Studies of Elevated Parathyroid Activity

Conditions Phase Intervention Type


Ages Eligible for Study
Genders Eligible for Study


Hypoglycemia, Genetics, and Hyperparathyroidism


National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Inclusion Criteria

Patients (male or female any age) with known or suspected primary hyperparathyroidism or a
related disorder (such as familial multiple endocrine neoplasia type 1 [MEN1]) will be

The vast majority of patients will be greater than age 18.

In the rare occasion where special resources might be appropriate (uremic patient, young
child), the availability of special resources would be confirmed prior to admission.

Exclusion Criteria

There are no absolute exclusions.

Detailed Description

Patients whose parathyroid activity is elevated above normal are referred to as having hyperparathyroidism. This study will help researchers better understand the causes of hyperthyroidism and to evaluate and improve methods for diagnosis and treatment. In this study, patients diagnosed with or suspected of having hyperparathyroidism will be selected to participate. In addition, patients with related conditions such as parathyroid tumors, will also be selected. Subjects will be asked to provide blood and urine for testing to confirm their condition. They will then be surgically treated by removal of the parathyroid gland(s) (parathyroidectomy). Subjects with parathyroid tumors will undergo several diagnostic tests to determine the exact location of the tumor as well as the tumor's activity. The tests may include; ultrasounds, nuclear scanning, CT scans, MRI, and specialized blood testing. Sometimes parathyroidectomy leads to hypoparathyroidism. Options for treating the patients after the surgical procedure will also be addressed. Calcium and Vitamin D supplements are typically the mainstay of post parathyroidectomy therapy. Other potential treatments include transplanting the parathyroid gland(s) to other areas of the body....

Contacts and Locations

Please refer to this study by its identifier: NCT00001277

Overall Contact Backup

William F Simonds, M.D.
(301) 496-9299


  • National Institutes of Health Clinical Center, 9000 Rockville Pike
    Bethesda, Maryland United States

    Status: Recruiting

    Contact info For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)