What is ondansetron?
Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.
Ondansetron is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy or radiation).
Ondansetron may also be used for other purposes not listed in this medication guide.
Do not use this medication if you are allergic to ondansetron, to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi).
Before taking ondansetron, tell your doctor if you are allergic to any drugs, or if you have:
- liver disease;
- a history of allergic reaction to any medicine; or
- a personal or family history of Long QT syndrome.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take ondansetron.
FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
Ondansetron can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Ondansetron orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).
Ondansetron can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
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Seek emergency medical attention if you think you have received too much of this medicine.
Overdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.
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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- blurred vision or temporary blindness;
- slow heart rate, trouble breathing;
- anxiety, agitation, shivering;
- feeling light-headed, fainting; or
- urinating less than usual or not at all.
Less serious side effects may include:
- diarrhea or constipation;
- weakness or tired feeling;
- dizziness or drowsiness;
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
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Before receiving ondansetron, tell your doctor if you are using any of the following drugs:
- phenytoin (Dilantin), phenobarbital (Luminal);
- carbamazepine (Carbatrol, Tegretol);
- tramadol (Ultram); or
- rifampin (Rifadin, Rimactane, Rifater).
This list is not complete and there may be other drugs that can interact with ondansetron. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Zofran, Zofran ODT, and ondansetron
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