You should not use this medication if you are allergic to pamidronate or to other bisphosphonates such as alendronate (Fosamax), etidronate (Didronel), ibandronate (Boniva), risedronate (Actonel), tiludronate (Skelid), or zoledronic acid (Reclast, Zometa).
Before using pamidronate, tell your doctor if you have kidney disease, a history of thyroid surgery, or if you are also taking thalidomide to treat bone marrow cancer.
Do not use pamidronate without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.
Some people using medicines similar to pamidronate have developed bone loss in the jaw, also called osteonecrosis of the jaw. Call your doctor if you have symptoms such as jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums.
Pamidronate can be harmful to the kidneys, and these effects are increased when pamidronate is used together with other medicines that can harm the kidneys. Before taking pamidronate, tell your doctor about all other medications you use. Many drugs (including some over-the-counter medicines) can be harmful to the kidneys.
Serious side effects of pamidronate include fever, severe bone pain, severe joint or muscle pain, urinating less than usual or not at all, swelling, rapid weight gain, eye pain, vision changes, confusion, uneven heart rate, extreme thirst, muscle weakness or limp feeling, and fainting or seizure.