Tizanidine is a short-acting medication that should be taken only for daily activities that require relief from muscle spasticity.
Do not take tizanidine if you are also taking the antidepressant fluvoxamine (Luvox), or the antibiotic ciprofloxacin (Cipro).
Do not use tizanidine at a time when muscle tone is needed to assure safe balance and movement for certain activities. In some situations, it may endanger your physical safety to be in a state of reduced muscle tone.
Switching between tizanidine tablets and capsules, or changing the way you take it with regard to eating, can cause an increase in side effects or a decrease in therapeutic effect. Follow your doctor’s instructions carefully. After making any changes in how you take tizanidine, contact your doctor if you notice any change in how well the medicine works or if it causes increased side effects.
Do not take more than three doses (36 mg) of tizanidine in a 24-hour period. Too much of this medication can damage your liver.
Cold or allergy medicine, narcotic pain medicine, sleeping pills, other muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by tizanidine. Tell your doctor if you need to use any of these other medicines together with tizanidine.
Avoid drinking alcohol. It can increase some of the side effects of tizanidine.