Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
922
Tried for
major depressive disorder (872) depressed mood (107)
5 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
699
Tried for
major depressive disorder (653) depressed mood (133)
5 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
653
Tried for
major depressive disorder (550) depressed mood (228)
4 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
620
Tried for
major depressive disorder (614) anxious mood (10)
4 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
618
Tried for
major depressive disorder (544) depressed mood (184)
5 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
562
Tried for
major depressive disorder (477) depressed mood (186)
4 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
450
Tried for
major depressive disorder (406) anxious mood (87)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
359
Tried for
major depressive disorder (342) depressed mood (54)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
290
Tried for
anxious mood (287) major depressive disorder (6)
3 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
193
Tried for
depressed mood (154) major depressive disorder (45)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
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Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (450 evaluations)
Side effects
anxious mood headaches 175 more
Total evaluations
514
Tried for
major depressive disorder (872) depressed mood (107)
5 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (350 evaluations)
Side effects
dry mouth weight gain 164 more
Total evaluations
467
Tried for
major depressive disorder (653) depressed mood (133)
5 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (320 evaluations)
Side effects
weight gain decreased sex drive (libido) 166 more
Total evaluations
414
Tried for
major depressive disorder (550) depressed mood (228)
4 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (307 evaluations)
Side effects
anxious mood flashbacks 59 more
Total evaluations
370
Tried for
major depressive disorder (614) anxious mood (10)
4 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (341 evaluations)
Side effects
dry mouth weight gain 156 more
Total evaluations
412
Tried for
major depressive disorder (544) depressed mood (184)
5 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (253 evaluations)
Side effects
weight gain nausea 123 more
Total evaluations
331
Tried for
major depressive disorder (477) depressed mood (186)
4 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (236 evaluations)
Side effects
weight gain decreased sex drive (libido) 99 more
Total evaluations
282
Tried for
major depressive disorder (406) anxious mood (87)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (199 evaluations)
Side effects
sleepiness dry mouth 97 more
Total evaluations
229
Tried for
major depressive disorder (342) depressed mood (54)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (165 evaluations)
Side effects
drowsiness sleepiness 41 more
Total evaluations
176
Tried for
anxious mood (287) major depressive disorder (6)
3 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (98 evaluations)
Side effects
weight gain nausea 74 more
Total evaluations
145
Tried for
depressed mood (154) major depressive disorder (45)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
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Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 578
20s 4,974
30s 9,765
40s 13,963
50s 14,380
60s 7,139
70+ 1,234
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8,455
20-29 years 3,619
30-39 years 2,621
40-49 years 1,664
50-59 years 585
60-69 years 108
70+ years 17

Sex

Distribution of sex

79% Female
21% Male

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 21,337
Not Diagnosed 2,511

These charts show data from MDD patients who have completed their condition history
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