Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
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Treatments taken by people for major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin)
Type
Prescription Drug
How many have tried
16133
Tried for
major depressive disorder (168)
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
11844
Tried for
major depressive disorder (118)
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
19164
Tried for
major depressive disorder (106)
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
15524
Tried for
major depressive disorder (103)
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
23630
Tried for
major depressive disorder (93)
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
10575
Tried for
major depressive disorder (81)
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
18412
Tried for
major depressive disorder (67)
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
10840
Tried for
major depressive disorder (36)

Data from patients with major depressive disorder, who have ever reported treatments, ordered by their reporting frequency during the last 5 years.
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Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin)
Perceived effectiveness
for major depressive disorder (79 evaluations)
Side effects
dry mouth anxious mood 49 more
Total evaluations
81
Tried for
major depressive disorder (168)
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (63 evaluations)
Side effects
dry mouth decreased sex drive (libido) 24 more
Total evaluations
64
Tried for
major depressive disorder (118)
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (47 evaluations)
Side effects
nausea weight gain 48 more
Total evaluations
49
Tried for
major depressive disorder (106)
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (61 evaluations)
Side effects
nausea dizziness 49 more
Total evaluations
64
Tried for
major depressive disorder (103)
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (29 evaluations)
Side effects
flashbacks emotional lability 8 more
Total evaluations
33
Tried for
major depressive disorder (93)
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (45 evaluations)
Side effects
dry mouth brain fog 40 more
Total evaluations
45
Tried for
major depressive disorder (81)
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (37 evaluations)
Side effects
headaches nausea 25 more
Total evaluations
39
Tried for
major depressive disorder (67)
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (30 evaluations)
Side effects
dizziness nausea 8 more
Total evaluations
30
Tried for
major depressive disorder (36)
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who have ever reported treatments, ordered by their reporting frequency during the last 5 years.
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Who has major depressive disorder on PatientsLikeMe?

  • 41 new patients joined this month
  • 33073 say MDD is their primary condition

Age
Age Proportion # of patients
<20 143
20s 3326
30s 8566
40s 13381
50s 17210
60s 13112
70+ 3972
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8857
20-29 years 3722
30-39 years 2744
40-49 years 1753
50-59 years 611
60-69 years 115
70+ years 21

Distribution of sex

Sex
Sex Proportion # of patients
Male 12436
Female 47605

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23960
Not Diagnosed 2340

These charts show data from MDD patients who have completed their condition history
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