Ziprasidone is not for use in psychotic conditions related to dementia. Ziprasidone may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.
Do not use this medication if you are allergic to ziprasidone, or if you have:
- a personal or family history of "Long QT syndrome";
- history of recent heart attack; or
- uncontrolled or untreated heart failure.
Ziprasidone should never be taken together with any of the following drugs, or a life-threatening heart rhythm disorder could occur:
- arsenic trioxide (Trisenox);
- dolasetron (Anzemet);
- droperidol (Inapsine);
- halofantrine (Halfan);
- mefloquine (Lariam);
- levomethadyl acetate (no longer available in the U.S.);
- tacrolimus (Prograf);
- antibiotics such as gatifloxacin (Tequin), pentamidine (NebuPent, Pentam), moxifloxacin (Avelox), sparfloxacin (Zagam), telithromycin (Ketek);
- heart rhythm medicine such as dofetilide (Tikosyn), disopyramide (Norpace), quinidine (Cardioquin, Quinaglute), or sotalol (Betapace); or
- medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril).
Before taking ziprasidone, tell your doctor if you are allergic to any drugs, or if you have:
- a heart rhythm disorder;
- a history of heart attack or stroke;
- low blood levels of potassium or magnesium;
- diabetes (ziprasidone may raise your blood sugar);
- seizures or epilepsy;
- a history of suicidal thoughts;
- Parkinson's disease, Alzheimer's;
- trouble swallowing;
- liver disease; or
- kidney disease.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take ziprasidone.
Ziprasidone may cause you to have high blood sugar (hyperglycemia). Talk to your doctor if you have any signs of hyperglycemia such as increased thirst or urination, excessive hunger, or weakness. If you are diabetic, check your blood sugar levels on a regular basis while you are taking ziprasidone.
The ziprasidone orally disintegrating tablet may contain phenylalanine. Talk to your doctor before using this form of ziprasidone if you have phenylketonuria (PKU).
FDA pregnancy category C. It is not known whether ziprasidone is harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether ziprasidone passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Older adults may be more likely to have side effects from this medicine.
While you are taking ziprasidone, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking ziprasidone.
Ziprasidone can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Avoid drinking alcohol. It can increase some of the side effects of ziprasidone.
Seek emergency medical treatment if you think you have used too much of this medicine. Overdose symptoms may include drowsiness, problems with speech, dizziness, feeling light-headed, fainting, fast or pounding heartbeat, or restless muscle movements in your eyes, tongue, jaw, or neck.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using ziprasidone and call your doctor at once if you have any of these serious side effects:
- dizziness, feeling light-headed, fainting, fast or pounding heartbeat;
- fever, stiff muscles, confusion, sweating, fast or uneven heartbeats;
- tremor (uncontrolled shaking), restless muscle movements in your eyes, tongue, jaw, or neck;
- agitation, hostility, confusion;
- increased thirst or urination, weakness, extreme hunger; or
- penis erection that is painful or lasts 4 hours or longer.
Less serious side effects may include:
- mild skin rash;
- anxiety, headache, depressed mood;
- dizziness, drowsiness;
- muscle pain or twitching;
- nausea, vomiting, loss of appetite;
- runny or stuffy nose, cough, sore throat; or
- weight gain.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Before taking ziprasidone, tell your doctor if you regularly use any other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by ziprasidone.
Also tell your doctor if you are using any of the following drugs:
- a diuretic (water pill), blood pressure medicine, or heart rhythm medicine;
- carbamazepine (Carbatrol, Tegretol);
- cisapride (Propulsid);
- haloperidol (Haldol);
- narcotic pain medication;
- medicines used to treat Parkinson's Disease such as levodopa (Dopar, Larodopa, Sinemet, Atamet, others); or
- antibiotics such as azithromycin (Zithromax), clarithromycin (Biaxin), dirithromycin (Dynabac), erythromycin (E-Mycin, E.E.S., Erythrocin, Ery-Tab), ketoconazole (Nizoral), or telithromycin (Ketek).
This list is not complete and there may be other drugs that can interact with ziprasidone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Geodon and ziprasidone
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Copyright 1996-2004 Cerner Multum, Inc. Version 2.05. Revision date 8/23/04