Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
549
Tried for
Major Depressive Disorder (499) Depressed mood (116)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
523
Tried for
Major Depressive Disorder (481) Depressed mood (82)
6 more
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Treatment name(s)
Type
Psychotherapy
How many have tried
459
Tried for
Major Depressive Disorder (454) Depressed mood (9)
4 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
424
Tried for
Major Depressive Disorder (395) Depressed mood (78)
6 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
404
Tried for
Major Depressive Disorder (376) Depressed mood (70)
3 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
399
Tried for
Major Depressive Disorder (379) Depressed mood (75)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
381
Tried for
Major Depressive Disorder (351) Depressed mood (74)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
275
Tried for
Major Depressive Disorder (245) Depressed mood (52)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
225
Tried for
Anxious mood (206) Insomnia (22)
4 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
163
Tried for
Insomnia (146) Major Depressive Disorder (27)
5 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (189 evaluations)
Side effects
Nausea Weight gain 125 more
How many evaluations
291
Tried for
Major Depressive Disorder (499) Depressed mood (116)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (204 evaluations)
Side effects
Anxious mood Nausea 117 more
How many evaluations
260
Tried for
Major Depressive Disorder (481) Depressed mood (82)
6 more
Check to add this treatment to your profile
Treatment name(s)
Perceived effectiveness
for Major Depressive Disorder (108 evaluations)
Side effects
Anxious mood Anger 17 more
How many evaluations
136
Tried for
Major Depressive Disorder (454) Depressed mood (9)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (176 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 115 more
How many evaluations
216
Tried for
Major Depressive Disorder (395) Depressed mood (78)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (169 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 81 more
How many evaluations
203
Tried for
Major Depressive Disorder (376) Depressed mood (70)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (159 evaluations)
Side effects
Dry mouth Weight gain 111 more
How many evaluations
191
Tried for
Major Depressive Disorder (379) Depressed mood (75)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (141 evaluations)
Side effects
Nausea Anxious mood 96 more
How many evaluations
189
Tried for
Major Depressive Disorder (351) Depressed mood (74)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (111 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 76 more
How many evaluations
144
Tried for
Major Depressive Disorder (245) Depressed mood (52)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (106 evaluations)
Side effects
Drowsiness Sleepiness 41 more
How many evaluations
131
Tried for
Anxious mood (206) Insomnia (22)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (71 evaluations)
Side effects
Excessive daytime sleepiness (somnolence) Dizziness 42 more
How many evaluations
79
Tried for
Insomnia (146) Major Depressive Disorder (27)
5 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 224
20s 2,441
30s 3,615
40s 4,160
50s 3,507
60s 1,393
70+ 195

Sex

Distribution of sex

77% Female
23% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 3,971
20-29 years 1,580
30-39 years 1,063
40-49 years 582
50-59 years 187
60-69 years 19
70+ years 2

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 11,301
Not Diagnosed 1,963

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: