What is enoxaparin?
Enoxaparin is a blood thinner, also called anticoagulant (an-tye-koe-AG-yoo-lant). Enoxaparin prevents the formation of blood clots.
Enoxaparin is used to prevent blood clots that are sometimes called deep vein thrombosis (DVT), which can lead to blood clots in the lungs. A DVT can occur after certain types of surgery, or in people who are bed-ridden due to a prolonged illness. DVT sometimes occurs suddenly for other reasons.
Enoxaparin is also used to prevent blood vessel complications in people with certain types of angina (chest pain) or heart attacks called non-Q-wave myocardial infarction or ST-segment elevation myocardial infarction.
Enoxaparin may also be used for other purposes not listed in this medication guide.
You should not receive this medication if you are allergic to enoxaparin, heparin, or pork products, or if you have:
- any type of major bleeding; or
- a very low blood platelet count.
Before receiving enoxaparin, tell your doctor if you are allergic to any drugs, or if you have:
- kidney disease;
- liver disease;
- bacterial infection of the lining of your heart;
- a bleeding or blood clotting disorder such as hemophilia;
- uncontrolled or untreated high blood pressure;
- a stomach ulcer;
- eye problems caused by diabetes;
- a history of hemorrhagic stroke;
- a history of low blood platelets caused by receiving heparin;
- if you have recently had surgery on your brain, spine, or eyes;
- if you have an artificial heart valve.
FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. If you are pregnant, tell your doctor if you have an artificial heart valve.
It is not known whether enoxaparin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
During your treatment with enoxaparin, avoid taking aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), or any type of blood thinners unless your doctor tells you to. Using these medications together with enoxaparin can increase your risk of bleeding.
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Seek emergency medical attention if you think you have received too much of this medicine.
Overdose may cause nosebleeds, blood in your urine or stools, easy bruising or bleeding, or any bleeding that won’t stop.
Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.
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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers or call your doctor at once if you have any of these serious side effects:
- bleeding that won't stop;
- pale skin, easy bruising, unusual weakness;
- swelling, bruising, or bleeding where an incision was made during a surgery or other medical procedure;
- sudden numbness or weakness, headache, confusion, problems with vision, speech, or balance;
- pain or swelling in one or both legs;
- cough, chest pain, trouble breathing; or
- slow heart rate, weak pulse, muscle weakness, tingly feeling.
Less serious side effects may include:
- nausea, diarrhea;
- swelling in your hands or feet; or
- mild swelling, pain, bruising, or redness where the medicine was injected.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
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Before you receive enoxaparin, tell your doctor about any blood thinners you have been using recently, such as warfarin (Coumadin).
The following drugs can interact with enoxaparin. Tell your doctor if you are using any of these:
- sulfinpyrazone (Anturane);
- salicylates such as Novasal, Doan's Extra Strength, Salflex, Tricosal, and others;
- aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), indomethacin (Indocin), ketorolac (Toradol), and others; or
- medication used to prevent blood clots, such as alteplase (Activase), anistreplase (Eminase), clopidogrel (Plavix), dipyridamole (Persantine), streptokinase (Kabikinase, Streptase), ticlopidine (Ticlid), and urokinase (Abbokinase).
This list is not complete and there may be other drugs that can interact with enoxaparin. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
Clexane, Clexane Forte, Lovenox, Lovenox HP, and enoxaparin
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