Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
840
Tried for
Major Depressive Disorder (797) Depressed mood (95)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
721
Tried for
Major Depressive Disorder (671) Depressed mood (125)
9 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
643
Tried for
Major Depressive Disorder (531) Depressed mood (232)
7 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
589
Tried for
Major Depressive Disorder (516) Depressed mood (173)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
571
Tried for
Major Depressive Disorder (566) Depressed mood (10)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
522
Tried for
Major Depressive Disorder (438) Depressed mood (175)
3 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
412
Tried for
Major Depressive Disorder (375) Anxious mood (75)
2 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
392
Tried for
Major Depressive Disorder (375) Depressed mood (63)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
308
Tried for
Anxious mood (302) Insomnia (13)
3 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
228
Tried for
Insomnia (217) Major Depressive Disorder (23)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (423 evaluations)
Side effects
Anxious mood Headaches 171 more
Total evaluations
482
Tried for
Major Depressive Disorder (797) Depressed mood (95)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (363 evaluations)
Side effects
Dry mouth Weight gain 145 more
Total evaluations
469
Tried for
Major Depressive Disorder (671) Depressed mood (125)
9 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (302 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 161 more
Total evaluations
408
Tried for
Major Depressive Disorder (531) Depressed mood (232)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (310 evaluations)
Side effects
Dry mouth Weight gain 155 more
Total evaluations
386
Tried for
Major Depressive Disorder (516) Depressed mood (173)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for Major Depressive Disorder (272 evaluations)
Side effects
Anxious mood Flashbacks 67 more
Total evaluations
326
Tried for
Major Depressive Disorder (566) Depressed mood (10)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (245 evaluations)
Side effects
Weight gain Suicidal thoughts or urges 127 more
Total evaluations
313
Tried for
Major Depressive Disorder (438) Depressed mood (175)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (217 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 99 more
Total evaluations
261
Tried for
Major Depressive Disorder (375) Anxious mood (75)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (217 evaluations)
Side effects
Sleepiness Dry mouth 100 more
Total evaluations
251
Tried for
Major Depressive Disorder (375) Depressed mood (63)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (172 evaluations)
Side effects
Drowsiness Sleepiness 43 more
Total evaluations
191
Tried for
Anxious mood (302) Insomnia (13)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (110 evaluations)
Side effects
Dry mouth Grogginess 50 more
Total evaluations
120
Tried for
Insomnia (217) Major Depressive Disorder (23)
4 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 546
20s 4,316
30s 8,006
40s 11,019
50s 10,787
60s 5,011
70+ 773
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 6,784
20-29 years 2,655
30-39 years 1,828
40-49 years 1,109
50-59 years 352
60-69 years 60
70+ years 6

Sex

Distribution of sex

77% Female
23% Male

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 16,887
Not Diagnosed 2,274

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: