Major Depressive Disorder

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What is Major Depressive Disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with Major Depressive Disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, insomnia, fatigue, and pain) regardless of condition.
Last updated:

Treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Type
How many have tried
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
544
Tried for
Major Depressive Disorder (496) Depressed mood (114)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
519
Tried for
Major Depressive Disorder (480) Depressed mood (74)
6 more
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Treatment name(s)
Type
Psychotherapy
How many have tried
447
Tried for
Major Depressive Disorder (443) Depressed mood (9)
4 more
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Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
413
Tried for
Major Depressive Disorder (389) Depressed mood (72)
6 more
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Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
395
Tried for
Major Depressive Disorder (372) Depressed mood (65)
3 more
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Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
395
Tried for
Major Depressive Disorder (374) Depressed mood (76)
3 more
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Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
370
Tried for
Major Depressive Disorder (348) Depressed mood (67)
5 more
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Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
274
Tried for
Major Depressive Disorder (245) Depressed mood (49)
3 more
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Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
222
Tried for
Anxious mood (204) Insomnia (21)
4 more
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Treatment name(s)

(Desyrel)
Type
Prescription Drug
How many have tried
160
Tried for
Insomnia (144) Major Depressive Disorder (25)
5 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

Compare treatments taken by people with Major Depressive Disorder

You’ve tried
Treatment name(s)
Perceived effectiveness
Side effects
How many evaluations
Tried for
Check to add this treatment to your profile
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for Major Depressive Disorder (193 evaluations)
Side effects
Nausea Weight gain 127 more
How many evaluations
290
Tried for
Major Depressive Disorder (496) Depressed mood (114)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for Major Depressive Disorder (205 evaluations)
Side effects
Anxious mood Nausea 115 more
How many evaluations
259
Tried for
Major Depressive Disorder (480) Depressed mood (74)
6 more
Check to add this treatment to your profile
Treatment name(s)
Perceived effectiveness
for Major Depressive Disorder (109 evaluations)
Side effects
Anxious mood Anger 17 more
How many evaluations
137
Tried for
Major Depressive Disorder (443) Depressed mood (9)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Zoloft)
Perceived effectiveness
for Major Depressive Disorder (178 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 112 more
How many evaluations
217
Tried for
Major Depressive Disorder (389) Depressed mood (72)
6 more
Check to add this treatment to your profile
Treatment name(s)

(Celexa)
Perceived effectiveness
for Major Depressive Disorder (166 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 78 more
How many evaluations
201
Tried for
Major Depressive Disorder (372) Depressed mood (65)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for Major Depressive Disorder (158 evaluations)
Side effects
Dry mouth Weight gain 112 more
How many evaluations
190
Tried for
Major Depressive Disorder (374) Depressed mood (76)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Prozac)
Perceived effectiveness
for Major Depressive Disorder (143 evaluations)
Side effects
Nausea Anxious mood 92 more
How many evaluations
186
Tried for
Major Depressive Disorder (348) Depressed mood (67)
5 more
Check to add this treatment to your profile
Treatment name(s)

(Lexapro)
Perceived effectiveness
for Major Depressive Disorder (111 evaluations)
Side effects
Sex drive (libido) decreased Weight gain 73 more
How many evaluations
144
Tried for
Major Depressive Disorder (245) Depressed mood (49)
3 more
Check to add this treatment to your profile
Treatment name(s)

(Klonopin)
Perceived effectiveness
for Anxious mood (104 evaluations)
Side effects
Drowsiness Sleepiness 40 more
How many evaluations
126
Tried for
Anxious mood (204) Insomnia (21)
4 more
Check to add this treatment to your profile
Treatment name(s)

(Desyrel)
Perceived effectiveness
for Insomnia (69 evaluations)
Side effects
Excessive daytime sleepiness (somnolence) Dizziness 40 more
How many evaluations
77
Tried for
Insomnia (144) Major Depressive Disorder (25)
5 more

Data from patients with Major Depressive Disorder, who reported starting treatments within the last 5 years.
Last updated:
You’ve tried this treatment.

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Who has Major Depressive Disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 228
20s 2,486
30s 3,707
40s 4,272
50s 3,601
60s 1,434
70+ 199

Sex

Distribution of sex

76% Female
24% Male
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 4,011
20-29 years 1,593
30-39 years 1,077
40-49 years 590
50-59 years 189
60-69 years 20
70+ years 2

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 11,395
Not Diagnosed 1,967

These charts show data from Major Depressive Disorder patients who have completed their condition history
Last updated: