The combination of lamivudine and zidovudine (Combivir) should not be taken together with any other medications that contain either of these two drugs. This includes Epivir, Retrovir, Epzicom (abacavir and lamivudine), and Trizivir (abacavir, lamivudine, zidovudine).
Before taking lamivudine and zidovudine, tell your doctor if you have kidney disease, liver disease, a pancreas disorder, bone marrow suppression, or problems with your muscles.
Lamivudine and zidovudine can lower the blood cells in your body that help you fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. It is important that you not miss any scheduled visits to your doctor.
If you have hepatitis B you may develop liver symptoms after you stop taking lamivudine and zidovudine, even months after stopping. Your doctor may want to check your liver function on a regular basis for several months after you stop using this medication. Do not miss any scheduled visits.
Some people have developed a life-threatening condition called lactic acidosis while taking lamivudine and zidovudine. Early signs of lactic acidosis generally get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms of lactic acidosis, such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired.