Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
736
Tried for
major depressive disorder (694) depressed mood (87)
6 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
531
Tried for
major depressive disorder (496) depressed mood (85)
6 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
489
Tried for
major depressive disorder (483) anxious mood (9)
6 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
472
Tried for
major depressive disorder (403) depressed mood (148)
6 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
453
Tried for
major depressive disorder (396) depressed mood (129)
4 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
387
Tried for
major depressive disorder (334) depressed mood (117)
3 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
378
Tried for
major depressive disorder (333) anxious mood (85)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
226
Tried for
major depressive disorder (205) depressed mood (39)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
184
Tried for
anxious mood (181) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
162
Tried for
depressed mood (132) major depressive disorder (35)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
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Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (358 evaluations)
Side effects
anxious mood dry mouth 147 more
Total evaluations
423
Tried for
major depressive disorder (694) depressed mood (87)
6 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (281 evaluations)
Side effects
weight gain dry mouth 139 more
Total evaluations
346
Tried for
major depressive disorder (496) depressed mood (85)
6 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (253 evaluations)
Side effects
anxious mood flashbacks 54 more
Total evaluations
302
Tried for
major depressive disorder (483) anxious mood (9)
6 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (262 evaluations)
Side effects
decreased sex drive (libido) weight gain 144 more
Total evaluations
325
Tried for
major depressive disorder (403) depressed mood (148)
6 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (244 evaluations)
Side effects
dry mouth nausea 130 more
Total evaluations
300
Tried for
major depressive disorder (396) depressed mood (129)
4 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (204 evaluations)
Side effects
decreased sex drive (libido) nausea 100 more
Total evaluations
248
Tried for
major depressive disorder (334) depressed mood (117)
3 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (213 evaluations)
Side effects
decreased sex drive (libido) weight gain 103 more
Total evaluations
255
Tried for
major depressive disorder (333) anxious mood (85)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (115 evaluations)
Side effects
dry mouth decreased sex drive (libido) 68 more
Total evaluations
141
Tried for
major depressive disorder (205) depressed mood (39)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (105 evaluations)
Side effects
drowsiness sleepiness 24 more
Total evaluations
112
Tried for
anxious mood (181) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (88 evaluations)
Side effects
weight gain drowsiness 55 more
Total evaluations
124
Tried for
depressed mood (132) major depressive disorder (35)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 344
20s 4486
30s 9566
40s 14082
50s 15764
60s 9214
70+ 1976
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8745
20-29 years 3703
30-39 years 2707
40-49 years 1735
50-59 years 604
60-69 years 113
70+ years 18

Distribution of sex

Sex
Sex Proportion # of patients
Male 11620
Female 44082

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23724
Not Diagnosed 2334

These charts show data from MDD patients who have completed their condition history
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