What is temozolomide?
Temozolomide interferes with the development of cancer cells, slowing their growth and spread in the body.
Temozolomide is used together with radiation therapy to treat certain types of brain tumor in adults.
Temozolomide is sometimes given after other cancer medications have been tried without successful treatment of the tumor.
Temozolomide may also be used for other purposes not listed in this medication guide.
You should not this medication if you are allergic to temozolomide or to another cancer medication called dacarbazine (DTIC-Dome).
If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:
- liver disease; or
- kidney disease.
FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use temozolomide without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.
It is not known whether temozolomide passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Taking temozolomide may increase your risk of developing certain types of bone marrow cancer. Talk with your doctor about your individual risk.
Women and older adults may be more likely to have bone marrow suppression (a weakened immune system) while taking temozolomide. This can lead to an increased risk of infection or illness.
Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.
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Seek emergency medical attention if you think you have used too much of this medicine. Taking temozolomide for more than 5 days in a row can cause life-threatening overdose.
Overdose symptoms may include fever, pale skin, increased thirst, dry skin, easy bruising or bleeding, confusion, weakness, and urinating less than usual or not at all.
Contact your doctor if you miss a dose or forget to take your temozolomide.
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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- seizure (convulsions);
- numbness or tingling on one side of your body;
- signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, unusual weakness;
- dry cough, feeling short of breath, weight loss, night sweats;
- pain or burning when you urinate; or
- white patches or sores inside your mouth or on your lips.
Less serious side effects may include:
- hair loss;
- tired feeling;
- diarrhea, constipation;
- mild skin rash;
- dizziness, blurred vision;
- sleep problems (insomnia); or
- unusual or unpleasant taste in your mouth.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Before taking temozolomide, tell your doctor if you are using any of the following drugs:
- carbamazepine (Carbatrol, Tegretol);
- divalproex sodium (Depakote);
- phenytoin (Dilantin);
- valproic acid (Depakene, Depacon);
- steroids (prednisone and others); or
- a sulfa drug such as Bactrim, Septra, Cotrim, or SMX-TMP.
This list is not complete and there may be other drugs that can interact with temozolomide. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Temodar and temozolomide
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Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04