Major Depressive Disorder

We’re all in this for good.

By sharing your stories and data, you will:
  • help each other live better and uncover the best ways to manage your health today
  • help researchers shorten the path to new treatments tomorrow

How much good can your data do? A whole lot, as co-founder Jamie Heywood explains in this video.

What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
572
Tried for
Major Depressive Disorder (530) Depressed mood (82)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
525
Tried for
Major Depressive Disorder (475) Depressed mood (111)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
501
Tried for
Major Depressive Disorder (416) Depressed mood (180)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
438
Tried for
Major Depressive Disorder (386) Depressed mood (131)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
417
Tried for
Major Depressive Disorder (413) Depressed mood (8)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
394
Tried for
Major Depressive Disorder (332) Depressed mood (132)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
308
Tried for
Major Depressive Disorder (292) Depressed mood (56)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
295
Tried for
Major Depressive Disorder (265) Anxious mood (62)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
256
Tried for
Anxious mood (248) Insomnia (15)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
202
Tried for
Insomnia (192) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (248 evaluations)
Side effects
Anxious mood Irritability 134 more
How many evaluations
306
Tried for
Major Depressive Disorder (530) Depressed mood (82)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (226 evaluations)
Side effects
Nausea Dry mouth 113 more
How many evaluations
316
Tried for
Major Depressive Disorder (475) Depressed mood (111)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (221 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 126 more
How many evaluations
298
Tried for
Major Depressive Disorder (415) Depressed mood (180)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (221 evaluations)
Side effects
Dry mouth Weight gain 140 more
How many evaluations
279
Tried for
Major Depressive Disorder (386) Depressed mood (131)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for Major Depressive Disorder (158 evaluations)
Side effects
Anxious mood Depressed mood 40 more
How many evaluations
195
Tried for
Major Depressive Disorder (413) Depressed mood (8)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (156 evaluations)
Side effects
Nausea Weight gain 96 more
How many evaluations
206
Tried for
Major Depressive Disorder (332) Depressed mood (132)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (159 evaluations)
Side effects
Loss of sex drive (libido) Headaches 89 more
How many evaluations
190
Tried for
Major Depressive Disorder (292) Depressed mood (56)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (136 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 80 more
How many evaluations
172
Tried for
Major Depressive Disorder (265) Anxious mood (62)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (128 evaluations)
Side effects
Drowsiness Sleepiness 36 more
How many evaluations
148
Tried for
Anxious mood (248) Insomnia (15)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (91 evaluations)
Side effects
Grogginess Drowsiness 40 more
How many evaluations
98
Tried for
Insomnia (192) Major Depressive Disorder (22)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 359
20s 3,544
30s 6,268
40s 7,671
50s 6,818
60s 2,982
70+ 459

Sex

Distribution of sex

75% Female
25% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 5,449
20-29 years 2,086
30-39 years 1,413
40-49 years 813
50-59 years 243
60-69 years 32
70+ years 4

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 14,194
Not Diagnosed 2,124

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: