What is megestrol?
Megestrol is a man-made chemical similar to the female hormone progesterone.
Megestrol is used to treat loss of appetite and weight loss because of disease. Megestrol is also used in the treatment of advanced breast cancer and endometrial cancer.
Megestrol may also be used for purposes other than those listed in this medication guide.
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Precautions
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Instructions
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Side Effects
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Interactions
Precautions
Before taking megestrol, tell your doctor if you have
- diabetes or
- a history of blood clots.
You may not be able to take megestrol, or you may require a lower dose or special monitoring during treatment if you have either of the conditions listed above.
Do not take this medication if you are pregnant or are planning a pregnancy. Megestrol is in the FDA pregnancy category X. This means that megestrol is known to cause birth defects. Megestrol may cause abnormal development of the sexual organs.
Megestrol may pass into breast milk and harm a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.
There are no restrictions on food, beverages, or activity during treatment with megestrol unless your doctor directs otherwise.
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Instructions
A megestrol overdose is unlikely to threaten life. Call an emergency room or poison control center for advice.
Symptoms of a megestrol overdose are not known.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose, as directed. Do not take a double dose of this medication unless otherwise directed by your doctor.
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Side Effects
Stop taking megestrol and seek emergency medical attention or call your doctor immediately if you experience any of the following serious side effects:
- an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
- sudden severe headache;
- changes in vision; or
- numbness or swelling in an arm or leg.
Other, less serious side effects may be more likely to occur. Notify your doctor if you experience
- nausea or vomiting,
- dizziness,
- mild shortness of breath;
- weakness,
- headache,
- menstrual bleeding,
- hot flashes or sweating,
- decreased sex drive, or
- insomnia.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
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Interactions
Before taking megestrol, tell your doctor if you are taking insulin or an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glynase), chlorpropamide (Diabinese), tolazamide (Tolinase), or tolbutamide (Orinase). Megestrol may decrease the effects of these medications, and your blood sugar level may increase. If you have diabetes, monitor your blood sugar and talk to your doctor if you notice any unusual changes.
Drugs other than those listed here may also interact with megestrol. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.
Other Names
Megace, Megace ES, and megestrol
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Disclaimer
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04
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