Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
745
Tried for
major depressive disorder (703) depressed mood (87)
6 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
547
Tried for
major depressive disorder (509) depressed mood (89)
6 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
508
Tried for
major depressive disorder (502) anxious mood (9)
6 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
493
Tried for
major depressive disorder (424) depressed mood (152)
6 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
463
Tried for
major depressive disorder (406) depressed mood (133)
4 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
390
Tried for
major depressive disorder (333) depressed mood (123)
3 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
380
Tried for
major depressive disorder (333) anxious mood (83)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
234
Tried for
major depressive disorder (212) depressed mood (40)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
190
Tried for
anxious mood (187) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
165
Tried for
depressed mood (134) major depressive disorder (36)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (369 evaluations)
Side effects
anxious mood dry mouth 147 more
Total evaluations
433
Tried for
major depressive disorder (703) depressed mood (87)
6 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (287 evaluations)
Side effects
dry mouth weight gain 142 more
Total evaluations
361
Tried for
major depressive disorder (509) depressed mood (89)
6 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (266 evaluations)
Side effects
anxious mood flashbacks 54 more
Total evaluations
320
Tried for
major depressive disorder (502) anxious mood (9)
6 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (276 evaluations)
Side effects
decreased sex drive (libido) weight gain 150 more
Total evaluations
338
Tried for
major depressive disorder (424) depressed mood (152)
6 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (250 evaluations)
Side effects
dry mouth nausea 127 more
Total evaluations
306
Tried for
major depressive disorder (406) depressed mood (133)
4 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (205 evaluations)
Side effects
decreased sex drive (libido) nausea 100 more
Total evaluations
253
Tried for
major depressive disorder (333) depressed mood (123)
3 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (212 evaluations)
Side effects
decreased sex drive (libido) weight gain 94 more
Total evaluations
256
Tried for
major depressive disorder (333) anxious mood (83)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (122 evaluations)
Side effects
decreased sex drive (libido) dry mouth 72 more
Total evaluations
149
Tried for
major depressive disorder (212) depressed mood (40)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (116 evaluations)
Side effects
drowsiness sleepiness 30 more
Total evaluations
123
Tried for
anxious mood (187) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (91 evaluations)
Side effects
weight gain drowsiness 57 more
Total evaluations
128
Tried for
depressed mood (134) major depressive disorder (36)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 382
20s 4612
30s 9677
40s 14184
50s 15646
60s 8840
70+ 1840
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8729
20-29 years 3700
30-39 years 2705
40-49 years 1733
50-59 years 603
60-69 years 112
70+ years 18

Distribution of sex

Sex
Sex Proportion # of patients
Male 11562
Female 43889

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23684
Not Diagnosed 2336

These charts show data from MDD patients who have completed their condition history
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