Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
733
Tried for
Major Depressive Disorder (692) Depressed mood (88)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
643
Tried for
Major Depressive Disorder (591) Depressed mood (123)
8 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
587
Tried for
Major Depressive Disorder (482) Depressed mood (216)
7 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
523
Tried for
Major Depressive Disorder (457) Depressed mood (157)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
516
Tried for
Major Depressive Disorder (512) Depressed mood (9)
5 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
479
Tried for
Major Depressive Disorder (405) Depressed mood (157)
3 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
362
Tried for
Major Depressive Disorder (345) Depressed mood (61)
2 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
358
Tried for
Major Depressive Disorder (325) Anxious mood (66)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
283
Tried for
Anxious mood (278) Insomnia (12)
3 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
216
Tried for
Insomnia (206) Major Depressive Disorder (23)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (362 evaluations)
Side effects
Anxious mood Headaches 161 more
How many evaluations
421
Tried for
Major Depressive Disorder (692) Depressed mood (88)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (310 evaluations)
Side effects
Dry mouth Nausea 133 more
How many evaluations
418
Tried for
Major Depressive Disorder (591) Depressed mood (123)
8 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (271 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 151 more
How many evaluations
371
Tried for
Major Depressive Disorder (482) Depressed mood (216)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (274 evaluations)
Side effects
Dry mouth Weight gain 148 more
How many evaluations
342
Tried for
Major Depressive Disorder (457) Depressed mood (157)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for Major Depressive Disorder (222 evaluations)
Side effects
Anxious mood Depressed mood 58 more
How many evaluations
270
Tried for
Major Depressive Disorder (513) Depressed mood (9)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (221 evaluations)
Side effects
Nausea Suicidal thoughts or urges 112 more
How many evaluations
282
Tried for
Major Depressive Disorder (405) Depressed mood (157)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (198 evaluations)
Side effects
Dry mouth Sleepiness 98 more
How many evaluations
230
Tried for
Major Depressive Disorder (345) Depressed mood (61)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (177 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 91 more
How many evaluations
216
Tried for
Major Depressive Disorder (325) Anxious mood (66)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (155 evaluations)
Side effects
Drowsiness Sleepiness 38 more
How many evaluations
172
Tried for
Anxious mood (278) Insomnia (12)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (103 evaluations)
Side effects
Dry mouth Drowsiness 46 more
How many evaluations
111
Tried for
Insomnia (206) Major Depressive Disorder (23)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 470
20s 3,944
30s 7,230
40s 9,601
50s 9,321
60s 4,400
70+ 674

Sex

Distribution of sex

76% Female
24% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 6,306
20-29 years 2,439
30-39 years 1,676
40-49 years 1,000
50-59 years 320
60-69 years 51
70+ years 6

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 15,935
Not Diagnosed 2,216

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: