What is abacavir/lamivudine/zidovudine?
Abacavir-lamivudine-zidovudine is an antiviral medication. It is in a group of human immunodeficiency virus (HIV) medicines called reverse transcriptase inhibitors. This medication helps keep the HIV virus from reproducing in the body.
This medication is used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS). This medication is not a cure for HIV or AIDS.
This medication may also be used for other purposes not listed in this medication guide. This medication should not be given to people who weigh less than 90 pounds.
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Precautions
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Instructions
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Side Effects
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Interactions
Precautions
You should not take this medication if you have liver disease. Do not take this medicine if you have ever had an allergic reaction to abacavir. Tell your doctor if you have had an allergic reaction to any medicine that contains abacavir, such as Epzicom or Ziagen. Once you have had an allergic reaction to abacavir, you must never use it again.
You may need a blood test before you start taking this medication for the first time, or if you are restarting the medication after stopping for reasons not related to an allergic reaction.
Some people have developed a life-threatening condition called lactic acidosis while taking this medicine. You may be more likely to develop lactic acidosis if you are overweight or have liver disease, or if you have taken certain HIV or AIDS medications for a long time. Talk with your doctor about your individual risk.
If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:
- kidney disease;
- hepatitis B;
- high blood pressure or heart disease, or a risk factor for heart disease such as smoking, diabetes, or high cholesterol.
FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant. HIV can be passed to the baby if the mother is not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection while you are pregnant.
You should not breast-feed while you are using this medication. Women with HIV or AIDS should not breast-feed at all. Even if your baby is born without HIV, you may still pass the virus to the baby in your breast milk.
This medication should not be used to treat HIV in adolescents weighing less than 90 pounds.
Avoid taking other medications that contain abacavir, lamivudine, or zidovudine, such as Combivir, Epivir, Epzicom, Trizivir, or Ziagen.
Avoid having unprotected sex or sharing needles, razors, or toothbrushes. Taking this medication will not prevent you from passing HIV to other people. Talk with your doctor about safe methods of preventing HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
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Instructions
Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, headache, dizziness, drowsiness, lethargy, and confusion.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Do not allow this medicine to run out completely before you get your prescription refilled. It is important that you not stop taking the medicine once you have started. If you miss several doses, you may have a dangerous or even fatal allergic reaction once you start taking the medicine again. If you stop taking Trizivir for any reason, talk to your doctor before you start taking the medication again.
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Side Effects
Stop using this medication and call your doctor at once if you have any of these signs of an allergic reaction to abacavir:
- Group 1 - fever;
- Group 2 - rash;
- Group 3 - nausea, vomiting, diarrhea, stomach pain;
- Group 4 - general tiredness, body aches;
- Group 5 - shortness of breath, cough, sore throat.
Once you have had an allergic reaction to abacavir, you must never use it again. If you stop taking Trizivir for any reason, talk to your doctor before you start taking the medication again.
You may have other serious side effects that may not be signs of an allergic reaction. Continue using this medicine and call your doctor if you have any of these side effects:
- liver problems -- stomach pain, low fever, lost appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
- lactic acidosis - muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or uneven heart rate, dizziness, or feeling very weak or tired;
- fever, chills, body aches, flu symptoms, pale skin; or
- white patches or sores inside your mouth or on your lips.
Less serious side effects may include:
- changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and trunk);
- sleep problems or strange dreams;
- headache, depression, anxiety; or
- mild diarrhea.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
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Interactions
Before taking this medication, tell your doctor if you are using any of the following drugs:
- methadone (Methadose, Dolophine);
- ribavirin (Copegus, Rebetron, Virazole);
- interferon (Rebetron, Roferon, Intron, Alferon, Infergen, Avonex, Rebif, Betaseron, Actimune);
- sulfa drugs such as Bactrim or Septra;
- doxorubicin (Adriamycin);
- ganciclovir (Cytovene); or
- these other HIV medicines - emtricitabine (Emtriva, Truvada), zalcitabine (Hivid), stavudine (Zerit), or zidovudine (Retrovir).
This list is not complete and there may be other drugs that can interact with Trizivir. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Other Names
Trizivir and abacavir/lamivudine/zidovudine
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Disclaimer
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04
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