Hereditary spastic paraplegia

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What is hereditary spastic paraplegia?

Hereditary Spastic Paraplegia is not a single disease but a group of genetic disorders in which the main feature is progressive spasticity in the lower limbs due to pyramidal tract dysfunction. Onset can be at any age, from the first year of life to old age, depending on the specific genetic form.

Common symptoms reported by people with hereditary spastic paraplegia

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
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Treatments taken by people with hereditary spastic paraplegia

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Mylan-Baclofen)
Type
Prescription Drug
How many have tried
3
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
2
Tried for
depressed mood (2)
Treatment name(s)

(Valium)
Type
Prescription Drug
How many have tried
2
Treatment name(s)

(Lyrica)
Type
Prescription Drug
How many have tried
2
Treatment name(s)

(Zanaflex)
Type
Prescription Drug
How many have tried
2
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
1
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
1
Tried for
depressed mood (1)
Treatment name(s)

(Advil)
Type
Over the Counter Drug
How many have tried
1
Tried for
pain (1)
Treatment name(s)

(Cannabidiol/Tetrahydrocannabinol Balanced Mixture)
Type
Prescription Drug
How many have tried
1
Tried for
pain (1)
Treatment name(s)

(Breath Meditation)
Type
Complementary and Alternative Medicine
How many have tried
1
Tried for
anxious mood (1) pain (1)

Data from patients with hereditary spastic paraplegia, who reported starting treatments within the last 5 years.
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Compare treatments taken by people with hereditary spastic paraplegia

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Mylan-Baclofen)
Perceived effectiveness
for hereditary spastic paraplegia (3 evaluations)
Side effects
spaced out weakness in leg(s)
Total evaluations
3
Treatment name(s)

(Celexa)
Perceived effectiveness
for depressed mood (3 evaluations)
Side effects
spaced out
Total evaluations
3
Tried for
depressed mood (2)
Treatment name(s)

(Valium)
Perceived effectiveness
for hereditary spastic paraplegia (3 evaluations)
Side effects
Total evaluations
3
Treatment name(s)

(Lyrica)
Perceived effectiveness
for hereditary spastic paraplegia (1 evaluation)
Side effects
sleepiness
Total evaluations
2
Treatment name(s)

(Zanaflex)
Perceived effectiveness
for hereditary spastic paraplegia (3 evaluations)
Side effects
dizziness dry mouth
Total evaluations
8
Treatment name(s)

(Klonopin)
Perceived effectiveness
for hereditary spastic paraplegia (2 evaluations)
Side effects
Total evaluations
2
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for depressed mood (1 evaluation)
Side effects
Total evaluations
1
Tried for
depressed mood (1)
Treatment name(s)

(Advil)
Perceived effectiveness
for pain (1 evaluation)
Side effects
Total evaluations
1
Tried for
pain (1)
Treatment name(s)

(Cannabidiol/Tetrahydrocannabinol Balanced Mixture)
Perceived effectiveness
for pain (2 evaluations)
Side effects
high feeling
Total evaluations
2
Tried for
pain (1)
Treatment name(s)

(Breath Meditation)
Perceived effectiveness
for anxious mood (2 evaluations)
Side effects
Total evaluations
2
Tried for
anxious mood (1) pain (1)
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with hereditary spastic paraplegia, who reported starting treatments within the last 5 years.
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Who has hereditary spastic paraplegia on PatientsLikeMe?


Age
Age Proportion # of patients
<20 7
20s 13
30s 26
40s 44
50s 52
60s 38
70+ 18
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 27
20-29 years 13
30-39 years 18
40-49 years 18
50-59 years 14
60-69 years 1
70+ years 0

Distribution of sex

Sex
Sex Proportion # of patients
Male 80
Female 124

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 94
Not Diagnosed 13

These charts show data from hereditary spastic paraplegia patients who have completed their condition history
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