- Ages Eligible for Study
- 24 months to 100 years
- Genders Eligible for Study
Urologic Malignant Disorders, Birt Hogg Dube, Von Hippel Lindau, and Hereditary Papillary Renal Cancer/Renal Cell Acarcinoma
- National Cancer Institute (NCI)
- Subject Category C:
Category C will include relatives and spouses who enroll in this study primarily for
genetic linkage studies. These individuals will contribute a blood sample for DNA analysis
only. No imaging diagnostic testing will be performed on individuals from this category.
Persons unable to give informed consent.
We will investigate the clinical manifestations and molecular genetic defects of heritable urologic malignant disorders. Families with urologic malignancy with known or suspected genetic basis will be enrolled. Affected individuals or individuals suspected of having a germline urologic malignant disorder will undergo periodic clinical assessment and genetic analyses for the purpose of: 1) definition and characterization of phenotype, 2) determination of the natural history of the disorder, and 3) genotype/phenotype correlation. Genetic linkage studies may be performed in situations in which the genetic basis of the disorder has not been elucidated.
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00001238