Atovaquone

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What is the most important information I should know about atovaquone?

You should not use this medication if you are allergic to atovaquone.

Before using this medication, tell your doctor if you have liver disease, or a stomach or intestinal disorder.

Also tell your doctor if you use other medications such as rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate, Rimactane), a blood thinner such as warfarin (Coumadin), or a seizure medication such as carbamazepine (Carbatrol, Tegretol), divalproex (Depakote), phenytoin (Dilantin), or valproic acid (Depakene).

Take atovaquone with a meal for best results.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated.

Call your doctor at once if you have a serious side effect such as easy bruising or bleeding, fever, flu symptoms, white patches in your mouth or throat, worsening cough, wheezing, trouble breathing, a severe red or peeling skin rash, or jaundice (yellowing of the skin or eyes).

Warning

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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What is atovaquone?

Atovaquone is a medication that interferes with the reproduction of protozoa (single-cell organisms) that can cause disease in the body.

Atovaquone is used to treat or prevent pneumonia caused by a fungal infection called Pneumocystitis carinii (also called Pneumocystis jiroveci).

Atovaquone may also be used for other purposes not listed in this medication guide.

Precautions

You should not use this medication if you are allergic to atovaquone.

If you have certain conditions, you may need a dose adjustment or special tests to safely take this medication. Before you take atovaquone, tell your doctor if you have:

liver disease; or
a stomach or intestinal disorder.

FDA pregnancy category C. It is not known whether atovaquone is harmful to an unborn baby. Before you take atovaquone, tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether atovaquone passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Follow your doctor’s instructions about any restrictions on food, beverages, or activity while you are using this medication.

Instructions

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of an atovaquone overdose are not known.

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

easy bruising or bleeding, unusual weakness;
fever, flu symptoms;
white patches in your mouth or throat;
worsening cough;
bronchospasm (wheezing, chest tightness, trouble breathing);
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
nausea, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

mild nausea, vomiting, stomach pain or upset,
diarrhea, constipation;
headache;
weakness, dizziness;
muscle pain;
mild skin rash;
sweating; or
sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Interactions

Tell your doctor about all other medications you are using, especially:

carbamazepine (Carbatrol, Tegretol);
clozapine (Clozaril, FazaClo);
rifabutin (Mycobutin); or
rifampin (Rifadin, Rifater, Rifamate, Rimactane).

This list is not complete and there may be other drugs that can interact with atovaquone. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Disclaimer

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.