Do not take this medication if you are allergic to donepezil.
Before taking donepezil, tell your doctor if you are allergic to any drugs, or if you have:
- a heart rhythm disorder such as "sick sinus syndrome" (slow heartbeats);
- a history of stomach ulcers;
- an enlarged prostate or urination problems;
- epilepsy or other seizure disorder; or
- asthma or chronic obstructive pulmonary disease (COPD).
If you have any of these conditions, you may need a dose adjustment or special tests to safely take donepezil.
FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether donepezil passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Donepezil can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Seek emergency medical attention if you think you have used too much of this medicine.
Overdose symptoms may include severe nausea, vomiting, drooling, sweating, blurred vision, feeling light-headed, slow heartbeat, shallow breathing, muscle weakness, fainting, or seizure (convulsions).
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using donepezil and call your doctor at once if you have any of these serious side effects:
- black, bloody, or tarry stools;
- coughing up blood or vomit that looks like blood or coffee grounds;
- painful or difficult urination;
- seizure (black-out or convulsions);
Less serious side effects may include:
- nausea, vomiting, diarrhea;
- loss of appetite;
- muscle cramps;
- tired feeling; or
- sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Before taking donepezil, tell your doctor if you are taking any of the following medicines:
- atropine (Donnatal, and others);
- carbamazepine (Tegretol);
- clidinium (Quarzan);
- dexamethasone (Decadron);
- dicyclomine (Bentyl);
- glycopyrrolate (Robinul);
- hyoscyamine (Anaspaz, Cystospaz, Levsin, and others);
- mepenzolate (Cantil);
- methantheline (Provocholine);
- methscopolamine (Pamine), scopolamine (Transderm-Scop);
- phenobarbital (Luminal, Solfoton);
- phenytoin (Dilantin);
- propantheline (Pro-Banthine);
- quinidine (Cardioquin, Quinidex, Quinaglute, others);
- rifampin (Rifadin, Rifamate, Rifater);
- a fungal antibiotic such as ketoconazole (Nizoral), fluconazole (Diflucan), or itraconazole (Sporanox); or
- aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), piroxicam (Feldene), and others.
This list is not complete and there may be other drugs that can interact with donepezil. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Aricept, Aricept ODT, and donepezil
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Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04