Orphenadrine Treatment Report

Category: Prescription Drugs

Most Popular Types: Norflex, Orphenadrine ER, Disipal (Show all)

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See also: Orphenadrine-aspirin-caffeine

What is Orphenadrine?

An example of Orphenadrine

Orphenadrine is an anti-Parkinson's and skeletal muscle relaxant. It is used in the treatment of muscle spasm and tremors associated with musculoskeletal conditions.

Reported Purpose & Perceived Effectiveness

Reasons and Perceived effectiveness
Perceived Effectiveness
Purpose # of patients # of patients with evaluations
Major
Moderate
Slight
None
Can’t tell
15 3 Efficacy_major Efficacy_slight Efficacy_cant_tell
14 2 Efficacy_moderate
10 3 Efficacy_major Efficacy_slight Efficacy_cant_tell
3 0
2 1 Efficacy_moderate
1 0

See all 51 patients currently taking Orphenadrine

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Reported Side Effects

Side effects as an overall problem

Severe
1
Moderate
2
Mild
4
None
7

Reported Dosages

  100mg as needed 200 as needed 50 mg daily 60 mg daily 90 mg daily 100 mg daily 150 mg daily 200 mg daily 300 mg daily
  8 Number of Patients: 8 1 Number of Patients: 1 1 Number of Patients: 1 1 Number of Patients: 1 1 Number of Patients: 1 14 Number of Patients: 14 3 Number of Patients: 3 21 Number of Patients: 21 2 Number of Patients: 2  

Reported Stop Reasons

Why Patients Stopped Taking Orphenadrine (multiple reasons could be selected)
Reason # Patients Percentage of patients
Doctor's advice 7   Doctor's advice: 50%
Side effects too severe 3   Side effects too severe: 21%
Did not seem to work 3   Did not seem to work: 21%
Other 2   Other: 14%
Personal research 2   Personal research: 14%
Change in health plan coverage 1   Change in health plan coverage: 7%
Course of treatment ended 1   Course of treatment ended: 7%

See all 14 patients who’ve stopped taking Orphenadrine

Currently Taking Orphenadrine

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more
0

Stopped Taking Orphenadrine

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more
0

Reported Adherence, Burden & Cost See details from patient evaluations

Adherence

Taking treatment as prescribed

Adherence of Orphenadrine

Always
7 50%
Usually
4 29%
Sometimes
2 14%
Never
1 7%

Burden

Difficulty being on treatment

Burden of Orphenadrine

Very
0 0%
Somewhat
0 0%
A little
3 21%
Not at all
11 79%

Cost

Paid out of pocket

Cost of Orphenadrine

$200+
0 0%
$100-199
0 0%
$50-99
0 0%
$25-49
0 0%
< $25
8 100%

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4 patient evaluations for Orphenadrine

Purpose: Stiffness/Spasticity (Started Nov 04, 2007)
Date Dosage Perceived effectiveness Side Effects Adherence Burden
Jul 06, 2011   ?Can't tell NoneNoneNoneNoneNone NeverNeverNeverNeverNever Not at allNot at allNot at allNot at allNot at all
May 24, 2011   Led_efficacy_4Led_efficacy_4Led_efficacy_4Led_efficacy_4Major ModerateModerateModerateModerateModerate AlwaysAlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at allNot at all
May 12, 2011 300 mg Daily Led_efficacy_4Led_efficacy_4Led_efficacy_4Led_efficacy_4Major SevereSevereSevereSevereSevere AlwaysAlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at allNot at all
Apr 30, 2011 300 mg Daily Led_efficacy_4Led_efficacy_4Led_efficacy_4Led_efficacy_4Major ModerateModerateModerateModerateModerate UsuallyUsuallyUsuallyUsuallyUsually Not at allNot at allNot at allNot at allNot at all
May 25, 2010 300 mg Daily Led_efficacy_4Led_efficacy_4Led_efficacy_4Led_efficacy_4Major ModerateModerateModerateModerateModerate UsuallyUsuallyUsuallyUsuallyUsually SomewhatSomewhatSomewhatSomewhatSomewhat
Jun 09, 2009 300 mg Daily Led_efficacy_4Led_efficacy_4Led_efficacy_4Led_efficacy_4Major ModerateModerateModerateModerateModerate AlwaysAlwaysAlwaysAlwaysAlways A littleA littleA littleA littleA little
Side effects:
Memory problems, Loss of short term memory, Forgetting Words
Date
Jul 06, 2011
Advice & Tips
Affects short-term memory /retention
Cost
< $25 monthly
Date
May 24, 2011
Advice & Tips
Unfortunately after many years relatively free of stiffness, tremor & associated pain over the last 18 months I became increasingly forgetful & confused.
Cost
< $25 monthly
Date
May 12, 2011
Advice & Tips
For many years (4+) this helped reduce tremor & associated pain, helped balance & was generally beneficial BUT the cognitive side effects, similar to dementia, were intolerable.
Cost
< $25 monthly
Date
Apr 30, 2011
Advice & Tips
I HAVE FOUND NO PROBLEMS MANAGING IT. HOWEVER A SIDE EFFECT OF WHICH I WAS UNAWARE HAS BEEN INCREASING MEMORY PROBLEMS & SOME CONFUSION. I AM CURRENTLY PHASING OUT THE DRUG & AS I'M STILL ON AGONISTS (REQUIP) I'M CONCERNED THAT I WILL START DOPAMINS
Cost
< $25 monthly
Date
May 25, 2010
Advice & Tips
WITH MY CONSULTANT & PD NURSE I AM REDUCING THE DOSE OVER TIME AS THE SIDE-EFFECTS HAVE BECOME DISTRESSING - MAINLY CONFUSION & LOSS OF SHORT-TERM MEMORY
Cost
< $25 monthly
  • Icon_thumb_off 0 helpful marks
  • tigger13039
    Sex: M
    Data Quality: 3 stars
    MS: 17 yrs
    Type: Primary Progressive
    Sensation: Severe
    Overall: Moderate
    Cognition: severe
    Vision: moderate
    Speech: moderate
    Swallowing: moderate
    Upper limb: moderate
    Walking: moderate
  • 27298-thumb
  • See tigger13039's full Orphenadrine history
Purpose: MS (Multiple Sclerosis) (Started Dec 31, 2010)
Date Dosage Perceived effectiveness Side Effects Adherence Burden
Feb 08, 2011 As needed Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_defaultModerate MildMildMildMildMild UsuallyUsuallyUsuallyUsuallyUsually A littleA littleA littleA littleA little
  • Icon_thumb_off 0 helpful marks
Purpose: Muscle spasms (Started Mar 10, 2010)
Date Dosage Perceived effectiveness Side Effects Adherence Burden
May 17, 2010 100 mg Daily Led_efficacy_2Led_efficacy_2Led_defaultLed_defaultSlight MildMildMildMildMild UsuallyUsuallyUsuallyUsuallyUsually A littleA littleA littleA littleA little
  • Icon_thumb_off 0 helpful marks
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What is orphenadrine?

Orphenadrine is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain.

Orphenadrine is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.

Orphenadrine may also be used for other purposes not listed in this medication guide.


Precautions

Do not take this medication if you are allergic to orphenadrine, or if you have:

  • problems with urination;
  • enlarged prostate;
  • glaucoma;
  • a blockage in your stomach or intestines;
  • trouble swallowing; or
  • myasthenia gravis.

Before taking orphenadrine, tell your doctor if you are allergic to any drugs, or if you have:

  • heart disease;
  • a heart rhythm disorder; or
  • coronary artery disease.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take orphenadrine.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether orphenadrine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Orphenadrine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid drinking alcohol, which can increase some of the side effects of orphenadrine.

Cold or allergy medicine, narcotic pain medicine, sleeping pills, and medicine for seizures, depression or anxiety can add to sleepiness caused by orphenadrine. Tell your doctor if you regularly use any of these medicines, or any other muscle relaxer.

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Instructions

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of orphenadrine can be fatal.

Overdose symptoms may include blurred vision, fast heart rate, confusion, weak or shallow breathing, cold or clammy skin, feeling like you might pass out, or seizure (convulsions).

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

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Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using orphenadrine and call your doctor at once if you have any of these serious side effects:

  • fast, pounding, or uneven heartbeats;
  • confusion, anxiety, agitation, tremors, hallucinations;
  • seizure (convulsions); or
  • urinating less than usual or not at all.

Less serious side effects may include:

  • dry mouth or throat;
  • blurred vision, dilated pupils;
  • headache;
  • drowsiness, dizziness;
  • nausea, vomiting, constipation; or
  • weakness.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

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Interactions

Before taking orphenadrine, tell your doctor if you are taking any of the following medicines:

  • atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);
  • bronchodilators such as ipratroprium (Atrovent) or tiotropium (Spiriva);
  • glycopyrrolate (Robinul);
  • mepenzolate (Cantil);
  • bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare); or
  • irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), or propantheline (Pro-Banthine).

This list is not complete and there may be other drugs that can interact with orphenadrine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Other Names

Antiflex, Banflex, Flexoject, Flexon, Mio-Rel, Myolin, Norflex, Norflex Injectable, Orphenate, orphenadrine, and Orfro

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Disclaimer

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04

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