Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
860
Tried for
major depressive disorder (814) depressed mood (97)
5 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
630
Tried for
major depressive disorder (588) depressed mood (113)
6 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
582
Tried for
major depressive disorder (576) anxious mood (10)
6 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
567
Tried for
major depressive disorder (479) depressed mood (192)
4 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
558
Tried for
major depressive disorder (490) depressed mood (165)
5 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
487
Tried for
major depressive disorder (408) depressed mood (166)
2 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
422
Tried for
major depressive disorder (373) anxious mood (89)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
294
Tried for
major depressive disorder (275) depressed mood (46)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
255
Tried for
anxious mood (253) major depressive disorder (3)
2 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
182
Tried for
depressed mood (147) major depressive disorder (42)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (420 evaluations)
Side effects
anxious mood dry mouth 165 more
Total evaluations
483
Tried for
major depressive disorder (814) depressed mood (97)
5 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (337 evaluations)
Side effects
dry mouth weight gain 159 more
Total evaluations
433
Tried for
major depressive disorder (588) depressed mood (113)
6 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (301 evaluations)
Side effects
anxious mood depressed mood 54 more
Total evaluations
359
Tried for
major depressive disorder (576) anxious mood (10)
6 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (293 evaluations)
Side effects
decreased sex drive (libido) weight gain 149 more
Total evaluations
378
Tried for
major depressive disorder (479) depressed mood (192)
4 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (301 evaluations)
Side effects
dry mouth nausea 145 more
Total evaluations
368
Tried for
major depressive disorder (490) depressed mood (165)
5 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (234 evaluations)
Side effects
weight gain decreased sex drive (libido) 108 more
Total evaluations
300
Tried for
major depressive disorder (408) depressed mood (166)
2 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (238 evaluations)
Side effects
decreased sex drive (libido) weight gain 97 more
Total evaluations
285
Tried for
major depressive disorder (373) anxious mood (89)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (161 evaluations)
Side effects
dry mouth decreased sex drive (libido) 82 more
Total evaluations
189
Tried for
major depressive disorder (275) depressed mood (46)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (141 evaluations)
Side effects
drowsiness sleepiness 35 more
Total evaluations
148
Tried for
anxious mood (253) major depressive disorder (3)
2 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (93 evaluations)
Side effects
weight gain nausea 59 more
Total evaluations
134
Tried for
depressed mood (147) major depressive disorder (42)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 436
20s 4795
30s 9664
40s 14025
50s 14950
60s 8022
70+ 1552
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8649
20-29 years 3695
30-39 years 2698
40-49 years 1721
50-59 years 603
60-69 years 110
70+ years 17

Distribution of sex

Sex
Sex Proportion # of patients
Male 11248
Female 42430

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23505
Not Diagnosed 2338

These charts show data from MDD patients who have completed their condition history
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