Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Volunteers

Conditions Phase Intervention Type
N/A

Eligibility

Ages Eligible for Study
3 years and up
Genders Eligible for Study
Both

Keywords

Cognitive, Genetics, Development, Klinefelter Syndrome, Jacob Syndrome, Trisomy X, Healthy Volunteer, XXY, XXXY, XXXXY, XYY, XXYY, XO, XXXX, XXX, XXXXX, Triple X, Congenital Adrenal Hyperplasia, and Twin

Sponsors

NIH
National Institute of Mental Health (NIMH)

Inclusion Criteria

FOR PARTICIPANTS WITH AUTISM SPECTRUM DISORDERS:

Meeting DSM-IV criteria for one of the pervasive developmental disorders (i.e., autistic
disorder, Asperger disorder, or pervasive developmental disorder-not otherwise specified).

Having a minimum IQ of 70.

Exclusion Criteria

FOR ADHD PARTICIPANTS:

A full-scale IQ of less than 80.

Birth before 34 weeks of gestation.

Other axis I psychiatric disorder requiring treatment with medication at study entry (with
the exception of oppositional-defiant disorder).

Detailed Description

Magnetic Resonance Imaging (MRI) unlike X-rays and CT-scans does not use radiation to create a picture. MRI use as the name implies, magnetism to create pictures with excellent anatomical resolution. Functional MRIs are diagnostic tests that allow doctors to not only view anatomy, but physiology and function. It is for these reasons that MRIs are excellent methods for studying the brain. In this study, researchers will use MRI to assess brain anatomy and function in X and Y chromosome variation, healthy volunteers, and patients with a variety of childhood onset psychiatric disorders. The disorders include attention deficit disorder, autism, congenital adrenal hyperplasia, childhood-onset schizophrenia, dyslexia, obsessive compulsive disorder, Sydenham's chorea, and Tourette's syndrome. Results of the MRIs showing the anatomy of the brain and brain function will be compared across age, sex (gender), and diagnostic groups. Correlations between brain and behavioral measures will be examined for normal and clinical populations.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00001246

Overall Contact Backup

Jonathan Blumenthal
(301) 435-4516

Locations

  • National Institutes of Health Clinical Center, 9000 Rockville Pike
    Bethesda, Maryland United States

    Status: Recruiting

    Contact info For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL)
    800-411-1222xTTY8664111010