Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
854
Tried for
major depressive disorder (808) depressed mood (99)
5 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
633
Tried for
major depressive disorder (591) depressed mood (112)
6 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
583
Tried for
major depressive disorder (577) anxious mood (10)
6 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
570
Tried for
major depressive disorder (483) depressed mood (193)
4 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
558
Tried for
major depressive disorder (489) depressed mood (167)
5 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
490
Tried for
major depressive disorder (413) depressed mood (165)
2 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
412
Tried for
major depressive disorder (366) anxious mood (84)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
308
Tried for
major depressive disorder (287) depressed mood (48)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
261
Tried for
anxious mood (259) irritability (3)
2 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
178
Tried for
depressed mood (144) major depressive disorder (40)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (416 evaluations)
Side effects
anxious mood dry mouth 165 more
Total evaluations
478
Tried for
major depressive disorder (808) depressed mood (99)
5 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (333 evaluations)
Side effects
weight gain dry mouth 163 more
Total evaluations
437
Tried for
major depressive disorder (591) depressed mood (112)
6 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (297 evaluations)
Side effects
anxious mood flashbacks 53 more
Total evaluations
355
Tried for
major depressive disorder (577) anxious mood (10)
6 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (299 evaluations)
Side effects
decreased sex drive (libido) weight gain 154 more
Total evaluations
380
Tried for
major depressive disorder (483) depressed mood (193)
4 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (306 evaluations)
Side effects
dry mouth decreased sex drive (libido) 148 more
Total evaluations
373
Tried for
major depressive disorder (489) depressed mood (167)
5 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (237 evaluations)
Side effects
weight gain nausea 111 more
Total evaluations
301
Tried for
major depressive disorder (413) depressed mood (165)
2 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (232 evaluations)
Side effects
decreased sex drive (libido) weight gain 94 more
Total evaluations
278
Tried for
major depressive disorder (366) anxious mood (84)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (167 evaluations)
Side effects
dry mouth decreased sex drive (libido) 84 more
Total evaluations
195
Tried for
major depressive disorder (287) depressed mood (48)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (148 evaluations)
Side effects
drowsiness sleepiness 38 more
Total evaluations
156
Tried for
anxious mood (259) irritability (3)
2 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (99 evaluations)
Side effects
weight gain nausea 58 more
Total evaluations
139
Tried for
depressed mood (144) major depressive disorder (40)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
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Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 463
20s 4,814
30s 9,668
40s 13,910
50s 14,733
60s 7,728
70+ 1,446
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8,568
20-29 years 3,662
30-39 years 2,662
40-49 years 1,692
50-59 years 597
60-69 years 109
70+ years 17

Distribution of sex

Sex
Sex Proportion # of patients
Male 11,139
Female 41,846

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23,191
Not Diagnosed 2,331

These charts show data from MDD patients who have completed their condition history
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