Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
862
Tried for
major depressive disorder (821) depressed mood (95)
6 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
679
Tried for
major depressive disorder (632) depressed mood (132)
3 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
632
Tried for
major depressive disorder (527) depressed mood (229)
5 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
610
Tried for
major depressive disorder (604) anxious mood (9)
4 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
586
Tried for
major depressive disorder (518) depressed mood (177)
5 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
543
Tried for
major depressive disorder (459) depressed mood (186)
3 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
426
Tried for
major depressive disorder (384) anxious mood (82)
1 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
354
Tried for
major depressive disorder (338) depressed mood (54)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
281
Tried for
anxious mood (279) major depressive disorder (5)
2 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
172
Tried for
depressed mood (139) major depressive disorder (38)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
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Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (426 evaluations)
Side effects
anxious mood headaches 171 more
Total evaluations
487
Tried for
major depressive disorder (821) depressed mood (95)
6 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (347 evaluations)
Side effects
weight gain dry mouth 138 more
Total evaluations
453
Tried for
major depressive disorder (632) depressed mood (132)
3 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (302 evaluations)
Side effects
sex drive (libido) decreased weight gain 162 more
Total evaluations
400
Tried for
major depressive disorder (527) depressed mood (229)
5 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (314 evaluations)
Side effects
anxious mood depressed mood 67 more
Total evaluations
376
Tried for
major depressive disorder (604) anxious mood (9)
4 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (329 evaluations)
Side effects
dry mouth weight gain 156 more
Total evaluations
405
Tried for
major depressive disorder (518) depressed mood (177)
5 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (246 evaluations)
Side effects
weight gain nausea 116 more
Total evaluations
322
Tried for
major depressive disorder (459) depressed mood (186)
3 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (222 evaluations)
Side effects
weight gain sex drive (libido) decreased 93 more
Total evaluations
265
Tried for
major depressive disorder (384) anxious mood (82)
1 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (201 evaluations)
Side effects
sleepiness dry mouth 96 more
Total evaluations
230
Tried for
major depressive disorder (338) depressed mood (54)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (159 evaluations)
Side effects
drowsiness sleepiness 42 more
Total evaluations
169
Tried for
anxious mood (279) major depressive disorder (5)
2 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (84 evaluations)
Side effects
weight gain nausea 69 more
Total evaluations
128
Tried for
depressed mood (139) major depressive disorder (38)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
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Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 530
20s 4,679
30s 9,025
40s 12,943
50s 13,073
60s 6,363
70+ 1,055
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 7,524
20-29 years 3,124
30-39 years 2,190
40-49 years 1,371
50-59 years 462
60-69 years 84
70+ years 9

Sex

Distribution of sex

78% Female
22% Male

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 18,857
Not Diagnosed 2,376

These charts show data from MDD patients who have completed their condition history
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