Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
569
Tried for
Major Depressive Disorder (529) Depressed mood (82)
6 more
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Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
529
Tried for
Major Depressive Disorder (481) Depressed mood (114)
7 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
481
Tried for
Major Depressive Disorder (402) Depressed mood (159)
6 more
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Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
423
Tried for
Major Depressive Disorder (419) Depressed mood (8)
6 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
423
Tried for
Major Depressive Disorder (372) Depressed mood (125)
3 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
385
Tried for
Major Depressive Disorder (331) Depressed mood (122)
4 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
318
Tried for
Major Depressive Disorder (300) Depressed mood (58)
2 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
286
Tried for
Major Depressive Disorder (256) Anxious mood (63)
2 more
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Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
265
Tried for
Anxious mood (258) Insomnia (16)
2 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
197
Tried for
Insomnia (187) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (235 evaluations)
Side effects
Anxious mood Irritability 128 more
How many evaluations
290
Tried for
Major Depressive Disorder (529) Depressed mood (82)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (221 evaluations)
Side effects
Nausea Dry mouth 115 more
How many evaluations
307
Tried for
Major Depressive Disorder (481) Depressed mood (114)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (210 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 122 more
How many evaluations
276
Tried for
Major Depressive Disorder (402) Depressed mood (159)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for Major Depressive Disorder (146 evaluations)
Side effects
Anxious mood Depressed mood 39 more
How many evaluations
182
Tried for
Major Depressive Disorder (419) Depressed mood (8)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (214 evaluations)
Side effects
Dry mouth Weight gain 141 more
How many evaluations
261
Tried for
Major Depressive Disorder (372) Depressed mood (125)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (150 evaluations)
Side effects
Vivid dreams Weight gain 98 more
How many evaluations
198
Tried for
Major Depressive Disorder (331) Depressed mood (122)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (156 evaluations)
Side effects
Headaches Sleepiness 88 more
How many evaluations
189
Tried for
Major Depressive Disorder (300) Depressed mood (58)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (125 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 79 more
How many evaluations
161
Tried for
Major Depressive Disorder (256) Anxious mood (63)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (126 evaluations)
Side effects
Drowsiness Sleepiness 40 more
How many evaluations
146
Tried for
Anxious mood (258) Insomnia (16)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (89 evaluations)
Side effects
Grogginess Fatigue 43 more
How many evaluations
96
Tried for
Insomnia (187) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 386
20s 3,524
30s 6,154
40s 7,468
50s 6,597
60s 2,851
70+ 424

Sex

Distribution of sex

76% Female
24% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 5,396
20-29 years 2,058
30-39 years 1,400
40-49 years 804
50-59 years 232
60-69 years 31
70+ years 4

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 14,073
Not Diagnosed 2,116

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: