Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
585
Tried for
Major Depressive Disorder (548) Depressed mood (77)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
536
Tried for
Major Depressive Disorder (485) Depressed mood (115)
8 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
518
Tried for
Major Depressive Disorder (422) Depressed mood (198)
6 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
455
Tried for
Major Depressive Disorder (396) Depressed mood (140)
4 more
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Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
418
Tried for
Major Depressive Disorder (414) Depressed mood (9)
5 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
408
Tried for
Major Depressive Disorder (339) Depressed mood (140)
3 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
317
Tried for
Major Depressive Disorder (302) Depressed mood (60)
2 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
304
Tried for
Major Depressive Disorder (274) Anxious mood (62)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
257
Tried for
Anxious mood (252) Insomnia (13)
3 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
197
Tried for
Insomnia (188) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (268 evaluations)
Side effects
Anxious mood Headaches 145 more
How many evaluations
325
Tried for
Major Depressive Disorder (549) Depressed mood (77)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (241 evaluations)
Side effects
Dry mouth Nausea 116 more
How many evaluations
334
Tried for
Major Depressive Disorder (490) Depressed mood (116)
8 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (231 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 139 more
How many evaluations
320
Tried for
Major Depressive Disorder (423) Depressed mood (198)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (236 evaluations)
Side effects
Weight gain Dry mouth 140 more
How many evaluations
297
Tried for
Major Depressive Disorder (397) Depressed mood (142)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for Major Depressive Disorder (169 evaluations)
Side effects
Anxious mood Depressed mood 45 more
How many evaluations
208
Tried for
Major Depressive Disorder (415) Depressed mood (9)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (169 evaluations)
Side effects
Nausea Weight gain 100 more
How many evaluations
224
Tried for
Major Depressive Disorder (340) Depressed mood (140)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (168 evaluations)
Side effects
Loss of sex drive (libido) Sleepiness 90 more
How many evaluations
199
Tried for
Major Depressive Disorder (301) Depressed mood (60)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (146 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 85 more
How many evaluations
182
Tried for
Major Depressive Disorder (274) Anxious mood (62)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (137 evaluations)
Side effects
Drowsiness Sleepiness 35 more
How many evaluations
153
Tried for
Anxious mood (253) Insomnia (13)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (91 evaluations)
Side effects
Grogginess Drowsiness 40 more
How many evaluations
98
Tried for
Insomnia (188) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 347
20s 3,595
30s 6,460
40s 8,000
50s 7,304
60s 3,274
70+ 519

Sex

Distribution of sex

75% Female
25% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 5,583
20-29 years 2,145
30-39 years 1,453
40-49 years 833
50-59 years 260
60-69 years 35
70+ years 5

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 14,513
Not Diagnosed 2,141

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: