Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
735
Tried for
major depressive disorder (689) depressed mood (89)
6 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
530
Tried for
major depressive disorder (497) depressed mood (82)
6 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
475
Tried for
major depressive disorder (470) anxious mood (8)
6 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
468
Tried for
major depressive disorder (404) depressed mood (139)
6 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
439
Tried for
major depressive disorder (384) depressed mood (123)
4 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
376
Tried for
major depressive disorder (329) depressed mood (110)
3 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
362
Tried for
major depressive disorder (321) anxious mood (86)
2 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
224
Tried for
major depressive disorder (202) depressed mood (36)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
180
Tried for
anxious mood (177) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
157
Tried for
depressed mood (129) major depressive disorder (33)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (368 evaluations)
Side effects
anxious mood dry mouth 151 more
Total evaluations
436
Tried for
major depressive disorder (689) depressed mood (89)
6 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (283 evaluations)
Side effects
dry mouth weight gain 136 more
Total evaluations
345
Tried for
major depressive disorder (497) depressed mood (82)
6 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (253 evaluations)
Side effects
anxious mood flashbacks 51 more
Total evaluations
301
Tried for
major depressive disorder (470) anxious mood (8)
6 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (264 evaluations)
Side effects
decreased sex drive (libido) weight gain 138 more
Total evaluations
320
Tried for
major depressive disorder (404) depressed mood (139)
6 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (243 evaluations)
Side effects
nausea dry mouth 130 more
Total evaluations
296
Tried for
major depressive disorder (384) depressed mood (123)
4 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (202 evaluations)
Side effects
nausea decreased sex drive (libido) 98 more
Total evaluations
241
Tried for
major depressive disorder (329) depressed mood (110)
3 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (177 evaluations)
Side effects
decreased sex drive (libido) weight gain 101 more
Total evaluations
211
Tried for
major depressive disorder (321) anxious mood (86)
2 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (113 evaluations)
Side effects
nausea dry mouth 60 more
Total evaluations
133
Tried for
major depressive disorder (202) depressed mood (36)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (93 evaluations)
Side effects
drowsiness tiredness 22 more
Total evaluations
99
Tried for
anxious mood (177) major depressive disorder (3)
3 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (83 evaluations)
Side effects
weight gain drowsiness 52 more
Total evaluations
118
Tried for
depressed mood (129) major depressive disorder (33)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
Last updated:

Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 341
20s 4410
30s 9569
40s 14363
50s 16721
60s 10240
70+ 2272
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 8803
20-29 years 3719
30-39 years 2716
40-49 years 1745
50-59 years 608
60-69 years 114
70+ years 19

Distribution of sex

Sex
Sex Proportion # of patients
Male 11995
Female 46225

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 23845
Not Diagnosed 2334

These charts show data from MDD patients who have completed their condition history
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