Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
731
Tried for
major depressive disorder (684) depressed mood (89)
7 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
522
Tried for
major depressive disorder (487) depressed mood (81)
6 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
453
Tried for
major depressive disorder (392) depressed mood (132)
6 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
451
Tried for
major depressive disorder (446) anxious mood (8)
6 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
436
Tried for
major depressive disorder (383) depressed mood (118)
4 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
371
Tried for
major depressive disorder (324) depressed mood (105)
3 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
359
Tried for
major depressive disorder (317) anxious mood (90)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
208
Tried for
major depressive disorder (192) depressed mood (31)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
172
Tried for
anxious mood (168) major depressive disorder (3)
4 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
152
Tried for
depressed mood (122) major depressive disorder (35)
2 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (367 evaluations)
Side effects
anxious mood dry mouth 153 more
Total evaluations
438
Tried for
major depressive disorder (684) depressed mood (89)
7 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (280 evaluations)
Side effects
dry mouth weight gain 135 more
Total evaluations
343
Tried for
major depressive disorder (487) depressed mood (81)
6 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (261 evaluations)
Side effects
decreased sex drive (libido) weight gain 136 more
Total evaluations
316
Tried for
major depressive disorder (392) depressed mood (132)
6 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (235 evaluations)
Side effects
anxious mood flashbacks 45 more
Total evaluations
282
Tried for
major depressive disorder (446) anxious mood (8)
6 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (241 evaluations)
Side effects
nausea dry mouth 126 more
Total evaluations
290
Tried for
major depressive disorder (383) depressed mood (118)
4 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (193 evaluations)
Side effects
nausea decreased sex drive (libido) 91 more
Total evaluations
232
Tried for
major depressive disorder (324) depressed mood (105)
3 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (175 evaluations)
Side effects
decreased sex drive (libido) weight gain 98 more
Total evaluations
213
Tried for
major depressive disorder (317) anxious mood (90)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (110 evaluations)
Side effects
nausea dry mouth 52 more
Total evaluations
126
Tried for
major depressive disorder (192) depressed mood (31)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (84 evaluations)
Side effects
drowsiness tiredness 21 more
Total evaluations
91
Tried for
anxious mood (168) major depressive disorder (3)
4 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (82 evaluations)
Side effects
weight gain drowsiness 56 more
Total evaluations
119
Tried for
depressed mood (122) major depressive disorder (35)
2 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 323
20s 4285
30s 9485
40s 14326
50s 16801
60s 10433
70+ 2367
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8806
20-29 years 3723
30-39 years 2724
40-49 years 1747
50-59 years 609
60-69 years 114
70+ years 19

Distribution of sex

Sex
Sex Proportion # of patients
Male 12030
Female 46297

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23873
Not Diagnosed 2332

These charts show data from MDD patients who have completed their condition history
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