Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
856
Tried for
major depressive disorder (810) depressed mood (97)
5 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
633
Tried for
major depressive disorder (590) depressed mood (111)
6 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
568
Tried for
major depressive disorder (562) anxious mood (10)
6 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
561
Tried for
major depressive disorder (475) depressed mood (182)
6 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
559
Tried for
major depressive disorder (490) depressed mood (162)
5 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
474
Tried for
major depressive disorder (399) depressed mood (157)
2 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
428
Tried for
major depressive disorder (377) anxious mood (91)
3 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
287
Tried for
major depressive disorder (265) depressed mood (45)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
244
Tried for
anxious mood (241) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
181
Tried for
depressed mood (147) major depressive disorder (42)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (418 evaluations)
Side effects
anxious mood dry mouth 163 more
Total evaluations
479
Tried for
major depressive disorder (810) depressed mood (97)
5 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (335 evaluations)
Side effects
dry mouth weight gain 155 more
Total evaluations
427
Tried for
major depressive disorder (590) depressed mood (111)
6 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (297 evaluations)
Side effects
anxious mood depressed mood 57 more
Total evaluations
353
Tried for
major depressive disorder (562) anxious mood (10)
6 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (295 evaluations)
Side effects
decreased sex drive (libido) weight gain 159 more
Total evaluations
376
Tried for
major depressive disorder (475) depressed mood (182)
6 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (299 evaluations)
Side effects
dry mouth nausea 145 more
Total evaluations
370
Tried for
major depressive disorder (490) depressed mood (162)
5 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (231 evaluations)
Side effects
nausea decreased sex drive (libido) 112 more
Total evaluations
295
Tried for
major depressive disorder (399) depressed mood (157)
2 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (236 evaluations)
Side effects
decreased sex drive (libido) weight gain 99 more
Total evaluations
284
Tried for
major depressive disorder (377) anxious mood (91)
3 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (156 evaluations)
Side effects
dry mouth decreased sex drive (libido) 83 more
Total evaluations
184
Tried for
major depressive disorder (265) depressed mood (45)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (139 evaluations)
Side effects
drowsiness sleepiness 35 more
Total evaluations
146
Tried for
anxious mood (241) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (96 evaluations)
Side effects
weight gain drowsiness 59 more
Total evaluations
135
Tried for
depressed mood (147) major depressive disorder (42)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 425
20s 4752
30s 9779
40s 14251
50s 15539
60s 8570
70+ 1702
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8722
20-29 years 3711
30-39 years 2709
40-49 years 1731
50-59 years 605
60-69 years 110
70+ years 18

Distribution of sex

Sex
Sex Proportion # of patients
Male 11529
Female 43749

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23688
Not Diagnosed 2343

These charts show data from MDD patients who have completed their condition history
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