Lipoprotein Metabolism in Normal Volunteers and Patients With High Levels of Lipoproteins

Conditions Phase Intervention Type
N/A

Eligibility

Ages Eligible for Study
18 years and up
Genders Eligible for Study
Both

Keywords

Cholesterol, Apolipoproteins, and Kinetics

Sponsors

NIH
National Heart, Lung, and Blood Institute (NHLBI)

Inclusion Criteria

Subjects with new and undefined dyslipidemia-particularly familial disorders with extreme
phenotypes.

Healthy normal volunteers - (18 years old or older) controls to investigate the formation
of HDL for prebeta HDL.

Euthyroid.

Exclusion Criteria

Healthy control volunteers are initially screened for secondary causes of hyperlipidemia
and are excluded if they have any clinically significant laboratory abnormality (i.e.,
liver disease, disease, kidney disease, endocrine disease,), chronic medical problems
(i.e., hypertension, migraines, inflammatory bowel, hepatitis, HIV) or require any chronic
medications (i.e., acne, asthma).

The healthy control volunteers weight must fall within the current guidelines for ideal
body weight.

Pregnant women.

Unwilling to follow metabolic diet.

Allergic to iodine.

Unable to sign consent form.

Detailed Description

Researchers plan to study the fat-rich particles, called lipoproteins, which circulate in the blood. This study is designed to improve understanding of normal, as well as abnormal, lipoprotein metabolism and the role it plays in the development of hardening of the arteries (atherosclerosis). Patients participating in this study will receive injections of lipoproteins or apolipoproteins (the protein component of lipoproteins) that have been isolated and purified. These lipoproteins will be labeled with small amounts of radioactive material and sterilized before they are injected into the patient. Patients participating in the study will be required to have blood samples taken, and provide urine samples throughout the course of the study. In addition, patient will be required to follow a specially formulated diet. Patients will be weighed throughout the course of the study.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00001154

Overall Contact Backup

Robert D Shamburek, M.D.
(301) 496-3460

Locations

  • National Institutes of Health Clinical Center, 9000 Rockville Pike
    Bethesda, Maryland United States

    Status: Recruiting

    Contact info For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL)
    800-411-1222xTTY8664111010