Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
790
Tried for
Major Depressive Disorder (748) Depressed mood (89)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
694
Tried for
Major Depressive Disorder (643) Depressed mood (125)
8 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
619
Tried for
Major Depressive Disorder (511) Depressed mood (220)
7 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
557
Tried for
Major Depressive Disorder (489) Depressed mood (165)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
551
Tried for
Major Depressive Disorder (547) Anxious mood (9)
5 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
498
Tried for
Major Depressive Disorder (420) Depressed mood (167)
3 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
381
Tried for
Major Depressive Disorder (362) Depressed mood (62)
2 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
380
Tried for
Major Depressive Disorder (346) Anxious mood (72)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
296
Tried for
Anxious mood (291) Insomnia (12)
3 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
221
Tried for
Insomnia (211) Major Depressive Disorder (23)
4 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (395 evaluations)
Side effects
Anxious mood Headaches 166 more
Total evaluations
455
Tried for
Major Depressive Disorder (748) Depressed mood (89)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (346 evaluations)
Side effects
Dry mouth Weight gain 145 more
Total evaluations
451
Tried for
Major Depressive Disorder (642) Depressed mood (124)
8 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (288 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 157 more
Total evaluations
391
Tried for
Major Depressive Disorder (511) Depressed mood (220)
7 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (296 evaluations)
Side effects
Dry mouth Nausea 157 more
Total evaluations
367
Tried for
Major Depressive Disorder (489) Depressed mood (165)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for Major Depressive Disorder (249 evaluations)
Side effects
Anxious mood Depressed mood 63 more
Total evaluations
302
Tried for
Major Depressive Disorder (546) Anxious mood (9)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (229 evaluations)
Side effects
Suicidal thoughts or urges Weight gain 124 more
Total evaluations
294
Tried for
Major Depressive Disorder (421) Depressed mood (167)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (205 evaluations)
Side effects
Dry mouth Sleepiness 95 more
Total evaluations
239
Tried for
Major Depressive Disorder (362) Depressed mood (62)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (196 evaluations)
Side effects
Weight gain Sex drive (libido) decreased 95 more
Total evaluations
235
Tried for
Major Depressive Disorder (346) Anxious mood (72)
2 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (164 evaluations)
Side effects
Drowsiness Sleepiness 42 more
Total evaluations
181
Tried for
Anxious mood (291) Insomnia (12)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (107 evaluations)
Side effects
Dry mouth Grogginess 46 more
Total evaluations
115
Tried for
Insomnia (211) Major Depressive Disorder (23)
4 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 529
20s 4,184
30s 7,656
40s 10,446
50s 10,167
60s 4,741
70+ 733
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 6,588
20-29 years 2,566
30-39 years 1,765
40-49 years 1,060
50-59 years 340
60-69 years 58
70+ years 6

Sex

Distribution of sex

77% Female
23% Male

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 16,496
Not Diagnosed 2,244

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: