Naltrexone Treatment Report

Category: Prescription Drugs

Most Popular Types: Low Dose Naltrexone (LDN), ReVia

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See also: Hydrocodone-Acetaminophen-Naltrexone SR Capsule

What is Naltrexone?

An example of Naltrexone

Naltrexone, in low doses such as 3mg to 4.5mg, has been found to boost the immune system in MS, autoimmune diseases, and central nervous system disorders. Naltrexone was FDA-approved in 1985 for the management of alcohol dependence and opioid dependence at 50mg doses.

Reported Purpose & Perceived Effectiveness

Reasons and Perceived effectiveness
Perceived Effectiveness
Purpose # of patients # of patients with evaluations
Major
Moderate
Slight
None
Can’t tell
418 181 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
93 58 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
87 47 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
37 20 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
32 15 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
24 16 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell

See all 701 patients currently taking Naltrexone

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Reported Side Effects

Side effects as an overall problem

Severe
23
Moderate
31
Mild
68
None
240

Commonly reported side effects, conditions, and hospitalizations associated with Naltrexone

20
11
9
8
7
6
See all 102 reported side effects See top 6 reported side effects

Reported Dosages

Frequently reported dosages based on patients currently taking Naltrexone. See all 57 dosages

  1 mg daily 1.5 mg daily 2 mg daily 2.5 mg daily 3 mg daily 3.5 mg daily 4 mg daily 4.5 mg daily 5 mg daily 50 mg daily
  24 Number of Patients: 24 34 Number of Patients: 34 10 Number of Patients: 10 8 Number of Patients: 8 169 Number of Patients: 169 25 Number of Patients: 25 39 Number of Patients: 39 328 Number of Patients: 328 9 Number of Patients: 9 18 Number of Patients: 18  

Reported Stop Reasons

Why Patients Stopped Taking Naltrexone (multiple reasons could be selected)
Reason # Patients Percentage of patients
Did not seem to work 104   Did not seem to work: 51%
Other 54   Other: 26%
Side effects too severe 46   Side effects too severe: 23%
Doctor's advice 31   Doctor's advice: 15%
Expense 8   Expense: 4%
Personal research 7   Personal research: 3%
Course of treatment ended 6   Course of treatment ended: 3%
Not indicated 5   Not indicated: 2%
Change in health plan coverage 1   Change in health plan coverage: 0%

See all 200 patients who’ve stopped taking Naltrexone

Currently Taking Naltrexone

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Stopped Taking Naltrexone

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Reported Adherence, Burden & Cost See details from patient evaluations

Adherence

Taking treatment as prescribed

Adherence of Naltrexone

Always
312 86%
Usually
39 11%
Sometimes
5 1%
Never
6 2%

Burden

Difficulty being on treatment

Burden of Naltrexone

Very
6 2%
Somewhat
17 5%
A little
35 10%
Not at all
304 84%

Cost

Paid out of pocket

Cost of Naltrexone

$200+
0 0%
$100-199
1 0%
$50-99
41 13%
$25-49
167 51%
< $25
116 36%

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71 patient evaluations for Naltrexone

