Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
821
Tried for
major depressive disorder (782) Depressed mood (93)
7 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
655
Tried for
major depressive disorder (612) Depressed mood (120)
8 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
613
Tried for
major depressive disorder (512) Depressed mood (220)
7 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
576
Tried for
major depressive disorder (572) Anxious mood (10)
5 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
548
Tried for
major depressive disorder (483) Depressed mood (164)
8 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
517
Tried for
major depressive disorder (434) Depressed mood (177)
3 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
399
Tried for
major depressive disorder (366) Anxious mood (73)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
354
Tried for
major depressive disorder (341) Depressed mood (55)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
281
Tried for
Anxious mood (275) Insomnia (13)
3 more
Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
213
Tried for
Insomnia (203) major depressive disorder (19)
4 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (417 evaluations)
Side effects
Anxious mood Headaches 172 more
Total evaluations
476
Tried for
major depressive disorder (782) Depressed mood (93)
7 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (336 evaluations)
Side effects
Weight gain Dry mouth 140 more
Total evaluations
434
Tried for
major depressive disorder (612) Depressed mood (120)
8 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (293 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 166 more
Total evaluations
390
Tried for
major depressive disorder (512) Depressed mood (220)
7 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (284 evaluations)
Side effects
Anxious mood Depressed mood 66 more
Total evaluations
342
Tried for
major depressive disorder (572) Anxious mood (10)
5 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (301 evaluations)
Side effects
Dry mouth Weight gain 157 more
Total evaluations
374
Tried for
major depressive disorder (483) Depressed mood (164)
8 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (236 evaluations)
Side effects
Weight gain Nausea 119 more
Total evaluations
307
Tried for
major depressive disorder (434) Depressed mood (177)
3 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (219 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 98 more
Total evaluations
257
Tried for
major depressive disorder (366) Anxious mood (73)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (203 evaluations)
Side effects
Sleepiness Weight gain 100 more
Total evaluations
232
Tried for
major depressive disorder (341) Depressed mood (55)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (153 evaluations)
Side effects
Drowsiness Sleepiness 41 more
Total evaluations
170
Tried for
Anxious mood (275) Insomnia (13)
3 more
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (103 evaluations)
Side effects
Dry mouth Drowsiness 49 more
Total evaluations
113
Tried for
Insomnia (203) major depressive disorder (19)
4 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
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Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 558
20s 4,464
30s 8,403
40s 11,674
50s 11,447
60s 5,408
70+ 864
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 6,930
20-29 years 2,737
30-39 years 1,889
40-49 years 1,148
50-59 years 366
60-69 years 63
70+ years 5

Sex

Distribution of sex

77% Female
23% Male

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 17,279
Not Diagnosed 2,297

These charts show data from MDD patients who have completed their condition history
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