Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
664
Tried for
Major Depressive Disorder (623) Depressed mood (83)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
612
Tried for
Major Depressive Disorder (558) Depressed mood (124)
8 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
557
Tried for
Major Depressive Disorder (456) Depressed mood (209)
7 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
488
Tried for
Major Depressive Disorder (423) Depressed mood (150)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
479
Tried for
Major Depressive Disorder (475) Depressed mood (9)
5 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
450
Tried for
Major Depressive Disorder (377) Depressed mood (149)
3 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
345
Tried for
Major Depressive Disorder (328) Depressed mood (61)
2 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
327
Tried for
Major Depressive Disorder (295) Anxious mood (64)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
275
Tried for
Anxious mood (270) Insomnia (12)
3 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
209
Tried for
Insomnia (200) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (323 evaluations)
Side effects
Anxious mood Headaches 153 more
How many evaluations
382
Tried for
Major Depressive Disorder (623) Depressed mood (83)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (292 evaluations)
Side effects
Dry mouth Nausea 126 more
How many evaluations
393
Tried for
Major Depressive Disorder (556) Depressed mood (123)
8 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (259 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 140 more
How many evaluations
353
Tried for
Major Depressive Disorder (455) Depressed mood (208)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (255 evaluations)
Side effects
Dry mouth Weight gain 143 more
How many evaluations
319
Tried for
Major Depressive Disorder (423) Depressed mood (150)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for Major Depressive Disorder (208 evaluations)
Side effects
Anxious mood Depressed mood 53 more
How many evaluations
251
Tried for
Major Depressive Disorder (475) Depressed mood (9)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (195 evaluations)
Side effects
Nausea Weight gain 107 more
How many evaluations
254
Tried for
Major Depressive Disorder (377) Depressed mood (149)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (187 evaluations)
Side effects
Dry mouth Loss of sex drive (libido) 95 more
How many evaluations
218
Tried for
Major Depressive Disorder (328) Depressed mood (61)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (159 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 90 more
How many evaluations
199
Tried for
Major Depressive Disorder (295) Anxious mood (64)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (148 evaluations)
Side effects
Drowsiness Sleepiness 38 more
How many evaluations
165
Tried for
Anxious mood (270) Insomnia (12)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (98 evaluations)
Side effects
Drowsiness Dry mouth 43 more
How many evaluations
105
Tried for
Insomnia (200) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 412
20s 3,760
30s 6,911
40s 8,937
50s 8,561
60s 4,031
70+ 625

Sex

Distribution of sex

76% Female
24% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 6,041
20-29 years 2,330
30-39 years 1,591
40-49 years 953
50-59 years 298
60-69 years 48
70+ years 5

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 15,434
Not Diagnosed 2,188

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: