Major depressive disorder

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What is major depressive disorder?

Major depressive disorder, also known as clinical depression, is marked by depressed mood, inactivity, lack of interest, insomnia, feelings of worthlessness, diminished ability to think, and may include thoughts of suicide.

Common symptoms reported by people with major depressive disorder

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
Last updated:

Treatments taken by people with major depressive disorder

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Wellbutrin XL)
Type
Prescription Drug
How many have tried
887
Tried for
major depressive disorder (842) depressed mood (100)
6 more
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
696
Tried for
major depressive disorder (649) depressed mood (137)
3 more
Treatment name(s)

(Zoloft)
Type
Prescription Drug
How many have tried
643
Tried for
major depressive disorder (539) depressed mood (228)
5 more
Treatment name(s)

(Talk therapy)
Type
Psychotherapy
How many have tried
612
Tried for
major depressive disorder (606) anxious mood (10)
4 more
Treatment name(s)

(Effexor XR)
Type
Prescription Drug
How many have tried
596
Tried for
major depressive disorder (524) depressed mood (182)
5 more
Treatment name(s)

(Prozac)
Type
Prescription Drug
How many have tried
548
Tried for
major depressive disorder (465) depressed mood (185)
4 more
Treatment name(s)

(Lexapro)
Type
Prescription Drug
How many have tried
439
Tried for
major depressive disorder (395) anxious mood (83)
1 more
Treatment name(s)

(Celexa)
Type
Prescription Drug
How many have tried
357
Tried for
major depressive disorder (338) depressed mood (55)
2 more
Treatment name(s)

(Klonopin)
Type
Prescription Drug
How many have tried
282
Tried for
anxious mood (279) major depressive disorder (6)
2 more
Treatment name(s)

(Abilify)
Type
Prescription Drug
How many have tried
180
Tried for
depressed mood (146) major depressive disorder (39)
3 more

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
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Compare treatments taken by people with major depressive disorder

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Wellbutrin XL)
Perceived effectiveness
for major depressive disorder (437 evaluations)
Side effects
anxious mood headaches 173 more
Total evaluations
500
Tried for
major depressive disorder (842) depressed mood (100)
6 more
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for major depressive disorder (353 evaluations)
Side effects
dry mouth weight gain 166 more
Total evaluations
467
Tried for
major depressive disorder (649) depressed mood (137)
3 more
Treatment name(s)

(Zoloft)
Perceived effectiveness
for major depressive disorder (307 evaluations)
Side effects
decreased sex drive (libido) weight gain 164 more
Total evaluations
405
Tried for
major depressive disorder (539) depressed mood (228)
5 more
Treatment name(s)

(Talk therapy)
Perceived effectiveness
for major depressive disorder (307 evaluations)
Side effects
anxious mood depressed mood 66 more
Total evaluations
369
Tried for
major depressive disorder (606) anxious mood (10)
4 more
Treatment name(s)

(Effexor XR)
Perceived effectiveness
for major depressive disorder (330 evaluations)
Side effects
dry mouth weight gain 156 more
Total evaluations
406
Tried for
major depressive disorder (524) depressed mood (182)
5 more
Treatment name(s)

(Prozac)
Perceived effectiveness
for major depressive disorder (251 evaluations)
Side effects
weight gain nausea 117 more
Total evaluations
326
Tried for
major depressive disorder (465) depressed mood (185)
4 more
Treatment name(s)

(Lexapro)
Perceived effectiveness
for major depressive disorder (231 evaluations)
Side effects
weight gain decreased sex drive (libido) 95 more
Total evaluations
276
Tried for
major depressive disorder (395) anxious mood (83)
1 more
Treatment name(s)

(Celexa)
Perceived effectiveness
for major depressive disorder (201 evaluations)
Side effects
sleepiness dry mouth 96 more
Total evaluations
231
Tried for
major depressive disorder (338) depressed mood (55)
2 more
Treatment name(s)

(Klonopin)
Perceived effectiveness
for anxious mood (161 evaluations)
Side effects
drowsiness sleepiness 41 more
Total evaluations
171
Tried for
anxious mood (279) major depressive disorder (6)
2 more
Treatment name(s)

(Abilify)
Perceived effectiveness
for depressed mood (89 evaluations)
Side effects
weight gain nausea 72 more
Total evaluations
134
Tried for
depressed mood (146) major depressive disorder (39)
3 more
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with major depressive disorder, who reported starting treatments within the last 5 years.
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Who has major depressive disorder on PatientsLikeMe?


Age
Age Proportion # of patients
<20 561
20s 4,846
30s 9,379
40s 13,474
50s 13,617
60s 6,636
70+ 1,116
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 7,933
20-29 years 3,359
30-39 years 2,396
40-49 years 1,507
50-59 years 511
60-69 years 99
70+ years 12

Sex

Distribution of sex

79% Female
21% Male

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 19,949
Not Diagnosed 2,430

These charts show data from MDD patients who have completed their condition history
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