  • CURLYWINGS
    Sex: M
    Data Quality: 3 stars
    MS: 10 yrs
    Type: Primary Progressive
    Sensation: None
    Overall: None
    Cognition: none
    Vision: none
    Speech: none
    Swallowing: none
    Upper limb: moderate
    Walking: moderate
  • Portrait_default_thumb
  • See CURLYWINGS's full Naltrexone history
Purpose: MS (Multiple Sclerosis) (Started Jun 01, 2013)
Date Dosage Perceived effectiveness Side Effects Adherence Burden
Jun 01, 2013 4.4 mg Daily Led_efficacy_4Led_efficacy_4Led_efficacy_4Led_efficacy_4Major NoneNoneNoneNoneNone AlwaysAlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at allNot at all
Date
Jun 01, 2013
Advice & Tips
I take it in liquid form. Pill form is also available. My speech has improved. No more slurring or mumbling. Bladder has shown significant improvement. Bowel has shown improvement. Stamina is much better. This drug works for me and makes the other drugs work better. Not an approved MS drug by my doctor or the hospital (Mellon Center)
Cost
< $25 monthly
  • Icon_thumb_off 0 helpful marks
Purpose: ALS (Amyotrophic Lateral Sclerosis) (Started Feb 10, 2010)
Date Dosage Perceived effectiveness Side Effects Adherence Burden
Apr 22, 2013 4.5 mg Daily Led_efficacy_4Led_efficacy_4Led_efficacy_4Led_efficacy_4Major NoneNoneNoneNoneNone AlwaysAlwaysAlwaysAlwaysAlways A littleA littleA littleA littleA little
Mar 26, 2012 4.5 mg Daily Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_defaultModerate NoneNoneNoneNoneNone AlwaysAlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at allNot at all
Dec 14, 2011 4.5 mg Daily Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_defaultModerate MildMildMildMildMild AlwaysAlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at allNot at all
Date
Apr 22, 2013
Advice & Tips
9 months after being dx with ALS, I noticed that my voice in 2009 stabilized. In 2013, my voice and swallowing are basically the same. I give most credit to taking LDN.
Cost
$25-49 monthly
Date
Mar 26, 2012
Advice & Tips
I am seeing many ALS patients loosing their voice. I am convinced that LDN is what prevented me from loosing mine. I started on the drug a couple years ago, noticed an immediate impact, and have not gotten off. My voice is still around which was contrary to my original progression. I still struggle, but most people can understand what I am saying with very little repeating. Please consider using just to see if it works for you.
Cost
< $25 monthly
Date
Dec 14, 2011
Advice & Tips
This seemed to be the reason why I was able to keep my voice. No proof of this fact, but it certainly is the appearance from my perspective.
Cost
< $25 monthly
  • Icon_thumb_on 1 helpful mark
  • slowrambler
    Sex: M
    Data Quality: 1 star
    MS: 37 yrs
    Type: Secondary Progressive
    Relapse: Moderate
    Sensation: Severe
    Overall: Mild
    Cognition: none
    Vision: none
    Speech: none
    Swallowing: none
    Upper limb: none
    Walking: severe
  • Portrait_default_thumb
  • See slowrambler's full Naltrexone history
Purpose: MS (Multiple Sclerosis) (Started Sep 01, 2008)
Date Dosage Perceived effectiveness Side Effects Adherence Burden
Sep 07, 2012 4.5 mg Daily Led_efficacy_4Led_efficacy_4Led_efficacy_4Led_efficacy_4Major NoneNoneNoneNoneNone AlwaysAlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at allNot at all
Feb 09, 2009 4.5 mg Daily Led_efficacy_4Led_efficacy_4Led_efficacy_4Led_efficacy_4Major NoneNoneNoneNoneNone AlwaysAlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at allNot at all
Sep 07, 2008 4.5 mg Daily Led_efficacy_4Led_efficacy_4Led_efficacy_4Led_efficacy_4Major NoneNoneNoneNoneNone AlwaysAlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at allNot at all
Date
Sep 07, 2012
Advice & Tips
This medication's given me some very un-expected increase in heat tolerance.
Cost
$50-99 monthly
Date
Sep 07, 2008
Advice & Tips
This medication is FDA approved for MS in "compounded" form only. If an MS patient can obtain a prescription for this medication (many neurologists won't consider writing a script for this), they'll need to have access to a "compounding" pharmacy. As with all medications, success rates appear to vary. Many people who I know that are using LDN have realized dramatic, if not astonishing symptomatic relief in addition to less disease activity. Some that I know tried it for a period of time without any noticible relief or change & thus stopped using it. Success rates have seemed to depend on dosage level, at least from my observations. Some using LDN notice change almost immediately at the lower dosage levels. Others, as noted above, realize no change at any dosage level. Personally, the symptom relief that I've noticed most is an increase in heat tolerance. As far as my overall success rate, I'd say this medication has done very well in slowing the progression. I've gone over 15 months without having an exacerbation or needing IV solu-medrol. 11 of those months have been since I began using LDN, & I'm not using highest dosage. Maintaining my mobility level & being essentially symptom free for this period of time is very unusual (& quite pleasant!) for me; especially over the last 3 yrs. Note: neurologists/MS specialists might recommend a dormant period of time between stopping a current medication (Beta-Seron, Avonex, etc.) & the beginning of LDN use.
Cost
$50-99 monthly
  • Icon_thumb_on 3 helpful marks
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What is naltrexone?

Naltrexone oral is an special narcotic drug that blocks the effects of other narcotic medicines and alcohol.

Naltrexone oral is used to treat narcotic drug or alcohol addiction..

Naltrexone oral may also be used for other purposes not listed in this medication guide.


Precautions

Do not take this medicine if you are allergic to naltrexone, or if you have:

  • an addiction to narcotics;
  • a history of alcohol or narcotic drug use within the past 7-10 days; or
  • drug or alcohol withdrawal symptoms.

Before taking naltrexone, tell your doctor if you are allergic to any drugs, or if you have:

  • kidney disease;
  • liver disease; or
  • a bleeding disorder such as hemophilia (if you are using naltrexone oral injection).

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether naltrexone oral passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Naltrexone oral can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Do not use narcotic drugs or alcohol while taking naltrexone oral. Never try to overcome the effects of the medication by taking large doses of narcotic drugs or alcohol. Doing so could result in dangerous effects, including coma and death. Ask your doctor before using any prescription or over-the-counter medicine to treat a cold, cough, diarrhea, or pain while taking naltrexone oral. These medicines may contain narcotics or alcohol.

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Instructions

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, stomach pain, dizziness, or seizure (convulsions).

Take the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not take extra medicine to make up the missed dose.

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Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using naltrexone oral and call your doctor at once if you have any of these serious side effects:

  • blurred vision or eye problems;
  • fast heartbeat;
  • mood changes, hallucinations (seeing or hearing things), confusion, thoughts of hurting yourself;
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • ear pain, ringing in your ears;
  • skin rash or itching; or
  • wheezing, difficulty breathing.

Less serious side effects may include:

  • feeling anxious, nervous, restless, or irritable;
  • feeling light-headed, fainting;
  • increased thirst;
  • muscle or joint aches;
  • weakness or tiredness;
  • sleep problems (insomnia); or
  • decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

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Interactions

The pain-relieving effects of any narcotic pain medications you use will be blocked if you use them during your treatment with naltrexone oral. Harmful side effects could also occur.

Before using naltrexone, tell your doctor if you use any of the following drugs:

  • buprenorphine (Buprenex, Subutex);
  • butorphanol (Stadol);
  • codeine (Tylenol with codeine);
  • hydrocodone (Lortab, Vicodin);
  • dezocine (Dalgan);
  • hydromorphone (Dilaudid);
  • levorphanol (Levo-Dromoran);
  • meperidine (Demerol);
  • methadone (Dolophine, Methadose);
  • morphine (Kadian, MS Contin, Roxanol);
  • nalbuphine (Nubain);
  • nalmefene (Revex);
  • naloxone (Narcan);
  • oxycodone (OxyContin, Roxicodone, Percocet);
  • oxymorphone (Numorphan); or
  • propoxyphene (Darvon, Darvocet).

This list it not complete and there may be other drugs that can interact with naltrexone oral. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Other Names

ReVia, Vivitrol, and naltrexone

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Disclaimer

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04

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