Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
553
Tried for
Major Depressive Disorder (514) Depressed mood (79)
6 more
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Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
526
Tried for
Major Depressive Disorder (477) Depressed mood (115)
7 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
475
Tried for
Major Depressive Disorder (399) Depressed mood (152)
7 more
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Treatment name(s)
Type
Psychotherapy
How many have tried
428
Tried for
Major Depressive Disorder (424) Depressed mood (7)
6 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
411
Tried for
Major Depressive Disorder (358) Depressed mood (115)
3 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
380
Tried for
Major Depressive Disorder (328) Depressed mood (113)
4 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
325
Tried for
Major Depressive Disorder (305) Depressed mood (58)
2 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
274
Tried for
Major Depressive Disorder (244) Anxious mood (56)
1 more
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Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
260
Tried for
Anxious mood (250) Insomnia (18)
3 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
190
Tried for
Insomnia (179) Major Depressive Disorder (23)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (221 evaluations)
Side effects
Anxious mood Irritability 127 more
How many evaluations
266
Tried for
Major Depressive Disorder (514) Depressed mood (79)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (208 evaluations)
Side effects
Nausea Weight gain 116 more
How many evaluations
295
Tried for
Major Depressive Disorder (477) Depressed mood (115)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (207 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 116 more
How many evaluations
269
Tried for
Major Depressive Disorder (399) Depressed mood (152)
7 more
Check to add this treatment to your profile
Treatment name(s)
Perceived effectiveness
for Major Depressive Disorder (135 evaluations)
Side effects
Anxious mood Anxiety and frustration 31 more
How many evaluations
162
Tried for
Major Depressive Disorder (424) Depressed mood (7)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (198 evaluations)
Side effects
Dry mouth Weight gain 134 more
How many evaluations
241
Tried for
Major Depressive Disorder (358) Depressed mood (115)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (150 evaluations)
Side effects
Nausea Vivid dreams 97 more
How many evaluations
200
Tried for
Major Depressive Disorder (328) Depressed mood (113)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (155 evaluations)
Side effects
Sleepiness Headaches 81 more
How many evaluations
189
Tried for
Major Depressive Disorder (305) Depressed mood (58)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (120 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 77 more
How many evaluations
155
Tried for
Major Depressive Disorder (244) Anxious mood (56)
1 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (121 evaluations)
Side effects
Drowsiness Sleepiness 44 more
How many evaluations
143
Tried for
Anxious mood (250) Insomnia (18)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (87 evaluations)
Side effects
Grogginess Drowsy in a.m. 40 more
How many evaluations
94
Tried for
Insomnia (179) Major Depressive Disorder (23)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 376
20s 3,523
30s 5,986
40s 7,300
50s 6,493
60s 2,768
70+ 417

Sex

Distribution of sex

77% Female
23% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 5,299
20-29 years 2,051
30-39 years 1,378
40-49 years 790
50-59 years 228
60-69 years 30
70+ years 3

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 13,901
Not Diagnosed 2,103

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: