Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
843
Tried for
major depressive disorder (804) Depressed mood (92)
6 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
672
Tried for
major depressive disorder (627) Depressed mood (126)
4 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
623
Tried for
major depressive disorder (522) Depressed mood (223)
6 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
608
Tried for
major depressive disorder (602) Anxious mood (10)
5 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
576
Tried for
major depressive disorder (508) Depressed mood (174)
6 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
538
Tried for
major depressive disorder (451) Depressed mood (186)
4 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
416
Tried for
major depressive disorder (375) Anxious mood (81)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
352
Tried for
major depressive disorder (336) Depressed mood (55)
3 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
283
Tried for
Anxious mood (278) Insomnia (13)
3 more
Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
221
Tried for
Insomnia (210) major depressive disorder (19)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (420 evaluations)
Side effects
Anxious mood Headaches 169 more
Total evaluations
480
Tried for
major depressive disorder (804) Depressed mood (92)
6 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (347 evaluations)
Side effects
Weight gain Dry mouth 138 more
Total evaluations
446
Tried for
major depressive disorder (626) Depressed mood (125)
4 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (304 evaluations)
Side effects
Decreased sex drive (libido) Weight gain 163 more
Total evaluations
400
Tried for
major depressive disorder (522) Depressed mood (223)
6 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (311 evaluations)
Side effects
Anxious mood Depressed mood 67 more
Total evaluations
373
Tried for
major depressive disorder (602) Anxious mood (10)
5 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (324 evaluations)
Side effects
Dry mouth Weight gain 156 more
Total evaluations
400
Tried for
major depressive disorder (508) Depressed mood (174)
6 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (242 evaluations)
Side effects
Weight gain Nausea 119 more
Total evaluations
316
Tried for
major depressive disorder (450) Depressed mood (186)
4 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (221 evaluations)
Side effects
Weight gain Decreased sex drive (libido) 96 more
Total evaluations
265
Tried for
major depressive disorder (375) Anxious mood (80)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (197 evaluations)
Side effects
Sleepiness Weight gain 96 more
Total evaluations
226
Tried for
major depressive disorder (336) Depressed mood (55)
3 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (157 evaluations)
Side effects
Drowsiness Sleepiness 42 more
Total evaluations
172
Tried for
Anxious mood (277) Insomnia (13)
3 more
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (104 evaluations)
Side effects
Dry mouth Drowsiness 49 more
Total evaluations
114
Tried for
Insomnia (211) major depressive disorder (19)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
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Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 533
20s 4,566
30s 8,746
40s 12,448
50s 12,494
60s 6,005
70+ 989
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 7,128
20-29 years 2,865
30-39 years 2,002
40-49 years 1,229
50-59 years 396
60-69 years 69
70+ years 7

Sex

Distribution of sex

78% Female
22% Male

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 17,772
Not Diagnosed 2,322

These charts show data from MDD patients who have completed their condition history
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