Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
571
Tried for
Major Depressive Disorder (533) Depressed mood (79)
6 more
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Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
561
Tried for
Major Depressive Disorder (510) Depressed mood (117)
7 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
470
Tried for
Major Depressive Disorder (405) Depressed mood (131)
6 more
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Treatment name(s)
Type
Psychotherapy
How many have tried
446
Tried for
Major Depressive Disorder (441) Depressed mood (6)
6 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
434
Tried for
Major Depressive Disorder (384) Depressed mood (108)
4 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
399
Tried for
Major Depressive Disorder (350) Depressed mood (111)
5 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
360
Tried for
Major Depressive Disorder (342) Depressed mood (62)
2 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
282
Tried for
Major Depressive Disorder (252) Anxious mood (58)
1 more
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Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
272
Tried for
Anxious mood (258) Insomnia (21)
4 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
189
Tried for
Insomnia (177) Major Depressive Disorder (23)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (220 evaluations)
Side effects
Anxious mood Irritability 126 more
How many evaluations
266
Tried for
Major Depressive Disorder (533) Depressed mood (79)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (215 evaluations)
Side effects
Nausea Weight gain 120 more
How many evaluations
303
Tried for
Major Depressive Disorder (510) Depressed mood (117)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (194 evaluations)
Side effects
Sex drive (libido) decreased Fatigue 105 more
How many evaluations
245
Tried for
Major Depressive Disorder (405) Depressed mood (131)
6 more
Check to add this treatment to your profile
Treatment name(s)
Perceived effectiveness
for Major Depressive Disorder (125 evaluations)
Side effects
Anxious mood Anxiety and frustration 25 more
How many evaluations
151
Tried for
Major Depressive Disorder (440) Depressed mood (6)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (203 evaluations)
Side effects
Dry mouth Weight gain 139 more
How many evaluations
237
Tried for
Major Depressive Disorder (384) Depressed mood (108)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (146 evaluations)
Side effects
Nausea Vivid dreams 95 more
How many evaluations
194
Tried for
Major Depressive Disorder (350) Depressed mood (111)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (160 evaluations)
Side effects
Headaches Sex drive (libido) decreased 80 more
How many evaluations
195
Tried for
Major Depressive Disorder (342) Depressed mood (62)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (116 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 75 more
How many evaluations
148
Tried for
Major Depressive Disorder (252) Anxious mood (58)
1 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (116 evaluations)
Side effects
Drowsiness Sleepiness 48 more
How many evaluations
141
Tried for
Anxious mood (258) Insomnia (21)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (88 evaluations)
Side effects
Grogginess Excessive daytime sleepiness (somnolence) 40 more
How many evaluations
94
Tried for
Insomnia (177) Major Depressive Disorder (23)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 457
20s 3,544
30s 5,780
40s 6,915
50s 5,809
60s 2,368
70+ 340

Sex

Distribution of sex

77% Female
23% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 5,188
20-29 years 2,001
30-39 years 1,353
40-49 years 766
50-59 years 223
60-69 years 30
70+ years 3

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 13,654
Not Diagnosed 2,090

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: