Systemic Mast Cell Disorder (SMCD)

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What is Systemic Mast Cell Disorder (SMCD)?

Systemic mast cell disorder is the presence of too many mast (mastocytes) cells in the body. Mast cells are a part of the body's immune system and help to regulate allergic reactions. SMCD causes musculoskeletal pain, abdominal discomfort, nausea, vomiting, ulcers, diarrhea, and skin lesions.

Common symptoms reported by people with Systemic Mast Cell Disorder (SMCD)

Common symptoms
How bad it is
What people are taking for it

Reports may be affected by other conditions and/or medication side effects. We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition.
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Treatments taken by people with Systemic Mast Cell Disorder (SMCD)

Treatment name(s)
Type
How many have tried
Tried for
Treatment name(s)

(Cromolyn ophthalmic)
Type
Prescription Drug
How many have tried
9
Treatment name(s)

(Flexeril)
Type
Prescription Drug
How many have tried
3
Tried for
pain (3)
Treatment name(s)

(Voltaren Gel)
Type
Prescription Drug
How many have tried
2
Tried for
pain (2)
Treatment name(s)

(Cymbalta)
Type
Prescription Drug
How many have tried
2
Tried for
depressed mood (2) pain (1)
Treatment name(s)

(Naprosyn)
Type
Prescription Drug
How many have tried
2
Tried for
pain (2)
Treatment name(s)

(Ultram)
Type
Prescription Drug
How many have tried
2
Tried for
pain (2)
Treatment name(s)

(Excedrin Migraine)
Type
Over the Counter Drug
How many have tried
1
Tried for
pain (1)
Treatment name(s)

(Chinese acupuncture and aravedic herbs)
Type
Procedures
How many have tried
1
Tried for
pain (1)
Treatment name(s)

(Xanax)
Type
Prescription Drug
How many have tried
1
Tried for
anxious mood (1)
Treatment name(s)

(Essential Oils)
Type
Other
How many have tried
1
Tried for
anxious mood (1) depressed mood (1)

Data from patients with Systemic Mast Cell Disorder (SMCD), who reported starting treatments within the last 5 years.
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Compare treatments taken by people with Systemic Mast Cell Disorder (SMCD)

Treatment name(s)
Perceived effectiveness
Side effects
Total evaluations
Tried for
Treatment name(s)

(Cromolyn ophthalmic)
Perceived effectiveness
for Systemic Mast Cell Disorder (SMCD) (4 evaluations)
Side effects
diarrhea flatulence 3 more
Total evaluations
5
Treatment name(s)

(Flexeril)
Perceived effectiveness
No evaluations
Side effects
No evaluations
Total evaluations
0
Tried for
pain (3)
Treatment name(s)

(Voltaren Gel)
Perceived effectiveness
for pain (1 evaluation)
Side effects
upset stomach
Total evaluations
1
Tried for
pain (2)
Treatment name(s)

(Cymbalta)
Perceived effectiveness
for depressed mood (1 evaluation)
Side effects
anxious mood dizziness 2 more
Total evaluations
1
Tried for
depressed mood (2) pain (1)
Treatment name(s)

(Naprosyn)
Perceived effectiveness
for pain (2 evaluations)
Side effects
heart palpitations
Total evaluations
2
Tried for
pain (2)
Treatment name(s)

(Ultram)
Perceived effectiveness
No evaluations
Side effects
No evaluations
Total evaluations
0
Tried for
pain (2)
Treatment name(s)

(Excedrin Migraine)
Perceived effectiveness
No evaluations
Side effects
No evaluations
Total evaluations
0
Tried for
pain (1)
Treatment name(s)

(Chinese acupuncture and aravedic herbs)
Perceived effectiveness
No evaluations
Side effects
No evaluations
Total evaluations
0
Tried for
pain (1)
Treatment name(s)

(Xanax)
Perceived effectiveness
No evaluations
Side effects
No evaluations
Total evaluations
0
Tried for
anxious mood (1)
Treatment name(s)

(Essential Oils)
Perceived effectiveness
No evaluations
Side effects
No evaluations
Total evaluations
0
Tried for
anxious mood (1) depressed mood (1)
  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
  • Severe
  • Moderate
  • Mild
  • None

Data from patients with Systemic Mast Cell Disorder (SMCD), who reported starting treatments within the last 5 years.
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Who has Systemic Mast Cell Disorder (SMCD) on PatientsLikeMe?


Age
Age Proportion # of patients
<20 2
20s 9
30s 12
40s 19
50s 19
60s 8
70+ 4
Age at first symptom
Age at first symptom Proportion # of patients
0-19 years 14
20-29 years 8
30-39 years 8
40-49 years 6
50-59 years 2
60-69 years 0
70+ years 0

Distribution of sex

Sex
Sex Proportion # of patients
Male 15
Female 60

Diagnosis status
Diagnosis status Proportion # of patients
Diagnosed 34
Not Diagnosed 11

These charts show data from Systemic Mast Cell Disorder (SMCD) patients who have completed their condition history
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