Major depressive disorder

We’re all in this for good.

By sharing your stories and data, you will:
  • help each other live better and uncover the best ways to manage your health today
  • help researchers shorten the path to new treatments tomorrow

How much good can your data do? A whole lot, as co-founder Jamie Heywood explains in this video.

What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
858
Tried for
major depressive disorder (816) Depressed mood (98)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
727
Tried for
major depressive disorder (677) Depressed mood (130)
9 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
654
Tried for
major depressive disorder (544) Depressed mood (236)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
595
Tried for
major depressive disorder (522) Depressed mood (177)
8 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
584
Tried for
major depressive disorder (580) Depressed mood (10)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
535
Tried for
major depressive disorder (449) Depressed mood (179)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
418
Tried for
major depressive disorder (384) Anxious mood (77)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
393
Tried for
major depressive disorder (376) Depressed mood (63)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
310
Tried for
Anxious mood (304) Insomnia (13)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
230
Tried for
Insomnia (219) major depressive disorder (23)
4 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with major depressive disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (430 evaluations)
Side effects
Anxious mood Headaches 173 more
Total evaluations
490
Tried for
major depressive disorder (816) Depressed mood (98)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (369 evaluations)
Side effects
Dry mouth Weight gain 144 more
Total evaluations
473
Tried for
major depressive disorder (677) Depressed mood (130)
9 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (308 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 163 more
Total evaluations
413
Tried for
major depressive disorder (544) Depressed mood (236)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (313 evaluations)
Side effects
Dry mouth Weight gain 165 more
Total evaluations
393
Tried for
major depressive disorder (522) Depressed mood (177)
8 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (284 evaluations)
Side effects
Anxious mood Depressed mood 67 more
Total evaluations
340
Tried for
major depressive disorder (580) Depressed mood (10)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (252 evaluations)
Side effects
Weight gain Nausea 129 more
Total evaluations
322
Tried for
major depressive disorder (449) Depressed mood (179)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (222 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 100 more
Total evaluations
265
Tried for
major depressive disorder (384) Anxious mood (77)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (219 evaluations)
Side effects
Sleepiness Weight gain 100 more
Total evaluations
251
Tried for
major depressive disorder (376) Depressed mood (63)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (175 evaluations)
Side effects
Drowsiness Sleepiness 43 more
Total evaluations
192
Tried for
Anxious mood (304) Insomnia (13)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (112 evaluations)
Side effects
Dry mouth Drowsiness 50 more
Total evaluations
122
Tried for
Insomnia (219) major depressive disorder (23)
4 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 559
20s 4,373
30s 8,151
40s 11,223
50s 11,012
60s 5,121
70+ 797
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 6,838
20-29 years 2,674
30-39 years 1,857
40-49 years 1,124
50-59 years 358
60-69 years 61
70+ years 6

Sex

Distribution of sex

77% Female
23% Male

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 17,005
Not Diagnosed 2,280

These charts show data from MDD patients who have completed their condition history
Last updated: