Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
568
Tried for
Major Depressive Disorder (527) Depressed mood (84)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
528
Tried for
Major Depressive Disorder (479) Depressed mood (116)
7 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
480
Tried for
Major Depressive Disorder (404) Depressed mood (159)
6 more
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Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
432
Tried for
Major Depressive Disorder (428) Depressed mood (8)
6 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
421
Tried for
Major Depressive Disorder (368) Depressed mood (123)
3 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
388
Tried for
Major Depressive Disorder (332) Depressed mood (121)
4 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
320
Tried for
Major Depressive Disorder (302) Depressed mood (59)
2 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
285
Tried for
Major Depressive Disorder (255) Anxious mood (61)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
266
Tried for
Anxious mood (258) Insomnia (17)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
197
Tried for
Insomnia (187) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (236 evaluations)
Side effects
Anxious mood Irritability 129 more
How many evaluations
288
Tried for
Major Depressive Disorder (527) Depressed mood (84)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (217 evaluations)
Side effects
Nausea Dry mouth 115 more
How many evaluations
304
Tried for
Major Depressive Disorder (479) Depressed mood (116)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (210 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 119 more
How many evaluations
273
Tried for
Major Depressive Disorder (404) Depressed mood (159)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for Major Depressive Disorder (147 evaluations)
Side effects
Anxious mood Depressed mood 34 more
How many evaluations
179
Tried for
Major Depressive Disorder (428) Depressed mood (8)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (209 evaluations)
Side effects
Dry mouth Weight gain 140 more
How many evaluations
255
Tried for
Major Depressive Disorder (368) Depressed mood (123)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (150 evaluations)
Side effects
Vivid dreams Anxious mood 98 more
How many evaluations
200
Tried for
Major Depressive Disorder (332) Depressed mood (121)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (160 evaluations)
Side effects
Headaches Sex drive (libido) decreased 86 more
How many evaluations
193
Tried for
Major Depressive Disorder (302) Depressed mood (59)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (123 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 78 more
How many evaluations
159
Tried for
Major Depressive Disorder (255) Anxious mood (61)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (126 evaluations)
Side effects
Drowsiness Sleepiness 40 more
How many evaluations
147
Tried for
Anxious mood (258) Insomnia (17)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (90 evaluations)
Side effects
Grogginess Drowsy in a.m. 43 more
How many evaluations
97
Tried for
Insomnia (187) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 374
20s 3,518
30s 6,065
40s 7,382
50s 6,572
60s 2,838
70+ 426

Sex

Distribution of sex

76% Female
24% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 5,348
20-29 years 2,077
30-39 years 1,395
40-49 years 802
50-59 years 234
60-69 years 31
70+ years 4

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 14,029
Not Diagnosed 2,118

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: