Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
898
Tried for
major depressive disorder (851) depressed mood (100)
6 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
698
Tried for
major depressive disorder (650) depressed mood (136)
3 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
649
Tried for
major depressive disorder (545) depressed mood (231)
5 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
622
Tried for
major depressive disorder (616) anxious mood (10)
4 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
610
Tried for
major depressive disorder (536) depressed mood (186)
5 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
556
Tried for
major depressive disorder (472) depressed mood (186)
4 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
451
Tried for
major depressive disorder (406) anxious mood (85)
1 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
359
Tried for
major depressive disorder (341) depressed mood (54)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
288
Tried for
anxious mood (285) major depressive disorder (6)
3 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
184
Tried for
depressed mood (148) major depressive disorder (41)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
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Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (439 evaluations)
Side effects
anxious mood headaches 173 more
Total evaluations
503
Tried for
major depressive disorder (851) depressed mood (100)
6 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (351 evaluations)
Side effects
dry mouth weight gain 165 more
Total evaluations
467
Tried for
major depressive disorder (650) depressed mood (136)
3 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (313 evaluations)
Side effects
decreased sex drive (libido) weight gain 165 more
Total evaluations
412
Tried for
major depressive disorder (545) depressed mood (231)
5 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (311 evaluations)
Side effects
anxious mood depressed mood 65 more
Total evaluations
375
Tried for
major depressive disorder (616) anxious mood (10)
4 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (334 evaluations)
Side effects
dry mouth weight gain 158 more
Total evaluations
411
Tried for
major depressive disorder (536) depressed mood (186)
5 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (250 evaluations)
Side effects
weight gain nausea 118 more
Total evaluations
326
Tried for
major depressive disorder (472) depressed mood (186)
4 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (234 evaluations)
Side effects
weight gain decreased sex drive (libido) 97 more
Total evaluations
281
Tried for
major depressive disorder (406) anxious mood (85)
1 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (201 evaluations)
Side effects
sleepiness dry mouth 96 more
Total evaluations
230
Tried for
major depressive disorder (341) depressed mood (54)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (166 evaluations)
Side effects
drowsiness sleepiness 41 more
Total evaluations
177
Tried for
anxious mood (285) major depressive disorder (6)
3 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (91 evaluations)
Side effects
weight gain nausea 72 more
Total evaluations
136
Tried for
depressed mood (148) major depressive disorder (41)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
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Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 585
20s 4,959
30s 9,558
40s 13,708
50s 13,911
60s 6,823
70+ 1,148
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8,174
20-29 years 3,476
30-39 years 2,510
40-49 years 1,591
50-59 years 549
60-69 years 107
70+ years 15

Sex

Distribution of sex

79% Female
21% Male

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 20,601
Not Diagnosed 2,469

These charts show data from MDD patients who have completed their condition history
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