Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
575
Tried for
Major Depressive Disorder (538) Depressed mood (77)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
530
Tried for
Major Depressive Disorder (479) Depressed mood (115)
8 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
514
Tried for
Major Depressive Disorder (421) Depressed mood (195)
6 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
450
Tried for
Major Depressive Disorder (391) Depressed mood (140)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
418
Tried for
Major Depressive Disorder (414) Depressed mood (9)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
405
Tried for
Major Depressive Disorder (336) Depressed mood (141)
3 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
310
Tried for
Major Depressive Disorder (295) Depressed mood (59)
2 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
299
Tried for
Major Depressive Disorder (269) Anxious mood (62)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
256
Tried for
Anxious mood (251) Insomnia (13)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
197
Tried for
Insomnia (188) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (265 evaluations)
Side effects
Anxious mood Irritability 141 more
How many evaluations
322
Tried for
Major Depressive Disorder (538) Depressed mood (77)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (234 evaluations)
Side effects
Dry mouth Nausea 114 more
How many evaluations
327
Tried for
Major Depressive Disorder (479) Depressed mood (115)
8 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (226 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 136 more
How many evaluations
314
Tried for
Major Depressive Disorder (421) Depressed mood (195)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (234 evaluations)
Side effects
Weight gain Dry mouth 139 more
How many evaluations
294
Tried for
Major Depressive Disorder (391) Depressed mood (140)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for Major Depressive Disorder (167 evaluations)
Side effects
Anxious mood Depressed mood 43 more
How many evaluations
206
Tried for
Major Depressive Disorder (414) Depressed mood (9)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (168 evaluations)
Side effects
Nausea Weight gain 100 more
How many evaluations
223
Tried for
Major Depressive Disorder (335) Depressed mood (140)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (162 evaluations)
Side effects
Loss of sex drive (libido) Sleepiness 88 more
How many evaluations
193
Tried for
Major Depressive Disorder (295) Depressed mood (59)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (142 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 85 more
How many evaluations
178
Tried for
Major Depressive Disorder (269) Anxious mood (62)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (134 evaluations)
Side effects
Drowsiness Sleepiness 35 more
How many evaluations
150
Tried for
Anxious mood (252) Insomnia (13)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (91 evaluations)
Side effects
Grogginess Drowsiness 40 more
How many evaluations
98
Tried for
Insomnia (188) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 351
20s 3,579
30s 6,443
40s 7,926
50s 7,206
60s 3,192
70+ 501

Sex

Distribution of sex

75% Female
25% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 5,547
20-29 years 2,133
30-39 years 1,447
40-49 years 828
50-59 years 255
60-69 years 34
70+ years 4

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 14,432
Not Diagnosed 2,139

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: