Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
652
Tried for
Major Depressive Disorder (611) Depressed mood (81)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
598
Tried for
Major Depressive Disorder (546) Depressed mood (121)
8 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
548
Tried for
Major Depressive Disorder (448) Depressed mood (205)
6 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
484
Tried for
Major Depressive Disorder (420) Depressed mood (148)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
474
Tried for
Major Depressive Disorder (470) Depressed mood (9)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
444
Tried for
Major Depressive Disorder (371) Depressed mood (149)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
343
Tried for
Major Depressive Disorder (326) Depressed mood (61)
2 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
325
Tried for
Major Depressive Disorder (293) Anxious mood (64)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
273
Tried for
Anxious mood (268) Insomnia (12)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
206
Tried for
Insomnia (197) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (315 evaluations)
Side effects
Anxious mood Irritability 151 more
How many evaluations
374
Tried for
Major Depressive Disorder (611) Depressed mood (81)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (284 evaluations)
Side effects
Dry mouth Nausea 122 more
How many evaluations
383
Tried for
Major Depressive Disorder (545) Depressed mood (121)
8 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (251 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 139 more
How many evaluations
343
Tried for
Major Depressive Disorder (448) Depressed mood (205)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (251 evaluations)
Side effects
Dry mouth Weight gain 145 more
How many evaluations
314
Tried for
Major Depressive Disorder (420) Depressed mood (148)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for Major Depressive Disorder (202 evaluations)
Side effects
Anxious mood Depressed mood 52 more
How many evaluations
244
Tried for
Major Depressive Disorder (469) Depressed mood (9)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (191 evaluations)
Side effects
Nausea Weight gain 108 more
How many evaluations
249
Tried for
Major Depressive Disorder (371) Depressed mood (149)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (186 evaluations)
Side effects
Dry mouth Loss of sex drive (libido) 97 more
How many evaluations
217
Tried for
Major Depressive Disorder (326) Depressed mood (61)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (159 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 90 more
How many evaluations
199
Tried for
Major Depressive Disorder (292) Anxious mood (64)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (146 evaluations)
Side effects
Drowsiness Sleepiness 37 more
How many evaluations
163
Tried for
Anxious mood (268) Insomnia (12)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (98 evaluations)
Side effects
Drowsiness Dry mouth 43 more
How many evaluations
105
Tried for
Insomnia (197) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 391
20s 3,726
30s 6,845
40s 8,789
50s 8,422
60s 3,931
70+ 613

Sex

Distribution of sex

76% Female
24% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 5,971
20-29 years 2,301
30-39 years 1,576
40-49 years 935
50-59 years 294
60-69 years 47
70+ years 5

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 15,303
Not Diagnosed 2,182

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: