What is Clonazepam?

An example of Clonazepam

Clonazepam, a benzodiazepine, is used alone or as an adjunct in the treatment of seizure disorders and for panic disorders. Off label it is used for restless leg syndrome, neuralgia, multifocal tic disorder, parkinsonian dysarthria, bipolar disorder and as an adjunct in treatment of schizophrenia.

Reported Purpose & Perceived Effectiveness

Reasons and Perceived effectiveness
Perceived Effectiveness
Purpose # of patients # of patients with evaluations
Major
Moderate
Slight
None
Can’t tell
1,409 405 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
392 75 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
373 120 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
320 78 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
246 81 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell
194 46 Efficacy_major Efficacy_moderate Efficacy_slight Efficacy_none Efficacy_cant_tell

See all 3,489 patients currently taking Clonazepam

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Reported Side Effects

Side effects as an overall problem

Severe
70
Moderate
164
Mild
324
None
425

Commonly reported side effects, conditions, and hospitalizations associated with Clonazepam

133
74
54
38
35
25
See all 196 reported side effects See top 6 reported side effects

Reported Dosages

Frequently reported dosages based on patients currently taking Clonazepam. See all 122 dosages

  0.5mg as needed 1mg as needed 0.125 mg daily 0.25 mg daily 0.5 mg daily 1 mg daily 1.5 mg daily 2 mg daily 3 mg daily 4 mg daily
  297 Number of Patients: 297 159 Number of Patients: 159 70 Number of Patients: 70 113 Number of Patients: 113 608 Number of Patients: 608 860 Number of Patients: 860 207 Number of Patients: 207 482 Number of Patients: 482 198 Number of Patients: 198 141 Number of Patients: 141  

Reported Stop Reasons

Why Patients Stopped Taking Clonazepam (multiple reasons could be selected)
Reason # Patients Percentage of patients
Doctor's advice 204   Doctor's advice: 32%
Did not seem to work 185   Did not seem to work: 29%
Other 152   Other: 23%
Side effects too severe 139   Side effects too severe: 21%
Course of treatment ended 67   Course of treatment ended: 10%
Personal research 31   Personal research: 5%
Expense 21   Expense: 3%
Not indicated 16   Not indicated: 2%
Change in health plan coverage 14   Change in health plan coverage: 2%

See all 617 patients who’ve stopped taking Clonazepam

Currently Taking Clonazepam

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Stopped Taking Clonazepam

A bar graph

0-1 month 1-3 months 3-6 months 6 months-1year 1-2 years 2 years or more

Reported Adherence, Burden & Cost See details from patient evaluations

Adherence

Taking treatment as prescribed

Adherence of Clonazepam

Always
670 68%
Usually
199 20%
Sometimes
94 10%
Never
20 2%

Burden

Difficulty being on treatment

Burden of Clonazepam

Very
31 3%
Somewhat
64 7%
A little
149 15%
Not at all
739 75%

Cost

Paid out of pocket

Cost of Clonazepam

$200+
3 0%
$100-199
3 0%
$50-99
13 2%
$25-49
64 10%
< $25
585 88%

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186 patient evaluations for Clonazepam

  • rose5
    Sex: F
    Data Quality: 3 stars
    Parkinson's: 12 yrs
    Hoehn-Yahr 4 Type: Parkinson's disease On
    Mouth/throat: mild
    Arms: moderate
    Chest: mild
    Legs: mild
  • 13543-thumb
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Purposes: Dystonia and Parkinson's Disease (Started Apr 18, 2005)
Date Dosage Dystonia Perceived effectiveness Parkinson's Disease Perceived effectiveness Side Effects Adherence Burden
Sep 15, 2012 4 mg Daily Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_defaultModerate Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_defaultModerate NoneNoneNoneNoneNone AlwaysAlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at allNot at all
Jul 14, 2012 4 mg Daily Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_defaultModerate Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_defaultModerate NoneNoneNoneNoneNone AlwaysAlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at allNot at all
Sep 04, 2010 4 mg Daily Led_efficacy_4Led_efficacy_4Led_efficacy_4Led_efficacy_4Major Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_defaultModerate NoneNoneNoneNoneNone AlwaysAlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at allNot at all
Dec 13, 2009 4 mg Daily Led_efficacy_4Led_efficacy_4Led_efficacy_4Led_efficacy_4Major Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_defaultModerate NoneNoneNoneNoneNone AlwaysAlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at allNot at all
Date
Sep 15, 2012
Advice & Tips
I have severe dystonia in my legs and feet. I take my meds as soon as I wake up because I cannot get up and walk for about 1/2 an hour.
Cost
< $25 monthly
Date
Jul 14, 2012
Advice & Tips
NOT HELPING AS MUCH AS IN THE PAST WITH DYSTONIA
Cost
< $25 monthly
Date
Dec 13, 2009
Advice & Tips
I was prescribed Klonopin because of my dystonia which came on at the same time as my PD. I had trouble sleeping at night partially because I would get severe pain in the arch of my foot and the calf of my leg. It would wake me up in the middle of the night screaming in pain. Then my foot would turn on it's side and my toes would curl up making it impossible for me to walk. I also was having daytime problems. I would be walking somewhere and in an instant my foot would turn on it's side & my toes would crunch in. It is excruciatingly painful, and you have no control over it. I have to sit and wait for my foot to loosen up for 15-45 minutes. I have only a few episodes a month since Klonopin. Before, I couldn't even guess how many times it happened in 1 month. I take 1mg in the am, 1mg in the afternoon, and 2mg before bed. It has been a great benefit to me.
Cost
< $25 monthly
  • Icon_thumb_off 0 helpful marks
Purpose: Difficulty sleeping through night (Started Jan 01, 2009)
Date Dosage Perceived effectiveness Side Effects Adherence Burden
Sep 06, 2012 2 mg Daily Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_defaultModerate NoneNoneNoneNoneNone AlwaysAlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at allNot at all
Sep 18, 2011 2 mg Daily Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_defaultModerate NoneNoneNoneNoneNone AlwaysAlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at allNot at all
  • Icon_thumb_off 0 helpful marks
  • Alie
    Sex: F
    Data Quality: 3 stars
    Major Depressive Disorder
    Depression: 3
    Mania: 0
    Emotional: 3
    Anxiety: 2
    Compulsion: 2
    External Stress: Overwhelming
    Rx Therapy
    27 F
    Function: Low
    Distress: Moderate
  • 21825-thumb
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Purposes: Panic Disorder, Anxious mood, Muscle tension, and Panic attacks (Started Apr 01, 2006)
Date Dosage Panic Disorder Perceived effectiveness Anxious mood Perceived effectiveness Muscle tension Perceived effectiveness Panic attacks Perceived effectiveness Side Effects Adherence Burden
Sep 04, 2012 As needed Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_default Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_default Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_default Led_efficacy_2Led_efficacy_2Led_defaultLed_default MildMildMildMild UsuallyUsuallyUsuallyUsually SomewhatSomewhatSomewhatSomewhat
Jan 15, 2012 As needed Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_default Led_efficacy_4Led_efficacy_4Led_efficacy_4Led_efficacy_4 Led_efficacy_2Led_efficacy_2Led_defaultLed_default Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_default MildMildMildMild AlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at all
Apr 15, 2010 As needed Led_efficacy_4Led_efficacy_4Led_efficacy_4Led_efficacy_4 Led_efficacy_3Led_efficacy_3Led_efficacy_3Led_default Led_efficacy_4Led_efficacy_4Led_efficacy_4Led_efficacy_4 MildMildMildMild AlwaysAlwaysAlwaysAlways Not at allNot at allNot at allNot at all
Side effects:
Sleepiness
  • Icon_thumb_off 0 helpful marks
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What is clonazepam?

Clonazepam is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Clonazepam affects chemicals in the brain that may become unbalanced and cause anxiety.

Clonazepam is used to treat seizure disorders or panic disorder.

Clonazepam may also be used for other purposes not listed in this medication guide.


Precautions

Do not use this medication if you have severe liver disease, or if you are allergic to clonazepam or to other benzodiazepines, such as alprazolam (Xanax), chlordiazepoxide (Librium), clorazepate (Tranxene), lorazepam (Ativan), or oxazepam (Serax).

Before taking clonazepam, tell your doctor if you are allergic to any drugs, or if you have:

  • kidney or liver disease;
  • glaucoma;
  • asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems;
  • a history of depression or suicidal thoughts or behavior; or
  • a history of drug or alcohol addiction.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category D. Clonazepam may cause harm to an unborn baby, and may cause breathing or feeding problems in a newborn. But having a seizure during pregnancy could harm both the mother and the baby. Do not start taking clonazepam during pregnancy without telling your doctor you are pregnant.

If you become pregnant while taking clonazepam for seizures, do not stop taking clonazepam without your doctor’s advice. Seizure control is very important during pregnancy and the benefits of preventing seizures may outweigh any risks posed by taking clonazepam.

Clonazepam may pass into breast milk and could harm a nursing baby. Do not breast-feed a baby while taking this medication.

The sedative effects of clonazepam may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking clonazepam.

Clonazepam may be habit-forming and should be used only by the person it was prescribed for. Clonazepam should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

Do not drink alcohol while taking clonazepam. This medication can increase the effects of alcohol.

Clonazepam can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

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Instructions

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, and fainting.

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

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Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • confusion, hallucinations, unusual thoughts or behavior;
  • hyperactivity, agitation, hostility;
  • unusual or involuntary eye movements;
  • weak or shallow breathing;
  • depressed mood, thoughts of suicide or hurting yourself;
  • chest tightness, fast or pounding heartbeats;
  • painful or difficult urination, urinating more or less than usual;
  • pale skin, easy bruising or bleeding; or
  • new or worsening seizures.

Less serious side effects may include:

  • drowsiness, dizziness, spinning sensation;
  • memory problems;
  • tired feeling, muscle weakness, lack of balance or coordination;
  • slurred speech;
  • drooling or dry mouth, sore gums;
  • runny or stuffy nose;
  • loss of appetite, nausea, diarrhea, constipation;
  • blurred vision;
  • headache;
  • nervousness, sleep problems (insomnia);
  • skin rash; or
  • weight changes.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Interactions

Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for depression or anxiety can add to sleepiness caused by clonazepam. Tell your doctor if you regularly use any of these medicines, or any other seizure medications.

Also tell your doctor if you are using any of the following drugs:

  • propantheline (Pro-Banthine);
  • an antifungal medication such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);
  • an antidepressant such as amitriptyline (Elavil, Etrafon), doxepin (Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), and others;
  • a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton);
  • an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate); or
  • medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril).

This list is not complete and there may be other drugs that can interact with clonazepam. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Other Names

Klonopin, Klonopin Wafer, and clonazepam

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Disclaimer

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04

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