxetine