Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
658
Tried for
Major Depressive Disorder (617) Depressed mood (81)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
603
Tried for
Major Depressive Disorder (550) Depressed mood (122)
8 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
550
Tried for
Major Depressive Disorder (449) Depressed mood (206)
6 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
487
Tried for
Major Depressive Disorder (421) Depressed mood (150)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
475
Tried for
Major Depressive Disorder (471) Depressed mood (9)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
447
Tried for
Major Depressive Disorder (374) Depressed mood (149)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
344
Tried for
Major Depressive Disorder (327) Depressed mood (61)
2 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
325
Tried for
Major Depressive Disorder (293) Anxious mood (64)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
274
Tried for
Anxious mood (269) Insomnia (12)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
208
Tried for
Insomnia (199) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (319 evaluations)
Side effects
Anxious mood Irritability 151 more
How many evaluations
378
Tried for
Major Depressive Disorder (616) Depressed mood (81)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (289 evaluations)
Side effects
Dry mouth Nausea 125 more
How many evaluations
388
Tried for
Major Depressive Disorder (550) Depressed mood (122)
8 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (254 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 139 more
How many evaluations
347
Tried for
Major Depressive Disorder (449) Depressed mood (206)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (251 evaluations)
Side effects
Dry mouth Weight gain 145 more
How many evaluations
315
Tried for
Major Depressive Disorder (421) Depressed mood (150)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for Major Depressive Disorder (204 evaluations)
Side effects
Anxious mood Depressed mood 52 more
How many evaluations
246
Tried for
Major Depressive Disorder (471) Depressed mood (9)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (194 evaluations)
Side effects
Nausea Weight gain 108 more
How many evaluations
252
Tried for
Major Depressive Disorder (374) Depressed mood (149)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (186 evaluations)
Side effects
Dry mouth Loss of sex drive (libido) 97 more
How many evaluations
217
Tried for
Major Depressive Disorder (327) Depressed mood (61)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (158 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 90 more
How many evaluations
198
Tried for
Major Depressive Disorder (293) Anxious mood (64)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (147 evaluations)
Side effects
Drowsiness Sleepiness 37 more
How many evaluations
164
Tried for
Anxious mood (269) Insomnia (12)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (98 evaluations)
Side effects
Drowsiness Dry mouth 43 more
How many evaluations
105
Tried for
Insomnia (199) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 402
20s 3,737
30s 6,877
40s 8,847
50s 8,478
60s 3,968
70+ 617

Sex

Distribution of sex

76% Female
24% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 6,001
20-29 years 2,314
30-39 years 1,580
40-49 years 945
50-59 years 295
60-69 years 47
70+ years 5

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 15,357
Not Diagnosed 2,186

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: