Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
924
Tried for
major depressive disorder (875) depressed mood (103)
5 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
697
Tried for
major depressive disorder (652) depressed mood (129)
6 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
637
Tried for
major depressive disorder (534) depressed mood (223)
4 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
615
Tried for
major depressive disorder (609) anxious mood (10)
6 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
615
Tried for
major depressive disorder (539) depressed mood (184)
5 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
549
Tried for
major depressive disorder (467) depressed mood (180)
4 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
445
Tried for
major depressive disorder (400) anxious mood (90)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
348
Tried for
major depressive disorder (330) depressed mood (49)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
283
Tried for
anxious mood (280) major depressive disorder (6)
3 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
195
Tried for
depressed mood (154) major depressive disorder (48)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
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Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (449 evaluations)
Side effects
anxious mood headaches 173 more
Total evaluations
510
Tried for
major depressive disorder (875) depressed mood (103)
5 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (352 evaluations)
Side effects
dry mouth weight gain 169 more
Total evaluations
466
Tried for
major depressive disorder (652) depressed mood (129)
6 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (316 evaluations)
Side effects
decreased sex drive (libido) weight gain 158 more
Total evaluations
408
Tried for
major depressive disorder (534) depressed mood (223)
4 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (302 evaluations)
Side effects
anxious mood flashbacks 53 more
Total evaluations
363
Tried for
major depressive disorder (609) anxious mood (10)
6 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (335 evaluations)
Side effects
dry mouth weight gain 154 more
Total evaluations
406
Tried for
major depressive disorder (539) depressed mood (184)
5 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (250 evaluations)
Side effects
weight gain nausea 121 more
Total evaluations
322
Tried for
major depressive disorder (467) depressed mood (180)
4 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (238 evaluations)
Side effects
decreased sex drive (libido) weight gain 96 more
Total evaluations
282
Tried for
major depressive disorder (400) anxious mood (90)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (181 evaluations)
Side effects
decreased sex drive (libido) dry mouth 90 more
Total evaluations
212
Tried for
major depressive disorder (330) depressed mood (49)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (158 evaluations)
Side effects
drowsiness sleepiness 39 more
Total evaluations
170
Tried for
anxious mood (280) major depressive disorder (6)
3 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (104 evaluations)
Side effects
weight gain nausea 70 more
Total evaluations
151
Tried for
depressed mood (154) major depressive disorder (48)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
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Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 539
20s 4,895
30s 9,756
40s 13,916
50s 14,576
60s 7,386
70+ 1,318
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8,501
20-29 years 3,644
30-39 years 2,625
40-49 years 1,669
50-59 years 595
60-69 years 110
70+ years 17

Distribution of sex

Sex
Sex Proportion # of patients
Male 11,094
Female 41,508

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 22,950
Not Diagnosed 2,326

These charts show data from MDD patients who have completed their condition history
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