Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
738
Tried for
Major Depressive Disorder (697) Depressed mood (87)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
648
Tried for
Major Depressive Disorder (597) Depressed mood (123)
8 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
588
Tried for
Major Depressive Disorder (483) Depressed mood (215)
7 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
531
Tried for
Major Depressive Disorder (465) Depressed mood (159)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
522
Tried for
Major Depressive Disorder (518) Depressed mood (9)
5 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
482
Tried for
Major Depressive Disorder (408) Depressed mood (158)
3 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
361
Tried for
Major Depressive Disorder (344) Depressed mood (61)
2 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
361
Tried for
Major Depressive Disorder (328) Anxious mood (67)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
284
Tried for
Anxious mood (279) Insomnia (12)
3 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
218
Tried for
Insomnia (208) Major Depressive Disorder (23)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (368 evaluations)
Side effects
Anxious mood Headaches 161 more
How many evaluations
427
Tried for
Major Depressive Disorder (697) Depressed mood (87)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (313 evaluations)
Side effects
Dry mouth Nausea 133 more
How many evaluations
421
Tried for
Major Depressive Disorder (597) Depressed mood (123)
8 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (271 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 151 more
How many evaluations
371
Tried for
Major Depressive Disorder (483) Depressed mood (215)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (277 evaluations)
Side effects
Dry mouth Weight gain 148 more
How many evaluations
346
Tried for
Major Depressive Disorder (465) Depressed mood (159)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for Major Depressive Disorder (223 evaluations)
Side effects
Anxious mood Depressed mood 57 more
How many evaluations
271
Tried for
Major Depressive Disorder (518) Depressed mood (9)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (222 evaluations)
Side effects
Nausea Suicidal thoughts or urges 116 more
How many evaluations
284
Tried for
Major Depressive Disorder (408) Depressed mood (158)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (198 evaluations)
Side effects
Dry mouth Sleepiness 98 more
How many evaluations
230
Tried for
Major Depressive Disorder (344) Depressed mood (61)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (181 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 92 more
How many evaluations
220
Tried for
Major Depressive Disorder (328) Anxious mood (67)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (156 evaluations)
Side effects
Drowsiness Sleepiness 38 more
How many evaluations
173
Tried for
Anxious mood (279) Insomnia (12)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (104 evaluations)
Side effects
Dry mouth Drowsiness 46 more
How many evaluations
112
Tried for
Insomnia (208) Major Depressive Disorder (23)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 477
20s 3,996
30s 7,304
40s 9,763
50s 9,493
60s 4,471
70+ 687

Sex

Distribution of sex

76% Female
24% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 6,368
20-29 years 2,465
30-39 years 1,690
40-49 years 1,010
50-59 years 320
60-69 years 53
70+ years 6

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 16,046
Not Diagnosed 2,223

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: