What is Duloxetine?
Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It is used for depression, general anxiety disorder, pain associated with diabetic neuropathy and for fibromyalgia.
Reported Side Effects
Side effects
as an overall problem
Commonly reported side effects, conditions, and hospitalizations associated with Duloxetine
|
Nausea
|
128 |
|
|
Sex drive (libido) decreased
|
116 |
|
|
Sweating increased
|
96 |
|
|
Dizziness
|
95 |
|
|
Weight gain
|
80 |
|
|
Insomnia
|
74 |
|
|
Brain cloud
|
72 |
|
|
Feel flat
|
58 |
|
|
Dry mouth (xerostomia)
|
57 |
|
|
Constipation
|
43 |
|
|
Sedation
|
41 |
|
|
Sweating excessive
|
30 |
|
|
Difficulty with orgasm
|
26 |
|
|
Fatigue
|
20 |
|
|
Mania
|
19 |
|
|
Drowsiness
|
15 |
|
|
Headaches
|
15 |
|
|
Sexual dysfunction
|
15 |
|
|
Excessive daytime sleepiness (somnolence)
|
13 |
|
|
Loss of appetite
|
12 |
|
|
Hospitalization
|
12 |
|
|
Brain zaps
|
12 |
|
|
Migraine headaches
|
11 |
|
|
Night sweats
|
11 |
|
|
Anxious mood
|
10 |
|
|
Nausea and vomiting
|
10 |
|
|
Tiredness
|
9 |
|
|
Hot flashes
|
9 |
|
|
Difficulty sleeping through night
|
8 |
|
|
Mood swings
|
8 |
|
|
Brain fog
|
8 |
|
|
Depressed mood
|
8 |
|
|
Blurry vision
|
8 |
|
|
Loss of sex drive (libido)
|
8 |
|
|
Dry throat
|
8 |
|
|
Elevated blood pressure
|
7 |
|
|
Depression with suicidal thoughts
|
7 |
|
|
Decreased appetite
|
7 |
|
|
Restless feeling in legs
|
7 |
|
|
Sleepiness
|
7 |
|
|
Suicidal thoughts or urges
|
7 |
|
|
Stomach pain
|
6 |
|
|
Stomach upset
|
6 |
|
|
Excessive dry mouth
|
6 |
|
|
Vivid dreams
|
6 |
|
|
Daytime sleepiness
|
6 |
|
|
Diarrhea
|
6 |
|
|
Frequent vertigo with nausea
|
5 |
|
|
Excessive yawning
|
5 |
|
|
Heart palpitations
|
5 |
|
|
Jittery feeling
|
4 |
|
|
Exhaustion
|
4 |
|
|
Sweating
|
4 |
|
|
Vomiting
|
4 |
|
|
Emotional numbness or flatness
|
4 |
|
|
Hyperactivity
|
4 |
|
|
Ringing in ears (tinnitus)
|
4 |
|
|
Dry eyes
|
4 |
|
|
Rashes (redness, swelling)
|
4 |
|
|
Urinary hesitancy
|
4 |
|
|
Frequent nausea
|
4 |
|
|
Serotonin syndrome
|
4 |
|
|
Ejaculation delayed
|
3 |
|
|
Withdrawal effects
|
3 |
|
|
Panic attacks
|
3 |
|
|
Suicidal
|
3 |
|
|
Nightmares
|
3 |
|
|
Weight loss
|
3 |
|
|
Difficulty urinating occasionally
|
3 |
|
|
Excessive sleeping (hypersomnia)
|
3 |
|
|
Hallucinations
|
3 |
|
|
SSRI Discontinuation (withdrawal) Syndrome
|
3 |
|
|
Increased fatigue
|
3 |
|
|
Dizziness (vertigo)
|
3 |
|
|
Muscle spasms
|
3 |
|
|
Depression with anxiety
|
3 |
|
|
Increased appetite
|
3 |
|
|
Swelling in legs, feet and ankles
|
3 |
|
|
Unrefreshing or poor sleep
|
3 |
|
|
No sexual desire
|
3 |
|
|
Pain in lower back
|
3 |
|
|
Bruising
|
3 |
|
|
Itching (pruritus)
|
3 |
|
|
Dizziness with nausea
|
3 |
|
|
Muscle twitching (fasciculations)
|
3 |
|
|
Increased insomnia
|
3 |
|
|
Increased or worsened depression
|
3 |
|
|
Heartburn
|
2 |
|
|
Feeling of disconnection
|
2 |
|
|
Bruxism (teeth grinding)
|
2 |
|
|
Shaky hands
|
2 |
|
|
Fever
|
2 |
|
|
Poor Concentration
|
2 |
|
|
Chronic constipation
|
2 |
|
|
Edema (fluid retention)
|
2 |
|
|
Heart rate increased
|
2 |
|
|
Constant tremors
|
2 |
|
|
Anxiety and frustration
|
2 |
|
|
Tachycardia (fast heart rate)
|
2 |
|
|
Agitation with irritability
|
2 |
|
|
Pain
|
2 |
|
|
Seizures (grand mal or tonic-clonic)
|
2 |
|
|
Abdominal bloating
|
2 |
|
|
Problems with focusing eyes
|
2 |
|
|
Urinary retention
|
2 |
|
|
Electric shock sensations
|
2 |
|
|
Bloating
|
2 |
|
|
Acid reflux
|
2 |
|
|
Constipation with occasional impaction
|
2 |
|
|
Antidepressant withdrawal syndrome
|
2 |
|
|
Sex drive (libido) increased
|
2 |
|
|
None
|
2 |
|
|
Shortness of breath (dyspnea)
|
2 |
|
|
Irritability
|
2 |
|
|
Feeling hot
|
2 |
|
|
Chest tightness
|
2 |
|
|
Aggression
|
2 |
|
|
Loss of balance
|
2 |
|
|
Elevated liver enzymes
|
2 |
|
|
Listlessness
|
2 |
|
|
Nervousness
|
2 |
|
|
Hypomania
|
2 |
|
|
Craving sweets sugar
|
2 |
|
|
Suicidal ideation
|
2 |
|
|
Anger
|
2 |
|
|
Joint pain
|
2 |
|
|
Deadened emotions
|
2 |
|
|
Mood changes
|
2 |
|
|
Dizziness and feeling faint
|
2 |
|
|
Tremor in hands
|
2 |
|
|
Somnolence
|
2 |
|
|
Shakiness
|
2 |
|
|
Apathy
|
2 |
|
|
Fluid retention weight gain
|
2 |
|
|
Allergic reaction
|
2 |
|
|
Loss of energy
|
2 |
|
|
Bowel irritability
|
2 |
|
|
Side effects when dose skipped
|
2 |
|
|
Anxiety attacks
|
2 |
|
|
Sensitivity to medications
|
1 |
|
|
Pressure headaches
|
1 |
|
|
Generalized itching
|
1 |
|
|
Cold sweat
|
1 |
|
|
Increased urinary frequency
|
1 |
|
|
eye sight is getting worse and not because of age.
|
1 |
|
|
Whole body shaking
|
1 |
|
|
Episodic disorientation
|
1 |
|
|
Horrifying nightmares
|
1 |
|
|
Adrenaline Rush
|
1 |
|
|
Stomach problems
|
1 |
|
|
Dark urine
|
1 |
|
|
Funny feeling in head.
|
1 |
|
|
Injection site irritation
|
1 |
|
|
Vivid Nightmares
|
1 |
|
|
Subjective tinnitus (clicking beating noise and pulsations in the ear)
|
1 |
|
|
Anorexia (appetite loss)
|
1 |
|
|
Vertigo
|
1 |
|
|
Increased anxiety
|
1 |
|
|
Swollen lips
|
1 |
|
|
Dyspepsia
|
1 |
|
|
Drowsy in a.m.
|
1 |
|
|
Wakefulness
|
1 |
|
|
Difficulty urinating (dysuria)
|
1 |
|
|
Liver pain
|
1 |
|
|
Fuzzy thinking
|
1 |
|
|
Sexual impotence
|
1 |
|
|
Eye pressure
|
1 |
|
|
Swelling of throat
|
1 |
|
|
Internal tremor
|
1 |
|
|
insomnia, agitation, & anxiety when stopping treatment
|
1 |
|
|
Bad mood
|
1 |
|
|
Electric shock in face
|
1 |
|
|
Hot and cold flashes
|
1 |
|
|
over heating, to the point of chest tighting and forced to not move
|
1 |
|
|
weight gain,swelling in spinal area ,hands and feet
|
1 |
|
|
Daytime tiredness
|
1 |
|
|
Insomnia agitation
|
1 |
|
|
Not interested in sex
|
1 |
|
|
at first very sleepy not now though
|
1 |
|
|
Dizziness with disorientation
|
1 |
|
|
not sure if it's affecting my memory and or response time or if that is medical problem
|
1 |
|
|
Don't remember
|
1 |
|
|
Breakthrough intermenstrual bleeding
|
1 |
|
|
triggered rapid cycling, suicide attempt
|
1 |
|
|
tired, nonchalant attitude.
|
1 |
|
|
some relief in pain and depression
|
1 |
|
|
Thick head
|
1 |
|
|
Uncontrollable shaking
|
1 |
|
|
Male sexual dysfunction
|
1 |
|
|
Alternating constipation and diarrhea
|
1 |
|
|
Increased thirst
|
1 |
|
|
Sick to my stomach
|
1 |
|
|
Body Tingling
|
1 |
|
|
Heavy sweating anytime, day or night
|
1 |
|
|
thick head & flat mood
|
1 |
|
|
Dizziness/walking like I'm drunk
|
1 |
|
|
disequalibrium
|
1 |
|
|
Oversleeping (too much sleep)
|
1 |
|
|
Tired legs
|
1 |
|
|
sleepy-loopy
|
1 |
|
|
legs seemed to be paralyzed for a minute
|
1 |
|
|
Stomach ache
|
1 |
|
|
Bladder pain
|
1 |
|
|
hard to control blood sugars
|
1 |
|
|
Dry tongue
|
1 |
|
|
Occasional nausea and vomiting
|
1 |
|
|
Feeling strange
|
1 |
|
|
Buzzing Sensation of Body
|
1 |
|
|
Constant vomiting
|
1 |
|
|
when you can't afford to stay on them its not as effective
|
1 |
|
|
Loss of coordination
|
1 |
|
|
stabbing and swelling pain stomach yellow bowel movements muddy pain
|
1 |
|
|
Overstimulated
|
1 |
|
|
noise in head
|
1 |
|
|
Headaches all day
|
1 |
|
|
Binge eating in evening
|
1 |
|
|
Anxiety with missed dose
|
1 |
|
|
Sleeplessness for first month
|
1 |
|
|
Tightness in throat and neck area
|
1 |
|
|
Diarrhea during titration
|
1 |
|
|
Sudden blasts of hunger
|
1 |
|
|
Occassional jittery feeling
|
1 |
|
|
Major Depressive Disorder
|
1 |
|
|
Hypertension
|
1 |
|
|
Meniere's Disease
|
1 |
|
|
Spinal Stenosis
|
1 |
|
|
Primary Insomnia
|
1 |
|
|
Chronic Hyperglycemia
|
1 |
|
|
Accidental Fall
|
1 |
|
|
spiking blood pressure
|
1 |
|
|
Generalized weakness (asthenia)
|
1 |
|
|
Tremor
|
1 |
|
|
Joints ache (whole body)
|
1 |
|
|
Weakness in legs
|
1 |
|
|
Dry mouth at night
|
1 |
|
|
Cramps in calf muscles
|
1 |
|
|
Hoarseness of voice
|
1 |
|
|
Bladder problems
|
1 |
|
|
Bowel problems
|
1 |
|
|
Spasms
|
1 |
|
|
Memory problems
|
1 |
|
|
Sjogrens syndrome
|
1 |
|
|
Numbness and Tingling with Pins and Needles
|
1 |
|
|
Vision difficulty
|
1 |
|
|
Incontinence
|
1 |
|
|
Heat intolerance
|
1 |
|
|
Memory lapses (brain blinks)
|
1 |
|
|
Cognitive Confusion
|
1 |
|
|
Tightness in hands
|
1 |
|
|
Double vision (diplopia)
|
1 |
|
|
Chills/fever
|
1 |
|
|
Rash or skin problems
|
1 |
|
|
Cough
|
1 |
|
|
Feeling of lump in throat
|
1 |
|
|
Kidney stones
|
1 |
|
|
Word fishing
|
1 |
|
|
Lose train of thought
|
1 |
|
|
Sore throat (Pharyngitis)
|
1 |
|
|
Nerve pain (neuralgia)
|
1 |
|
|
Hand twitches
|
1 |
|
|
Urinary Tract Infection UTI
|
1 |
|
|
Burning sensation in back
|
1 |
|
|
Pins and needles
|
1 |
|
|
Sneezing
|
1 |
|
|
Agitation
|
1 |
|
|
Loss of short term memory
|
1 |
|
|
Feelings of hopelessness
|
1 |
|
|
Dissociation
|
1 |
|
|
Hives (urticaria)
|
1 |
|
|
Eye Twitching
|
1 |
|
|
Tension headaches
|
1 |
|
|
Muscle fatigue
|
1 |
|
|
Self harm thoughts or urges
|
1 |
|
|
Menstrual cramps
|
1 |
|
|
Preoccupation with food
|
1 |
|
|
Neck pain
|
1 |
|
|
Urinary tract pain
|
1 |
|
|
Acne
|
1 |
|
|
Sadness
|
1 |
|
|
Confusion
|
1 |
|
|
Lightheadedness
|
1 |
|
|
Narrow (closed) angle glaucoma right eye
|
1 |
|
|
Dizziness with hypotension upon standing
|
1 |
|
|
Inability to experience pleasure (anhedonia)
|
1 |
|
|
Frustration
|
1 |
|
|
Restlessness
|
1 |
|
|
An overall crappy feeling all the time
|
1 |
|
|
Menstruation differences
|
1 |
|
|
Crying for good reason
|
1 |
|
|
Orthostatic/Postural Hypotension
|
1 |
|
|
Crawling sensations in skin
|
1 |
|
|
flat affect
|
1 |
|
|
Bipolar rapid cycling
|
1 |
|
|
Heart palpitations then feel faint
|
1 |
|
|
Cold and clammy
|
1 |
|
|
Paresthesia
|
1 |
|
|
Jumpy feeling
|
1 |
|
|
Extreme sedation
|
1 |
|
|
Increased Hunger
|
1 |
|
|
Visual hallucinations
|
1 |
|
|
Chills
|
1 |
|
|
Mood elevated or improved
|
1 |
|
|
Swelling in ankle
|
1 |
|
|
Loose stools
|
1 |
|
|
Thirst
|
1 |
|
|
Skin rash
|
1 |
|
|
Bad taste in mouth
|
1 |
|
|
Appetite change
|
1 |
|
|
Flu like symptoms
|
1 |
|
|
Compulsive scratching
|
1 |
|
|
Overeating
|
1 |
|
|
worsening of symptoms
|
1 |
|
|
Laziness
|
1 |
|
|
Sleep problems
|
1 |
|
|
Gas
|
1 |
|
|
Crying spells
|
1 |
|
|
"Lucite Encased" Head
|
1 |
|
|
Flatulence
|
1 |
|
|
Apathy to environment
|
1 |
|
|
Slowed thinking
|
1 |
|
|
Feeling worthless
|
1 |
|
|
Sporadic electric shock sensations in legs
|
1 |
|
|
Loose bowel movements
|
1 |
|
|
Dark, soft stools
|
1 |
|
|
Raised body temperature
|
1 |
|
|
Sensitivity to sudden loud noises
|
1 |
|
|
Muscle and joint pain
|
1 |
|
|
Cold intolerance
|
1 |
|
|
Spaced out
|
1 |
|
|
Inability to handle stress (bad stress reactions)
|
1 |
|
|
Overwhelming emotions
|
1 |
|
|
Itchy scalp
|
1 |
|
|
Feeling of insides shaking
|
1 |
|
|
Bleeding (hemorrhage)
|
1 |
|
|
Mental confusion
|
1 |
|
|
Spinning dizziness (vertigo)
|
1 |
|
|
Absence of menstruation (amenorrhea)
|
1 |
|
|
Withdrawal effects with missed dose
|
1 |
|
|
Parkinsonism
|
1 |
|
|
Swelling in hands
|
1 |
|
|
strange ideas
|
1 |
|
|
Body odor
|
1 |
|
|
Bruise easily
|
1 |
|
|
sometimes wake up more sleepy then when I laid down
|
1 |
|
|
dilated pupils
|
1 |
|
|
Outburst of anger
|
1 |
|
|
Urine smell abnormal
|
1 |
|
|
Tremor in right thumb
|
1 |
|
|
Diarrhea while sleeping
|
1 |
|
|
Drug dependence
|
1 |
|
|
Feeling out of it
|
1 |
|
|
Irregular menstrual periods
|
1 |
|
|
Seizure with staring episodes
|
1 |
|
|
Burning mouth syndrome
|
1 |
|
|
Feeling sick
|
1 |
|
|
muscle pain, legs, tendons, ankles, hands, wrist and lower arms
|
1 |
|
|
Anticipatory anxiety
|
1 |
|
|
Stimulant - interferes with sleep
|
1 |
|
|
Loss of sleep
|
1 |
|
|
Electric shock sensations in brain
|
1 |
|
|
Weird or strange dreams
|
1 |
|
|
Drenching sweats during flares
|
1 |
|
|
Uro-Genital Syndrome
|
1 |
|
|
Blood in stool
|
1 |
|
|
saw bugs
|
1 |
|
|
Increased urination
|
1 |
|
|
Pain worsened
|
1 |
|
|
Body Twitches
|
1 |
|
|
See all
368 reported side effects
▼
See top
6 reported side effects
▲
|
Currently Taking Duloxetine
A bar graph
Stopped Taking Duloxetine
A bar graph
Adherence
Taking treatment as prescribed
Adherence of Duloxetine
Always |
1242
|
85%
|
|
Usually |
142
|
10%
|
|
Sometimes |
16
|
1%
|
|
Never |
57
|
4%
|
|
Burden
Difficulty being on treatment
Burden of Duloxetine
Cost
Paid out of pocket
Cost of Duloxetine
$200+ |
28
|
3%
|
|
$100-199 |
82
|
8%
|
|
$50-99 |
186
|
19%
|
|
$25-49 |
294
|
29%
|
|
< $25 |
398
|
40%
|
|
See more information,
including instructions, precautions, side effects, and interactions.
