What is ALS Phase 3 Study Dexpramipexole (KNS-760704)?

Category: Others

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See also: Clinical Trial

NCT01281189 is a randomized, double-blind, placebo-controlled, multi-center study of the safety and efficacy of dexpramipexole in subjects with amyotrophic lateral sclerosis (ALS). Dexpramipexole was previously known as KNS-760704. Other study IDs: EMPOWER, 223AS302, EUDRA CT NO:2010-022818-19.

Reported purpose & perceived effectiveness
Purpose Patients Patients with evaluations Perceived Effectiveness
ALS (Amyotrophic Lateral Sclerosis) 38 31
Participate in clinical trial 17 12
Increase effect of another treatment 2 0

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell

Side effects

Side effects as an overall problem

side_effects of ALS Phase 3 Study Dexpramipexole (KNS-760704)"

Severe
1
Moderate
2
Mild
9
None
25

Dosages

Most common dosages (by patients currently using ALS Phase 3 Study Dexpramipexole (KNS-760704))
Dosage Patients
2 mg daily 1
2 intl units daily 1
2 daily 7
2 other daily 3
30 mg daily 1
150 mg daily 1
300 mg daily 17
Why Patients Stopped Using ALS Phase 3 Study Dexpramipexole (KNS-760704) (multiple reasons could be selected)
Reason Patients
Course of treatment ended 12
Other 10
Did not seem to work 4
Side effects too severe 3
Doctor's advice 2
Personal research 1
See all 24 patients who’ve stopped using ALS Phase 3 Study Dexpramipexole (KNS-760704)

Duration

Currently Using ALS Phase 3 Study Dexpramipexole (KNS-760704)
Duration Patients
0-1 month 0
1-3 months 0
3-6 months 0
6 months-1 year 0
1-2 years 0
2 years or more 7
Stopped Using ALS Phase 3 Study Dexpramipexole (KNS-760704)
Duration Patients
0-1 month 1
1-3 months 0
3-6 months 0
6 months-1 year 3
1-2 years 19
2 years or more 1
Adherence
Always
35 95%
Usually
2 5%
Sometimes
0 0%
Never
0 0%
Burden
Very
0 0%
Somewhat
0 0%
A little
7 19%
Not at all
30 81%
Cost
$200+
0 0%
$100-199
1 3%
$50-99
1 3%
$25-49
0 0%
< $25
27 93%
Last updated:

6 patient evaluations for ALS Phase 3 Study Dexpramipexole (KNS-760704)

jaws-als
35884-thumb
jaws-als
Sex: M
Data Quality: 3 stars
Bulbar: severe
Arms: severe
Chest: severe
Legs: severe
I am: vg
I have:
ALS

See jaws-als's full ALS Phase 3 Study Dexpramipexole (KNS-760704) history

Mar 26, 2012 (Started Jul 05, 2011)

  • Perceived effectiveness for ALS (Amyotrophic Lateral Sclerosis): Can’t tell
  • Side Effects: None
  • Adherence: Always
  • Burden: Not at all
Dosage: 300 mg Daily
Cost: < $25 monthly

Jul 20, 2011 (Started Jul 05, 2011)

  • Perceived effectiveness for ALS (Amyotrophic Lateral Sclerosis): Can’t tell
  • Side Effects: None
  • Adherence: Always
  • Burden: Not at all
Dosage: 300 mg Daily
Cost: < $25 monthly

  • 5 helpful marks
Spodfather
35867-thumb
Spodfather
Sex: M
Data Quality: 1 star
Bulbar: mild
Arms: severe
Chest: mild
Legs: moderate
I am: n
I have:
ALS

See Spodfather's full ALS Phase 3 Study Dexpramipexole (KNS-760704) history

Sep 7, 2011 (Started Jun 14, 2011)

  • Perceived effectiveness for ALS (Amyotrophic Lateral Sclerosis): None
  • Side Effects: Mild
  • Adherence: Always
  • Burden: Not at all
Dosage: 2 Daily
Advice & Tips: Struggling to believe this is doing anything for me in terms of slowing progression, if anything its as though its sped up! maybe i'm on the dummy drug.
Cost: < $25 monthly
Side effects: Sleep problems

Aug 23, 2011 (Started Jun 14, 2011)

  • Perceived effectiveness for ALS (Amyotrophic Lateral Sclerosis): Can’t tell
  • Side Effects: Mild
  • Adherence: Always
  • Burden: Not at all
Dosage: 2 Daily
Cost: < $25 monthly
Side effects: Sleep problems

Aug 9, 2011 (Started Jun 14, 2011)

  • Perceived effectiveness for ALS (Amyotrophic Lateral Sclerosis): Can’t tell
  • Side Effects: Mild
  • Adherence: Always
  • Burden: Not at all
Dosage: 2 Daily
Advice & Tips: This may be a result of Dex or may not but since the i started 2 months ago my breath test improved from 86 to 93! either way it gave me a lift.
Cost: < $25 monthly
Side effects: Sleep problems

Jun 14, 2011 (Started Jun 14, 2011)

  • Perceived effectiveness for ALS (Amyotrophic Lateral Sclerosis): Can’t tell
  • Side Effects: Mild
  • Adherence: Always
  • Burden: Not at all
Dosage: 2 Daily
Advice & Tips: The only side effects i have noticed is a change in my sleeping and slightly more indegestion
Cost: < $25 monthly
Side effects: Sleep problems

  • 4 helpful marks
jadedjohn
37652-thumb
jadedjohn
Sex: M
Data Quality: 1 star
Bulbar: mild
Arms: moderate
Chest: none
Legs: moderate
I am: vb
I have:
ALS

See jadedjohn's full ALS Phase 3 Study Dexpramipexole (KNS-760704) history

Jan 31, 2012 (Started Sep 09, 2011)

  • Perceived effectiveness for Participate in clinical trial: None
  • Side Effects: None
  • Adherence: Always
  • Burden: A little
Dosage: 300 mg Daily
Cost: $100-199 monthly

  • 1 helpful mark
Last updated:
Showing 3 of 6 patient evaluations for ALS Phase 3 Study Dexpramipexole (KNS-760704)