Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
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Treatments taken by people for major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin)
Type
Prescription Drug
How many have tried
15738
Tried for
major depressive disorder (539)
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
23181
Tried for
major depressive disorder (374)
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
11643
Tried for
major depressive disorder (362)
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
15331
Tried for
major depressive disorder (320)
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
18816
Tried for
major depressive disorder (313)
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
10293
Tried for
major depressive disorder (264)
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
18119
Tried for
major depressive disorder (255)
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
10663
Tried for
major depressive disorder (149)

Data from patients with major depressive disorder, who have ever reported treatments, ordered by their reporting frequency during the last 5 years.
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Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin)
Perceived effectiveness
for major depressive disorder (294 evaluations)
Side effects
dry mouth headaches 139 more
Total evaluations
324
Tried for
major depressive disorder (539)
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (193 evaluations)
Side effects
anxious mood flashbacks 38 more
Total evaluations
224
Tried for
major depressive disorder (374)
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (206 evaluations)
Side effects
dry mouth weight gain 109 more
Total evaluations
229
Tried for
major depressive disorder (362)
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (225 evaluations)
Side effects
dry mouth nausea 116 more
Total evaluations
241
Tried for
major depressive disorder (320)
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (210 evaluations)
Side effects
weight gain decreased sex drive (libido) 101 more
Total evaluations
223
Tried for
major depressive disorder (313)
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (154 evaluations)
Side effects
decreased sex drive (libido) dry mouth 83 more
Total evaluations
156
Tried for
major depressive disorder (264)
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (153 evaluations)
Side effects
nausea decreased sex drive (libido) 76 more
Total evaluations
164
Tried for
major depressive disorder (255)
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (89 evaluations)
Side effects
nausea dizziness 44 more
Total evaluations
92
Tried for
major depressive disorder (149)
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who have ever reported treatments, ordered by their reporting frequency during the last 5 years.
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Who has major depressive disorder on PatientsLikeMe?

  • 47 new patients joined this month
  • 31706 say MDD is their primary condition

Age
Age Proportion # of patients
<20 249
20s 4105
30s 9254
40s 14006
50s 16890
60s 11008
70+ 2645
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8822
20-29 years 3725
30-39 years 2727
40-49 years 1749
50-59 years 611
60-69 years 114
70+ years 19

Distribution of sex

Sex
Sex Proportion # of patients
Male 12055
Female 46407

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23901
Not Diagnosed 2334

These charts show data from MDD patients who have completed their condition history
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