Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
883
Tried for
major depressive disorder (839) depressed mood (99)
6 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
696
Tried for
major depressive disorder (648) depressed mood (138)
3 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
642
Tried for
major depressive disorder (538) depressed mood (228)
5 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
611
Tried for
major depressive disorder (605) anxious mood (10)
4 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
594
Tried for
major depressive disorder (522) depressed mood (182)
5 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
549
Tried for
major depressive disorder (466) depressed mood (186)
3 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
440
Tried for
major depressive disorder (396) anxious mood (83)
1 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
358
Tried for
major depressive disorder (340) depressed mood (56)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
281
Tried for
anxious mood (278) major depressive disorder (6)
2 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
179
Tried for
depressed mood (145) major depressive disorder (39)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
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Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (435 evaluations)
Side effects
anxious mood headaches 173 more
Total evaluations
498
Tried for
major depressive disorder (839) depressed mood (99)
6 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (353 evaluations)
Side effects
dry mouth weight gain 166 more
Total evaluations
467
Tried for
major depressive disorder (648) depressed mood (138)
3 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (307 evaluations)
Side effects
decreased sex drive (libido) weight gain 163 more
Total evaluations
405
Tried for
major depressive disorder (538) depressed mood (228)
5 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (306 evaluations)
Side effects
anxious mood depressed mood 66 more
Total evaluations
368
Tried for
major depressive disorder (605) anxious mood (10)
4 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (329 evaluations)
Side effects
dry mouth weight gain 156 more
Total evaluations
405
Tried for
major depressive disorder (522) depressed mood (182)
5 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (250 evaluations)
Side effects
weight gain nausea 117 more
Total evaluations
325
Tried for
major depressive disorder (466) depressed mood (186)
3 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (231 evaluations)
Side effects
weight gain decreased sex drive (libido) 95 more
Total evaluations
276
Tried for
major depressive disorder (396) anxious mood (83)
1 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (201 evaluations)
Side effects
sleepiness dry mouth 96 more
Total evaluations
230
Tried for
major depressive disorder (340) depressed mood (56)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (161 evaluations)
Side effects
drowsiness sleepiness 41 more
Total evaluations
171
Tried for
anxious mood (278) major depressive disorder (6)
2 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (89 evaluations)
Side effects
weight gain nausea 72 more
Total evaluations
133
Tried for
depressed mood (145) major depressive disorder (39)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
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Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 556
20s 4,800
30s 9,293
40s 13,326
50s 13,485
60s 6,568
70+ 1,105
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 7,828
20-29 years 3,293
30-39 years 2,340
40-49 years 1,475
50-59 years 498
60-69 years 95
70+ years 12

Sex

Distribution of sex

79% Female
21% Male

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 19,664
Not Diagnosed 2,411

These charts show data from MDD patients who have completed their condition history
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